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Protein Overview: Cyp4ae1-PA

General Information:
Name(s) found: Cyp4ae1-PA / FBpp0070372 [FlyBase]
Description(s) found:
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  • gi|7290281|gb|AAF45742.1| cytochrome P450-4ae1 [Drosophila melanogaster] [NCBI NR]
  • gi|2894116|emb|CAA15700.1| EG:152A3.6 [Drosophila melanogaster] [NCBI NR]
  • gi|18079270|ref|NP_525044.1| cytochrome P450-4ae1 [Drosophila melanogaster] [NCBI NR]
  • gi|16183277|gb|AAL13679.1| GH24265p [Drosophila melanogaster] [NCBI NR]
  • gi|12643563|sp|O46054.1|C4AE1_DROME RecName: Full=Cytochrome P450 4ae1; AltName: Full=CYPIVAE1 [NCBI NR]
  • (O46054) Cytochrome P450 4ae1 (EC 1.14.-.-) (CYPIVAE1) [Swiss-Prot]
  • Cytochrome P450 4ae1 OS=Drosophila melanogaster GN=Cyp4ae1 PE=2 SV=1 [Swiss-Prot]
  • The gene Cytochrome P450-4ae1 is referred to in FlyBase by the symbol Dmel\Cyp4ae1 (CG10755, FBgn0015036). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:2072917..2075034. It has the cytological map location 2E1. Based on sequence similarity, it is predicted to have molecular function</span>: electron carrier activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: oxidation reduction. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG10755-PA translation from_gene[CG10755 Cyp4ae1 FBgn0015036] seq_release:3 mol_weight=56276 cds_boundaries:(X:1,935,869..1,937,526[+]) aa_length:496 transcript_info:[CG10755-RA seq_release:3] gene_info:[gene symbol:Cyp4ae1 FBgn0015036 gene_boundaries [hmr_yeast5_DM3-1_pombe.fasta]
  • (AE003423) Cyp4ae1 gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG10755-PA [Drosophila melanogaster]gi|16183277|gb|AAL13679.1| GH24265p [Drosophila melanogaster]gi|18079270|ref|NP_525044.1| CG10755-PA [Drosophila melanogaster]gi|2894116|emb|CAA15700.1| EG:152A3.6 [Drosophila melanogaster]gi|12643563|sp|O46054|C4AE [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=X:join(2073130..2073295,2073350..2073803,2073859..2074391,2074453..2074790); ID=FBpp0070372; name=Cyp4ae1-PA; parent=FBgn0015036,FBtr0070388; dbxref=FlyBase:FBpp0070372,FlyBase_Annotation_IDs:CG10755-PA,GB_protein:AAF45742.1,REFSEQ:NP_52 [fly-100309-contam.fasta]
  • GH24265p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG10755-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Cytochrome P450-4ae1 CG10755-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • EG:152A3.6 [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Cytochrome P450 4ae1 (CYPIVAE1) [nr-271106-contam.fasta]
  • type=protein; loc=X:join(2073130..2073295,2073350..2073803,2073859..2074391,2074453..2074790); ID=FBpp0070372; name=Cyp4ae1-PA; parent=FBgn0015036,FBtr0070388; dbxref=FlyBase:FBpp0070372,FlyBase_Annotation_IDs:CG10755-PA,GB_protein:AAF45742.1,REFSEQ:NP_525044,GB_protein:AAF45742; MD5=2e49d514e5a84e4b5d2f6281a85fc1d1; length=496; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=X:join(2073130..2073295,2073350..2073803,2073859..2074391,2074453..2074790); ID=FBpp0070372; name=Cyp4ae1-PA; parent=FBgn0015036,FBtr0070388; dbxref=FlyBase:FBpp0070372,FlyBase_Annotation_IDs:CG10755-PA,GB_protein:AAF45742.1,REFSEQ:NP_525044,GB_protein:AAF45742; MD5=2e49d514e5a84e4b5d2f6281a85fc1d1; length=496; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • type=protein; loc=X:join(2073130..2073295,2073350..2073803,2073859..2074391,2074453..2074790); ID=FBpp0070372; name=Cyp4ae1-PA; parent=FBgn0015036,FBtr0070388; dbxref=FlyBase:FBpp0070372,FlyBase_Annotation_IDs:CG10755-PA,GB_protein:AAF45742.1,REFSEQ:NP_525044,GB_protein:AAF45742,FlyMine:FBpp0070372,modMine:FBpp0070372; MD5=2e49d514e5a84e4b5d2f6281a85fc1d1; length=496; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=X:join(2179097..2179262,2179317..2179770,2179826..2180358,2180420..2180757); ID=FBpp0070372; name=Cyp4ae1-PA; parent=FBgn0015036,FBtr0070388; dbxref=FlyBase:FBpp0070372,FlyBase_Annotation_IDs:CG10755-PA,GB_protein:AAF45742.1,REFSEQ:NP_525044,GB_protein:AAF45742,FlyMine:FBpp0070372,modMine:FBpp0070372; MD5=2e49d514e5a84e4b5d2f6281a85fc1d1; length=496; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=X:join(2179097..2179262,2179317..2179770,2179826..2180358,2180420..2180757); ID=FBpp0070372; name=Cyp4ae1-PA; parent=FBgn0015036,FBtr0070388; dbxref=FlyBase:FBpp0070372,FlyBase_Annotation_IDs:CG10755-PA,GB_protein:AAF45742.1,REFSEQ:NP_525044,GB_protein:AAF45742,FlyMine:FBpp0070372,modMine:FBpp0070372; MD5=2e49d514e5a84e4b5d2f6281a85fc1d1; length=496; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0070372 type=protein; loc=X:join(2179097..2179262,2179317..2179770,2179826..2180358,2180420..2180757); ID=FBpp0070372; name=Cyp4ae1-PA; parent=FBgn0015036,FBtr0070388; dbxref=FlyBase:FBpp0070372,FlyBase_Annotation_IDs:CG10755-PA,GB_protein:AAF45742.1,REFSEQ:NP_525044,GB_protein:AAF45742,FlyMine:FBpp0070372,modMine:FBpp0070372; MD5=2e49d514e5a84e4b5d2f6281a85fc1d1; length=496; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=X:join(2179097..2179262,2179317..2179770,2179826..2180358,2180420..2180757); ID=FBpp0070372; name=Cyp4ae1-PA; parent=FBgn0015036,FBtr0070388; dbxref=FlyBase:FBpp0070372,FlyBase_Annotation_IDs:CG10755-PA,GB_protein:AAF45742.1,REFSEQ:NP_525044,GB_protein:AAF45742,UniProt/Swiss-Prot:O46054,FlyMine:FBpp0070372,modMine:FBpp0070372; MD5=2e49d514e5a84e4b5d2f6281a85fc1d1; length=496; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 496 amino acids

    Gene Ontology:
    Cellular Component: membrane [NAS]
    microsome [NAS]
    Biological Process: oxidation reduction [IEA]
    Molecular Function: electron carrier activity [IEA][ISS][NAS]
    monooxygenase activity [IEA]
    heme binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLVVLLVALL VTRLVASLFR LALKELRHPL QGVVPSVSRV PLLGAAWQMR SFQPDNLHDK  60
   61 FAEYVKRFGR SFMGTVLGHV VMVTAEPRHI DALLQGQHQL KKGTMYFALR GWLGDGLLLS 120
  121 RGKEWHTMRK IITPTFHFSI LEQFVEVFDR QSSILVERLR TLSYGNEVVN IYPLVGLAAL 180
  181 DIITETAMGV NVDAQGADSE VVHAVKDLTN ILATRFMRPH LLFPHLFRLC WPSGFRKQQA 240
  241 GVICLHEFTN GIIEQRRRLL AREANQDKPT KPHALLDTLL RATVDGQPLT DKQIRDEVNT 300
  301 FIFEGHDTTT SAVSFCLYLL SRHEAVQQKL FEELRMHYGQ DLFRGVILSD FATLPYLSCV 360
  361 VKESLRLYPP IPAVARCLEK DLVIDEGYIP VGTNVVVLLW QLLRDEAIFT DPLVFQPERH 420
  421 LGEEAPRLSP YSYIPFSAGP RNCIGQKFAL LEMKTMVTKV IRHYQLLPMG ADVEPSIKIV 480
  481 LRSKSGVNVG LRPRLY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..496] PSI-BLAST 98.39794 Crystal Structure of Human Microsomal P450 3A4

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • arachidonic acid monooxygenase activity
    		•  6.76823710927794 bayes_pls_golite062009
  • fatty acid (omega-1)-hydroxylase activity
    		•  6.3313834755701 bayes_pls_golite062009
  • monooxygenase activity
    		•  5.57229509004705 bayes_pls_golite062009
  • steroid hydroxylase activity
    		•  5.04794778387361 bayes_pls_golite062009
  • arachidonic acid epoxygenase activity
    		•  4.80764258881036 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
    		•  4.64322346579269 bayes_pls_golite062009
  • steroid 17-alpha-monooxygenase activity
    		•  3.79253506790596 bayes_pls_golite062009
  • oxygen binding
    		•  3.7203678182299 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
    		•  3.68151610133025 bayes_pls_golite062009
  • fluorene oxygenase activity
    		•  3.16634614522939 bayes_pls_golite062009
  • demethylase activity
    		•  2.80780658333504 bayes_pls_golite062009
  • corticosterone 18-monooxygenase activity
    		•  2.69642243567771 bayes_pls_golite062009
  • steroid 11-beta-monooxygenase activity
    		•  2.69642243567771 bayes_pls_golite062009
  • retinoic acid 4-hydroxylase activity
    		•  2.60901411823382 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
    		•  2.56821164444595 bayes_pls_golite062009
  • thromboxane-A synthase activity
    		•  2.45281910634006 bayes_pls_golite062009
  • oxysterol 7-alpha-hydroxylase activity
    		•  2.36480328243514 bayes_pls_golite062009
  • oxidoreductase activity
    		•  2.35847923992364 bayes_pls_golite062009
  • sterol 14-demethylase activity
    		•  2.33937429425924 bayes_pls_golite062009
  • 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity
    		•  2.30416050662077 bayes_pls_golite062009
  • steroid 7-alpha-hydroxylase activity
    		•  2.21042366294727 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
    		•  2.15105968497418 bayes_pls_golite062009
  • arachidonic acid 11,12-epoxygenase activity
    		•  2.0071742914584 bayes_pls_golite062009
  • ecdysteroid 25-hydroxylase activity
    		•  2.0071742914584 bayes_pls_golite062009
  • retinoid binding
    		•  1.91237853759594 bayes_pls_golite062009
  • vitamin D 24-hydroxylase activity
    		•  1.81919676974797 bayes_pls_golite062009
  • isoprenoid binding
    		•  1.78853880472253 bayes_pls_golite062009
  • retinoic acid binding
    		•  1.69236715381231 bayes_pls_golite062009
  • vitamin D3 25-hydroxylase activity
    		•  1.65825585934141 bayes_pls_golite062009
  • vitamin D 25-hydroxylase activity
    		•  1.65825585934141 bayes_pls_golite062009
  • electron carrier activity
    		•  1.48516712188486 bayes_pls_golite062009
  • testosterone 6-beta-hydroxylase activity
    		•  1.4661447981611 bayes_pls_golite062009
  • binding
    		•  1.2866152532988 bayes_pls_golite062009
  • 25-hydroxycholecalciferol-24-hydroxylase activity
    		•  1.06487564122685 bayes_pls_golite062009
  • flavonoid 3'-monooxygenase activity
    		•  0.89030345144459 bayes_pls_golite062009
  • iron ion binding
    		•  0.834040060319729 bayes_pls_golite062009
  • transition metal ion binding
    		•  0.780604486782617 bayes_pls_golite062009
  • cation binding
    		•  0.780350495727298 bayes_pls_golite062009
  • metal ion binding
    		•  0.780350495727298 bayes_pls_golite062009
  • ion binding
    		•  0.773102216481016 bayes_pls_golite062009
  • ecdysteroid 22-hydroxylase activity
    		•  0.7601272997427 bayes_pls_golite062009
  • catalytic activity
    		•  0.608111453189583 bayes_pls_golite062009
  • cholesterol monooxygenase (side-chain-cleaving) activity
    		•  0.276594551871869 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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