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Protein Overview: unc-6

General Information:
Name(s) found: unc-6 / CE04538 [WormBase]
Description(s) found:
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  • WBGene00006746 locus:unc-6 Netrin unc-6 status:Confirmed UniProt:P34710 protein_id:CCD67895.1 [WormBase]
  • gi|465001|sp|P34710.1|UNC6_CAEEL RecName: Full=Netrin unc-6; AltName: Full=Uncoordinated protein 6; Flags: Precursor [NCBI NR]
  • pir||JH0799 laminin-related protein UNC-6 precursor - Caenorhabditis elegans [NCBI NR]
  • gi|289724|gb|AAA28157.1| unc-6 [Caenorhabditis elegans] [NCBI NR]
  • gi|17570167|ref|NP_509165.1| UNCoordinated family member (unc-6) [Caenorhabditis elegans] [NCBI NR]
  • gi|1049477|gb|AAA80449.1| Uncoordinated protein 6, partially confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • Netrin unc-6 OS=Caenorhabditis elegans GN=unc-6 PE=1 SV=1 [Swiss-Prot]
  • [wormpep67.fasta]
  • CE04538 WBGene00006746 locus:unc-6 status:Partially_confirmed SW:P34710 protein_id:AAA80449.1 [wormpep150.fasta]
  • 04538 WBGene00006746 locus:unc-6 status:Partially_confirmed SW:P34710 protein_id:AAA80449.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • UNCoordinated locomotion UNC-6, netrin (68.4 kD) (unc-6) [Caenorhabditis elegans]gi|1049477|gb|AAA80449.1| Uncoordinated protein 6 [Caenorhabditis elegans]gi|345365|pir||JH0799 laminin-related protein UNC-6 precursor - Caenorhabditis elegansgi|465001|s [nrdb_11152004_Chlamydomonas]
  • locus:unc-6 status:Partially_confirmed SW:P34710 protein_id:AAA80449.1 [wormpep115.fasta.reversed]
  • CE04538 locus:unc-6 status:Partially_confirmed [wormpep80.hongbin]
  • CE04538 WBGene00006746 locus:unc-6 status:Partially_confirmed UniProt:UNC6_CAEEL protein_id:AAA80449.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE04538 WBGene00006746 locus:unc-6 status:Partially_confirmed UniProt:UNC6_CAEEL protein_id:AAA80449.1| [wormORF-contam.fasta]
  • Netrin unc-6 precursor (Uncoordinated protein 6) [nr-271106-contam.fasta]
  • Uncoordinated protein 6 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • UNCoordinated family member (unc-6) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • unc-6 [nr-271106-contam.fasta]
  • CE04538 WBGene00006746 locus:unc-6 status:Confirmed UniProt:P34710 protein_id:AAA80449.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE04538 WBGene00006746 locus:unc-6 status:Confirmed UniProt:P34710 protein_id:CCD67895.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE04538 WBGene00006746 locus:unc-6 status:Confirmed UniProt:P34710 protein_id:CCD67895.1 Netrin unc-6 [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 612 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    axon [IDALink to PubMed article]
    proteinaceous extracellular matrix [IEALink to PubMed article]
    Biological Process: locomotory behavior [IMPLink to PubMed article]
    mesodermal cell migration [IMPLink to PubMed article]
    gonad morphogenesis [IGILink to PubMed article][IMPLink to PubMed article]
    axon guidance [IMPLink to PubMed article]
    regulation of cell migration [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: receptor binding [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MITSVLRYVL ALYFCMGIAH GAYFSQFSMR APDHDPCHDH TGRPVRCVPE FINAAFGKPV  60
   61 IASDTCGTNR PDKYCTVKEG PDGIIREQCD TCDARNHFQS HPASLLTDLN SIGNMTCWVS 120
  121 TPSLSPQNVS LTLSLGKKFE LTYVSMHFCS RLPDSMALYK SADFGKTWTP FQFYSSECRR 180
  181 IFGRDPDVSI TKSNEQEAVC TASHIMGPGG NRVAFPFLEN RPSAQNFENS PVLQDWVTAT 240
  241 DIKVVFSRLS PDQAELYGLS NDVNSYGNET DDEVKQRYFY SMGELAVGGR CKCNGHASRC 300
  301 IFDKMGRYTC DCKHNTAGTE CEMCKPFHYD RPWGRATANS ANSCVACNCN QHAKRCRFDA 360
  361 ELFRLSGNRS GGVCLNCRHN TAGRNCHLCK PGFVRDTSLP MTHRKACKSC GCHPVGSLGK 420
  421 SCNQSSGQCV CKPGVTGTTC NRCAKGYQQS RSTVTPCIKI PTKADFIGSS HSEEQDQCSK 480
  481 CRIVPKRLNQ KKFCKRDHAV QMVVVSREMV DGWAKYKIVV ESVFKRGTEN MQRGETSLWI 540
  541 SPQGVICKCP KLRVGRRYLL LGKNDSDHER DGLMVNPQTV LVEWEDDIMD KVLRFSKKDK 600
  601 LGQCPEITSH RY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..351] FFAS03 1.07 Crystal structure of the RNA subunit of Ribonuclease P. Bacterial A-type.
    2 View Details [352..525] PSI-BLAST 6.39794 Crystal structure of Nidogen/Laminin Complex
    3 View Details [526..612] FFAS03 4.53 Procollagen c-proteinase enhancer protein PCOLCE

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • metalloendopeptidase inhibitor activity
    		•  2.93008814424574 bayes_pls_golite062009
  • metalloenzyme regulator activity
    		•  2.93008814424574 bayes_pls_golite062009
  • metalloenzyme inhibitor activity
    		•  2.93008814424574 bayes_pls_golite062009
  • cytokine activity
    		•  2.1026057983858 bayes_pls_golite062009
  • protein binding
    		•  1.99085018021326 bayes_pls_golite062009
  • chemokine activity
    		•  1.91192407750516 bayes_pls_golite062009
  • chemokine receptor binding
    		•  1.91192407750516 bayes_pls_golite062009
  • binding
    		•  1.76357208140123 bayes_pls_golite062009
  • receptor binding
    		•  1.70988428101653 bayes_pls_golite062009
  • G-protein-coupled receptor binding
    		•  1.33224850209979 bayes_pls_golite062009
  • endopeptidase inhibitor activity
    		•  1.31068274422963 bayes_pls_golite062009
  • peptidase inhibitor activity
    		•  1.26079752095237 bayes_pls_golite062009
  • enzyme inhibitor activity
    		•  1.2236133281236 bayes_pls_golite062009
  • protein complex binding
    		•  0.314497759083213 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle