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Protein Overview: grass-PB

General Information:
Name(s) found: grass-PB / FBpp0084482 [FlyBase]
Description(s) found:
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  • gi|7301554|gb|AAF56675.1| Gram-positive specific serine protease, isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|24650541|ref|NP_651543.1| Gram-positive specific serine protease, isoform B [Drosophila melanogaster] [NCBI NR]
  • The gene Gram-positive Specific Serine protease is referred to in FlyBase by the symbol Dmel\grass (CG5896, FBgn0039494). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:22983668..22985505. It has the cytological map location 97E5. It is reported to have molecular function</span>: serine-type endopeptidase activity. There is experimental evidence that it is involved in the biological process</span>: innate immune response; defense response to Gram-positive bacterium; positive regulation of Toll signaling pathway. 4 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • >CG5896-PB translation from_gene[CG5896 CG5896 FBgn0039494] seq_release:3 mol_weight=41512 cds_boundaries:(3R:22,973,126..22,974,773[+]) aa_length:377 transcript_info:[CG5896-RB seq_release:3] gene_info:[gene symbol:CG5896 FBgn0039494 gene_boundaries:( [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9VB68) CG5896 protein [DrosMelano7227.FASTAC.txt]
  • (AE003759) CG5896 gene product [alt 1] [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG5896-PB, isoform B [Drosophila melanogaster]gi|24650541|ref|NP_651543.1| CG5896-PB [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3R:join(22983761..22983839,22983914..22984086,22984353..22984566,22984625..22984673,22984730..22984923,22984987..22985411); ID=FBpp0084482; name=grass-PB; parent=FBgn0039494,FBtr0085112; dbxref=FlyBase:FBpp0084482,FlyBase_Annotation_IDs: [fly-100309-contam.fasta]
  • CG5896-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=3R:join(22983761..22983839,22983914..22984086,22984353..22984566,22984625..22984673,22984730..22984923,22984987..22985411); ID=FBpp0084482; name=grass-PB; parent=FBgn0039494,FBtr0085112; dbxref=FlyBase:FBpp0084482,FlyBase_Annotation_IDs:CG5896-PB,GB_protein:AAF56675.1,REFSEQ:NP_651543,GB_protein:AAF56675; MD5=1669725b1c0e2a7a14828f1accad6d21; length=377; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:join(22983761..22983839,22983914..22984086,22984353..22984566,22984625..22984673,22984730..22984923,22984987..22985411); ID=FBpp0084482; name=grass-PB; parent=FBgn0039494,FBtr0085112; dbxref=FlyBase:FBpp0084482,FlyBase_Annotation_IDs:CG5896-PB,GB_protein:AAF56675.1,REFSEQ:NP_651543,GB_protein:AAF56675; MD5=1669725b1c0e2a7a14828f1accad6d21; length=377; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Gram-positive specific serine protease, isoform B OS=Drosophila melanogaster GN=grass PE=1 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=3R:join(22983761..22983839,22983914..22984086,22984353..22984566,22984625..22984673,22984730..22984923,22984987..22985411); ID=FBpp0084482; name=grass-PB; parent=FBgn0039494,FBtr0085112; dbxref=FlyBase:FBpp0084482,FlyBase_Annotation_IDs:CG5896-PB,GB_protein:AAF56675.1,REFSEQ:NP_651543,GB_protein:AAF56675,FlyMine:FBpp0084482,modMine:FBpp0084482; MD5=1669725b1c0e2a7a14828f1accad6d21; length=377; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=3R:join(27158039..27158117,27158192..27158364,27158631..27158844,27158903..27158951,27159008..27159201,27159265..27159689); ID=FBpp0084482; name=grass-PB; parent=FBgn0039494,FBtr0085112; dbxref=FlyBase:FBpp0084482,FlyBase_Annotation_IDs:CG5896-PB,GB_protein:AAF56675.1,REFSEQ:NP_651543,GB_protein:AAF56675,FlyMine:FBpp0084482,modMine:FBpp0084482; MD5=1669725b1c0e2a7a14828f1accad6d21; length=377; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:join(27158039..27158117,27158192..27158364,27158631..27158844,27158903..27158951,27159008..27159201,27159265..27159689); ID=FBpp0084482; name=grass-PB; parent=FBgn0039494,FBtr0085112; dbxref=FlyBase:FBpp0084482,FlyBase_Annotation_IDs:CG5896-PB,GB_protein:AAF56675.1,REFSEQ:NP_651543,GB_protein:AAF56675,FlyMine:FBpp0084482,modMine:FBpp0084482; MD5=1669725b1c0e2a7a14828f1accad6d21; length=377; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0084482 type=protein; loc=3R:join(27158039..27158117,27158192..27158364,27158631..27158844,27158903..27158951,27159008..27159201,27159265..27159689); ID=FBpp0084482; name=grass-PB; parent=FBgn0039494,FBtr0085112; dbxref=FlyBase:FBpp0084482,FlyBase_Annotation_IDs:CG5896-PB,GB_protein:AAF56675.1,REFSEQ:NP_651543,GB_protein:AAF56675,FlyMine:FBpp0084482,modMine:FBpp0084482; MD5=1669725b1c0e2a7a14828f1accad6d21; length=377; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3R:join(27158039..27158117,27158192..27158364,27158631..27158844,27158903..27158951,27159008..27159201,27159265..27159689); ID=FBpp0084482; name=grass-PB; parent=FBgn0039494,FBtr0085112; dbxref=FlyBase:FBpp0084482,FlyBase_Annotation_IDs:CG5896-PB,GB_protein:AAF56675.1,REFSEQ:NP_651543,GB_protein:AAF56675,UniProt/TrEMBL:Q9VB68,FlyMine:FBpp0084482,modMine:FBpp0084482; MD5=1669725b1c0e2a7a14828f1accad6d21; length=377; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 377 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: innate immune response [IMP]
    proteolysis [IEA][NAS]
    positive regulation of Toll signaling pathway [IMP]
    defense response to Gram-positive bacterium [IMP]
    Molecular Function: serine-type endopeptidase activity [IEA][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMIASSLAVL YGIAIVSSMG VQSARADYAD DCTTPDGDQG QCMPFSSCRT IEERLTEAQK  60
   61 AGQKVPADYA SYLQKALCGE FNGVRHFCCP SANIQHNSKV MSLFKDENFD CGNFLSQRVS 120
  121 NGYEVKLSSR PWMALLRYQQ FGESRFLCGG AMISERYILT AAHCVHGLQN DLYEIRLGEH 180
  181 RISTEEDCRQ QGRKKKCAPP VVNVGIEKHL IHEKYDARHI MHDIALLKLN RSVPFQKHIK 240
  241 PICLPITDEL KEKAEQISTY FVTGWGTTEN GSSSDVLLQA NVPLQPRSAC SQAYRRAVPL 300
  301 SQLCVGGGDL QDSCKGDSGG PLQAPAQYLG EYAPKMVEFG IVSQGVVTCG QISLPGLYTN 360
  361 VGEYVQWITD TMASNGL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..115] PSI-BLAST 4.39794 No description for 2dohX was found.
    2 View Details [116..377] PSI-BLAST 50.0 No description for 2olgA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • receptor activity
    		•  2.70083456904638 bayes_pls_golite062009
  • signal transducer activity
    		•  2.07627148653165 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.07627148653165 bayes_pls_golite062009
  • binding
    		•  1.90408871052739 bayes_pls_golite062009
  • hydrolase activity
    		•  1.84706864202908 bayes_pls_golite062009
  • peptidase activity
    		•  1.80645788247419 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  1.56029095187292 bayes_pls_golite062009
  • protein binding
    		•  1.52504676895038 bayes_pls_golite062009
  • endopeptidase activity
    		•  1.33798168430886 bayes_pls_golite062009
  • catalytic activity
    		•  0.280235123429996 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle