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Protein Overview: E(spl)-PA

General Information:
Name(s) found: E(spl)-PA / FBpp0084335 [FlyBase]
Description(s) found:
Found 40 descriptions.
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  • The gene Enhancer of split is referred to in FlyBase by the symbol Dmel\E(spl) (CG8365, FBgn0000591). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:21866046..21866585. It has the cytological map location 96F10. There is experimental evidence that it has the molecular function</span>: sequence-specific DNA binding. There is experimental evidence that it is involved in the biological process</span>: sensory organ precursor cell fate determination; compound eye development; dendrite morphogenesis; neuron development; mesoderm development. 79 alleles are reported. The phenotypes of these alleles are annotated with 28 unique terms, many of which group under: peripheral nervous system; nervous system; adult segment; adult mesothoracic segment; organ system; external compound sense organ; gustatory sensory organ; anterior orbital bristle; morphogenetic furrow; external sensory organ precursor cell; late extended germ band embryo. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 179 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEA][NAS]
    Biological Process: epidermal growth factor receptor signaling pathway [NAS]
    mesoderm development [IMP]
    imaginal disc-derived wing margin morphogenesis [NAS]
    peripheral nervous system development [TAS]
    regulation of R8 cell spacing in compound eye [NAS]
    regulation of transcription, DNA-dependent [IEA]
    ectoderm development [TAS]
    neuron development [IMP]
    regulation of transcription [IEA]
    compound eye development [IMP][TAS]
    dendrite morphogenesis [IMP]
    negative regulation of transcription from RNA polymerase II promoter [NAS]
    Notch signaling pathway [NAS]
    sensory organ precursor cell fate determination [IMP]
    cell fate commitment [NAS]
    Molecular Function: DNA binding [NAS]
    transcription factor activity [TAS]
    sequence-specific DNA binding [IDA]
    transcription repressor activity [ISS]
    specific transcriptional repressor activity [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEYTTKTQIY QKVKKPMLER QRRARMNKCL DNLKTLVAEL RGDDGILRMD KAEMLESAVI  60
   61 FMRQQKTPKK VAQEEQSLPL DSFKNGYMNA VNEVSRVMAS TPGMSVDLGK SVMTHLGRVY 120
  121 KNLQQFHEAQ SAADFIQNSM DCSSMDKAPL SPASSGYHSD CDSPAPSPQP MQQPLWRPW

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..76] PSI-BLAST 14.0 SREBP-1a
    2 View Details [77..179] FFAS03 2.8 No description for 2db7A was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle