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Protein Overview: CG5220-PA

General Information:
Name(s) found: CG5220-PA / FBpp0082832 [FlyBase]
Description(s) found:
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  • gi|9910870|sp|Q9VEP1.1|RMJ1A_DROME RecName: Full=Putative ribosomal RNA methyltransferase CG5220; AltName: Full=rRNA (uridine-2'-O-)-methyltransferase [NCBI NR]
  • gi|7300216|gb|AAF55380.1| CG5220 [Drosophila melanogaster] [NCBI NR]
  • gi|25012244|gb|AAN71236.1| LD21957p [Drosophila melanogaster] [NCBI NR]
  • gi|24647580|ref|NP_650590.1| CG5220 [Drosophila melanogaster] [NCBI NR]
  • Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase 1 OS=Drosophila melanogaster GN=CG5220 PE=2 SV=1 [Swiss-Prot]
  • Putative ribosomal RNA methyltransferase CG5220 - Drosophila melanogaster (Fruit fly) [Swiss-Prot]
  • (Q9VEP1) Putative ribosomal RNA methyltransferase CG5220 (EC 2.1.1.-) (rRNA (uridine-2'-O-)-methyltransferase) [Swiss-Prot]
  • Putative ribosomal RNA methyltransferase CG5220 OS=Drosophila melanogaster GN=CG5220 PE=1 SV=1 [Swiss-Prot]
  • This gene is referred to in FlyBase by the symbol Dmel\CG5220 (CG5220, FBgn0038471). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:12866406..12867688. It has the cytological map location 89E10. Based on sequence similarity, it is predicted to have molecular function</span>: rRNA (uridine-2'-O-)-methyltransferase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: rRNA methylation. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG5220-PA translation from_gene[CG5220 CG5220 FBgn0038471] seq_release:3 mol_weight=33402 cds_boundaries:(3R:12,866,584..12,867,601[+]) aa_length:302 transcript_info:[CG5220-RA seq_release:3] gene_info:[gene symbol:CG5220 FBgn0038471 gene_boundaries:( [hmr_yeast5_DM3-1_pombe.fasta]
  • (AE003716) CG5220 gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG5220-PA [Drosophila melanogaster]gi|24647580|ref|NP_650590.1| CG5220-PA [Drosophila melanogaster]gi|25012244|gb|AAN71236.1| LD21957p [Drosophila melanogaster]gi|9910870|sp|Q9VEP1|RRM1_DROME Putative ribosomal RNA methyltransferase CG5220 (rRNA (uridi [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3R:join(12866569..12866689,12866745..12867427,12867485..12867589); ID=FBpp0082832; name=CG5220-PA; parent=FBgn0038471,FBtr0083391; dbxref=FlyBase:FBpp0082832,FlyBase_Annotation_IDs:CG5220-PA,GB_protein:AAF55380.1,REFSEQ:NP_650590,GB_prot [fly-100309-contam.fasta]
  • CG5220-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Putative ribosomal RNA methyltransferase CG5220 (rRNA (uridine-2'-O-)-methyltransferase) [nr-271106-contam.fasta]
  • LD21957p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=3R:join(12866569..12866689,12866745..12867427,12867485..12867589); ID=FBpp0082832; name=CG5220-PA; parent=FBgn0038471,FBtr0083391; dbxref=FlyBase:FBpp0082832,FlyBase_Annotation_IDs:CG5220-PA,GB_protein:AAF55380.1,REFSEQ:NP_650590,GB_protein:AAF55380; MD5=d43991b3dea165fea343e48dff6291bd; length=302; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:join(12866569..12866689,12866745..12867427,12867485..12867589); ID=FBpp0082832; name=CG5220-PA; parent=FBgn0038471,FBtr0083391; dbxref=FlyBase:FBpp0082832,FlyBase_Annotation_IDs:CG5220-PA,GB_protein:AAF55380.1,REFSEQ:NP_650590,GB_protein:AAF55380; MD5=d43991b3dea165fea343e48dff6291bd; length=302; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • type=protein; loc=3R:join(12866569..12866689,12866745..12867427,12867485..12867589); ID=FBpp0082832; name=CG5220-PA; parent=FBgn0038471,FBtr0083391; dbxref=FlyBase:FBpp0082832,FlyBase_Annotation_IDs:CG5220-PA,GB_protein:AAF55380.1,REFSEQ:NP_650590,GB_protein:AAF55380,FlyMine:FBpp0082832,modMine:FBpp0082832; MD5=d43991b3dea165fea343e48dff6291bd; length=302; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=3R:join(17040847..17040967,17041023..17041705,17041763..17041867); ID=FBpp0082832; name=CG5220-PA; parent=FBgn0038471,FBtr0083391; dbxref=FlyBase:FBpp0082832,FlyBase_Annotation_IDs:CG5220-PA,GB_protein:AAF55380.1,REFSEQ:NP_650590,GB_protein:AAF55380,FlyMine:FBpp0082832,modMine:FBpp0082832; MD5=d43991b3dea165fea343e48dff6291bd; length=302; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:join(17040847..17040967,17041023..17041705,17041763..17041867); ID=FBpp0082832; name=CG5220-PA; parent=FBgn0038471,FBtr0083391; dbxref=FlyBase:FBpp0082832,FlyBase_Annotation_IDs:CG5220-PA,GB_protein:AAF55380.1,REFSEQ:NP_650590,GB_protein:AAF55380,FlyMine:FBpp0082832,modMine:FBpp0082832; MD5=d43991b3dea165fea343e48dff6291bd; length=302; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0082832 type=protein; loc=3R:join(17040847..17040967,17041023..17041705,17041763..17041867); ID=FBpp0082832; name=CG5220-PA; parent=FBgn0038471,FBtr0083391; dbxref=FlyBase:FBpp0082832,FlyBase_Annotation_IDs:CG5220-PA,GB_protein:AAF55380.1,REFSEQ:NP_650590,GB_protein:AAF55380,FlyMine:FBpp0082832,modMine:FBpp0082832; MD5=d43991b3dea165fea343e48dff6291bd; length=302; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3R:join(17040847..17040967,17041023..17041705,17041763..17041867); ID=FBpp0082832; name=CG5220-PA; parent=FBgn0038471,FBtr0083391; dbxref=FlyBase:FBpp0082832,FlyBase_Annotation_IDs:CG5220-PA,GB_protein:AAF55380.1,REFSEQ:NP_650590,GB_protein:AAF55380,UniProt/Swiss-Prot:Q9VEP1,FlyMine:FBpp0082832,modMine:FBpp0082832; MD5=d43991b3dea165fea343e48dff6291bd; length=302; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 302 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: rRNA methylation [IEA]
    Molecular Function: nucleic acid binding [IEA]
    rRNA (uridine-2'-O-)-methyltransferase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGKTSKDKRD IYYRQAKDEG WRARSAFKLL HVDEAYGILN GVQRAVDLCA APGSWSQVLS  60
   61 RKLYDTCETD DEKSAVKIIA VDLQAMAPIR GILQLQGDIT KQSTAEAIIG HFGGNEKAQL 120
  121 VVCDGAPDVT GVHEMDEYMQ HQLLVAALSI ATCVLETGGT FVAKIFKGNA TSLLSSQMQI 180
  181 FFKKFDIYKP PSSRPSSIEA FVVCSDFCLP EGYIPQVINP ARDDIRLLAQ KTGSEVNRRL 240
  241 VPFIACGDLN GLSDPEEGKT SSSDESKSNL EYVYDAVMDD ASYPLEFKEI LKQVYDEQRH 300
  301 II

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..209] PSI-BLAST 50.39794 RNA methyltransferase FtsJ
    2 View Details [210..302] MSA 4.171996 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • methyltransferase activity
    		•  4.15445027778357 bayes_pls_golite062009
  • rRNA methyltransferase activity
    		•  4.09362182773099 bayes_pls_golite062009
  • N-methyltransferase activity
    		•  4.07806017452628 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  4.07153733729662 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  3.92746815303714 bayes_pls_golite062009
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  3.39429041855776 bayes_pls_golite062009
  • RNA methyltransferase activity
    		•  3.07428840534971 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  2.99461585647365 bayes_pls_golite062009
  • transferase activity
    		•  2.926540904444 bayes_pls_golite062009
  • tRNA methyltransferase activity
    		•  2.5931020126592 bayes_pls_golite062009
  • protein-arginine N-methyltransferase activity
    		•  2.41876112831625 bayes_pls_golite062009
  • arginine N-methyltransferase activity
    		•  2.41876112831625 bayes_pls_golite062009
  • DNA-methyltransferase activity
    		•  2.18991764495147 bayes_pls_golite062009
  • histone-arginine N-methyltransferase activity
    		•  2.04296107639729 bayes_pls_golite062009
  • tRNA (cytosine)-methyltransferase activity
    		•  1.88889414729709 bayes_pls_golite062009
  • tRNA (cytosine-5-)-methyltransferase activity
    		•  1.88889414729709 bayes_pls_golite062009
  • rRNA (adenine) methyltransferase activity
    		•  1.83964463328968 bayes_pls_golite062009
  • rRNA (adenine-N6,N6-)-dimethyltransferase activity
    		•  1.75675289134467 bayes_pls_golite062009
  • protein-arginine omega-N monomethyltransferase activity
    		•  1.66871163498737 bayes_pls_golite062009
  • tRNA (adenine-N1-)-methyltransferase activity
    		•  1.29759910099835 bayes_pls_golite062009
  • tRNA (adenine)-methyltransferase activity
    		•  1.29759910099835 bayes_pls_golite062009
  • catalytic activity
    		•  1.25333584501255 bayes_pls_golite062009
  • histone methyltransferase activity (H4-R3 specific)
    		•  1.1103522853299 bayes_pls_golite062009
  • rRNA (guanine) methyltransferase activity
    		•  1.10713374933008 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.914549843668268 bayes_pls_golite062009
  • protein-arginine omega-N asymmetric methyltransferase activity
    		•  0.89325812193225 bayes_pls_golite062009
  • DNA binding
    		•  0.71058003448013 bayes_pls_golite062009
  • site-specific DNA-methyltransferase (adenine-specific) activity
    		•  0.703178429468566 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.698509190696763 bayes_pls_golite062009
  • RNA binding
    		•  0.417524996559564 bayes_pls_golite062009
  • binding
    		•  0.383237930789959 bayes_pls_golite062009
  • protein-arginine omega-N symmetric methyltransferase activity
    		•  0.364369105571521 bayes_pls_golite062009
  • O-methyltransferase activity
    		•  0.250946859465502 bayes_pls_golite062009
  • rRNA (guanine-N1-)-methyltransferase activity
    		•  0.234572322347698 bayes_pls_golite062009
  • tRNA (guanine) methyltransferase activity
    		•  0.203168546434167 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.90

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle