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Protein Overview: dhp-2

General Information:
Name(s) found: dhp-2 / CE05452 [WormBase]
Description(s) found:
Found 22 descriptions.
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  • WBGene00000964 locus:dhp-2 Dihydropyrimidinase 2 status:Confirmed UniProt:Q18677 protein_id:CAA93104.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 520 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article][IEALink to PubMed article]
    Biological Process: pyrimidine base catabolic process [IDALink to PubMed article]
    nucleobase catabolic process [ISSLink to PubMed article]
    histidine catabolic process to glutamate and formamide [IEALink to PubMed article]
    Molecular Function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [IDALink to PubMed article][IEALink to PubMed article]
    dihydropyrimidinase activity [ISSLink to PubMed article]
    hydrolase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLLIKNGTI VNDDAIFKSD VLVLDGRIVE IAPSIQPTPG LEVVDATDRL VIPGGIDPHT  60
   61 HMQLPFMGEI AKDDFHRGTE AAVAGGTTMI IDFVIPTKGE SLLVAYDRWR GWADPKVVCD 120
  121 YGLSMAITSW GPEIAKEMEI VTGAEYGINS FKFFLAYAGV FMVRDEEFYQ GMIQCAKLRA 180
  181 LARVHAENGS VIAERCEHLL SSGITGPEGH TQSRPEELEA EATFRACTMA SQANCPLYVV 240
  241 HVMSKGAAAA IAHHRKKGAV VFGEPIAAGL ATDGSHYYNE DWLHAARYVM SPPLSRDPST 300
  301 PSALMKLLAA GELHLTATDN CTFDCQQKSL GKDDFTKIPN GVNGVEDRMS VVWDKGVHAG 360
  361 IIDPMRFVAV TSTMAAKIFN CYPQKGRIAV GSDADIVIWN ANATRTISKD THHHAIDFNI 420
  421 FEGMQVHGVP EITISRGRTV WANGQLKTVQ GSGQFIPLAP DSQIVFSAVD NRKKAMEPVK 480
  481 IDRIPYEPSA LQTPDANANI VVKAPVRAAI PPGGASSIQF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..520] PSI-BLAST 102.0 No description for 2ftwA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • dihydropyrimidinase activity
    		•  5.22180471926674 bayes_pls_golite062009
  • uracil binding
    		•  2.6045173443981 bayes_pls_golite062009
  • pyrimidine binding
    		•  2.6045173443981 bayes_pls_golite062009
  • hydrolase activity
    		•  2.54288207838687 bayes_pls_golite062009
  • allantoinase activity
    		•  2.45571277189844 bayes_pls_golite062009
  • dihydroorotase activity
    		•  2.32070383330692 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
    		•  2.20489529944693 bayes_pls_golite062009
  • deaminase activity
    		•  1.79186203771221 bayes_pls_golite062009
  • catalytic activity
    		•  1.70199291046899 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  1.60895003474033 bayes_pls_golite062009
  • adenine deaminase activity
    		•  1.4081199504179 bayes_pls_golite062009
  • thymine binding
    		•  1.34528530211689 bayes_pls_golite062009
  • binding
    		•  0.778600467259354 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
    		•  0.573107361273483 bayes_pls_golite062009
  • guanine deaminase activity
    		•  0.134430884998957 bayes_pls_golite062009
  • purine nucleoside binding
    		•  0.015278392159201 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle