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Protein Overview: Hexo2-PA

General Information:
Name(s) found: Hexo2-PA / FBpp0071192 [FlyBase]
Description(s) found:
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  • gi|7290966|gb|AAF46406.1| hexosaminidase 2 [Drosophila melanogaster] [NCBI NR]
  • gi|21392072|gb|AAM48390.1| RE07082p [Drosophila melanogaster] [NCBI NR]
  • gi|17933586|ref|NP_525081.1| hexosaminidase 2 [Drosophila melanogaster] [NCBI NR]
  • The gene Hexosaminidase 2 is referred to in FlyBase by the symbol Dmel\Hexo2 (CG1787, FBgn0041629). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:8603687..8606515. It has the cytological map location 8A2. There is experimental evidence that it has the molecular function</span>: beta-N-acetylglucosaminidase activity. There is experimental evidence that it is involved in the biological process</span>: negative regulation of growth or development of symbiont in host. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG1787-PA translation from_gene[CG1787 Hexo2 FBgn0041629] seq_release:3 mol_weight=70664 cds_boundaries:(X:8,448,808..8,451,360[+]) aa_length:622 transcript_info:[CG1787-RA seq_release:3] gene_info:[gene symbol:Hexo2 FBgn0041629 gene_boundaries:(X:8,4 [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9W3C4) Putative beta-N-acetylhexosaminidase HEXO2 (EC 3.2.1.52) (RE07082p) [DrosMelano7227.FASTAC.txt]
  • (AE003444) Hexo2 gene product [alt 2] [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG1787-PA [Drosophila melanogaster]gi|21392072|gb|AAM48390.1| RE07082p [Drosophila melanogaster]gi|17933586|ref|NP_525081.1| CG1787-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=X:join(8603842..8603990,8604608..8606145,8606216..8606397); ID=FBpp0071192; name=Hexo2-PA; parent=FBgn0041629,FBtr0071249; dbxref=FlyBase:FBpp0071192,FlyBase_Annotation_IDs:CG1787-PA,GB_protein:AAF46406.1,REFSEQ:NP_525081,GB_protein:AAF4 [fly-100309-contam.fasta]
  • Hexosaminidase 2 CG1787-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • RE07082p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG1787-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=X:join(8603842..8603990,8604608..8606145,8606216..8606397); ID=FBpp0071192; name=Hexo2-PA; parent=FBgn0041629,FBtr0071249; dbxref=FlyBase:FBpp0071192,FlyBase_Annotation_IDs:CG1787-PA,GB_protein:AAF46406.1,REFSEQ:NP_525081,GB_protein:AAF46406; MD5=053b9c70452f6fd1fc8e3371c5ba43e4; length=622; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=X:join(8603842..8603990,8604608..8606145,8606216..8606397); ID=FBpp0071192; name=Hexo2-PA; parent=FBgn0041629,FBtr0071249; dbxref=FlyBase:FBpp0071192,FlyBase_Annotation_IDs:CG1787-PA,GB_protein:AAF46406.1,REFSEQ:NP_525081,GB_protein:AAF46406; MD5=053b9c70452f6fd1fc8e3371c5ba43e4; length=622; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Hexosaminidase 2 OS=Drosophila melanogaster GN=Hexo2 PE=2 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=X:join(8603842..8603990,8604608..8606145,8606216..8606397); ID=FBpp0071192; name=Hexo2-PA; parent=FBgn0041629,FBtr0071249; dbxref=FlyBase:FBpp0071192,FlyBase_Annotation_IDs:CG1787-PA,GB_protein:AAF46406.1,REFSEQ:NP_525081,GB_protein:AAF46406,FlyMine:FBpp0071192,modMine:FBpp0071192; MD5=053b9c70452f6fd1fc8e3371c5ba43e4; length=622; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=X:join(8709809..8709957,8710575..8712112,8712183..8712364); ID=FBpp0071192; name=Hexo2-PA; parent=FBgn0041629,FBtr0071249; dbxref=FlyBase:FBpp0071192,FlyBase_Annotation_IDs:CG1787-PA,GB_protein:AAF46406.1,REFSEQ:NP_525081,GB_protein:AAF46406,FlyMine:FBpp0071192,modMine:FBpp0071192; MD5=053b9c70452f6fd1fc8e3371c5ba43e4; length=622; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=X:join(8709809..8709957,8710575..8712112,8712183..8712364); ID=FBpp0071192; name=Hexo2-PA; parent=FBgn0041629,FBtr0071249; dbxref=FlyBase:FBpp0071192,FlyBase_Annotation_IDs:CG1787-PA,GB_protein:AAF46406.1,REFSEQ:NP_525081,GB_protein:AAF46406,FlyMine:FBpp0071192,modMine:FBpp0071192; MD5=053b9c70452f6fd1fc8e3371c5ba43e4; length=622; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Hexosaminidase 2 OS=Drosophila melanogaster GN=Hexo2 PE=1 SV=1 [DROME.fasta.20160308]
  • FBpp0071192 type=protein; loc=X:join(8709809..8709957,8710575..8712112,8712183..8712364); ID=FBpp0071192; name=Hexo2-PA; parent=FBgn0041629,FBtr0071249; dbxref=FlyBase:FBpp0071192,FlyBase_Annotation_IDs:CG1787-PA,GB_protein:AAF46406.1,REFSEQ:NP_525081,GB_protein:AAF46406,FlyMine:FBpp0071192,modMine:FBpp0071192; MD5=053b9c70452f6fd1fc8e3371c5ba43e4; length=622; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=X:join(8709809..8709957,8710575..8712112,8712183..8712364); ID=FBpp0071192; name=Hexo2-PA; parent=FBgn0041629,FBtr0071249; dbxref=FlyBase:FBpp0071192,FlyBase_Annotation_IDs:CG1787-PA,GB_protein:AAF46406.1,REFSEQ:NP_525081,GB_protein:AAF46406,UniProt/TrEMBL:Q9W3C4,FlyMine:FBpp0071192,modMine:FBpp0071192; MD5=053b9c70452f6fd1fc8e3371c5ba43e4; length=622; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 622 amino acids

    Gene Ontology:
    Cellular Component: plasma membrane [IDA]
    Biological Process: carbohydrate metabolic process [IEA]
    Molecular Function: beta-N-acetylglucosaminidase activity [IDA]
    cation binding [IEA]
    beta-N-acetylhexosaminidase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRFSGYNRYQ CFCSAVGSLL LLSLLSFAVG AALTRADDVG SDADAGSASR KWLCSRTDIC  60
   61 TAEGEMVAGL QYAPEIFESQ RDCRLSCGKY GAIWPMPTGK ECTISHRRVR FDPWKVRFHV 120
  121 VAPGEAATQF LRETNRLFVS NLLKECIRNC TLETSKQILV RSTVANESLV LDWPTDESYA 180
  181 LVVRTTETAT FVDIQATTVY GARHAFETLS NLVTGSLSNG LLMVTTANIT DRPAFSHRGV 240
  241 LLDTARNFVP LKFIRSTLDA MAASKLNVLH WHVVDTHSFP LEITRVPEMQ RYGAYSSSQT 300
  301 YSRQDALNLV KYARLRGIRI LIEIDGPSHA GNGWQWGPAA GLGNMSVCLN QSPWRRFCVQ 360
  361 PPCGQLNPLN DHMYAVLKEI FEDVAEVGAP EETLHMGGDE VFLPCWNNTD EIRDGMRARG 420
  421 YDLSEQSFLR LWSQFHQRNL NAWDEINERM YPGIKEPKSV IIWSSHLTNP RYIETYLPKE 480
  481 RFIIQTWVES QDALNRELLQ RGYRLIVSTK NAWYLDHGFW GSTSYYNWRT VYSSGMPVGR 540
  541 SKDQVLGGEV CMWSEYVDQN SLESRIWPRA GAAAERMWSN PKSSALLAQR RFYRYRERLL 600
  601 ARGIHADAVI PHWCVLHEGQ CL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..88] MSA 1.108988 View MSA. No confident structure predictions are available.
    2 View Details [89..622] PSI-BLAST 130.0 Human beta-Hexosaminidase B

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • hydrolase activity, hydrolyzing O-glycosyl compounds
    		•  6.26329339735894 bayes_pls_golite062009
  • hydrolase activity, acting on glycosyl bonds
    		•  5.92180849080637 bayes_pls_golite062009
  • chitinase activity
    		•  5.52705867024 bayes_pls_golite062009
  • galactosidase activity
    		•  5.29959220339307 bayes_pls_golite062009
  • alpha-galactosidase activity
    		•  4.85819791163713 bayes_pls_golite062009
  • hydrolase activity
    		•  3.5336140444552 bayes_pls_golite062009
  • hexosaminidase activity
    		•  3.21852337137039 bayes_pls_golite062009
  • mannosidase activity
    		•  2.76650385192253 bayes_pls_golite062009
  • beta-N-acetylhexosaminidase activity
    		•  2.69072465526737 bayes_pls_golite062009
  • transferase activity, transferring hexosyl groups
    		•  2.06059323252952 bayes_pls_golite062009
  • glucosidase activity
    		•  1.92306554001182 bayes_pls_golite062009
  • catalytic activity
    		•  1.85569074294201 bayes_pls_golite062009
  • alpha-amylase activity
    		•  1.42264105957213 bayes_pls_golite062009
  • amylase activity
    		•  1.37652764526134 bayes_pls_golite062009
  • chitin binding
    		•  1.29046765706168 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.934517587656668 bayes_pls_golite062009
  • signal transducer activity
    		•  0.934517587656668 bayes_pls_golite062009
  • transporter activity
    		•  0.882190348056302 bayes_pls_golite062009
  • beta-mannosidase activity
    		•  0.858618539860091 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.696239852087965 bayes_pls_golite062009
  • binding
    		•  0.601963252939415 bayes_pls_golite062009
  • beta-glucuronidase activity
    		•  0.55376725638834 bayes_pls_golite062009
  • alpha-glucosidase activity
    		•  0.502835520523619 bayes_pls_golite062009
  • receptor binding
    		•  0.497417763506343 bayes_pls_golite062009
  • beta-N-acetylglucosaminidase activity
    		•  0.489832278458081 bayes_pls_golite062009
  • transferase activity, transferring glycosyl groups
    		•  0.23234868908353 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.223550370855368 bayes_pls_golite062009
  • carbohydrate binding
    		•  0.102788238231918 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  7.36798954279472E-5 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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