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Protein Overview: lin-23

General Information:
Name(s) found: lin-23 / CE28600 [WormBase]
Description(s) found:
Found 22 descriptions.
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  • WBGene00003009 locus:lin-23 F-box\/WD repeat-containing protein lin-23 status:Confirmed UniProt:Q09990 protein_id:CCD66391.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 665 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: negative regulation of multicellular organism growth [IMPLink to PubMed articleLink to PubMed article]
    locomotory behavior [IMPLink to PubMed article]
    hermaphrodite genitalia development [IMPLink to PubMed article]
    nematode larval development [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    negative regulation of cell proliferation [IMPLink to PubMed articleLink to PubMed article]
    positive regulation of growth rate [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    post-embryonic body morphogenesis [IMPLink to PubMed article]
    neuron projection morphogenesis [IMPLink to PubMed article]
    growth [IMPLink to PubMed article]
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSPHRASTT QQLADLSLTE GEHDEGKPLS IDYLQGHEGL IEEVLKWSEH EQLDFMDKIV  60
   61 HRLSHYQLGK VDNFIRPMLQ RDFISNLPAH LVELILFNVN SDSLKSCEEV STSWRCALAR 120
  121 GQHWKKLIEK NVRSDSLWWG LSEKRQWDKF LNISRDMSVR RICEKFNYDV NIKRDKLDQL 180
  181 ILMHVFYSKL YPKIIRDIHN IDNNWKRGNY KMTRINCQSE NSKGVYCLQY DDDKIVSGLR 240
  241 DNTIKIWDRK DYSCSRILSG HTGSVLCLQY DNRVIISGSS DATVRVWDVE TGECIKTLIH 300
  301 HCEAVLHLRF ANGIMVTCSK DRSIAVWDMV SPRDITIRRV LVGHRAAVNV VDFDDRYIVS 360
  361 ASGDRTIKVW SMDTLEFVRT LAGHRRGIAC LQYRGRLVVS GSSDNTIRLW DIHSGVCLRV 420
  421 LEGHEELVRC IRFDEKRIVS GAYDGKIKVW DLQAALDPRA LSSEICLCSL VQHTGRVFRL 480
  481 QFDDFQIVSS SHDDTILIWD FLDAPPSGLP SSTNRATLPE LPNQAAVARA QMLFEMAARR 540
  541 EIERRDREVV EEPALRPRAN AARRHNADIA AAAAAAEAAR GAGDNDESSS EEDLDRVDQV 600
  601 NNPNVAGPAP PQPHNQNHRR RQPRPELPVR LMQEMAAFDN MRRQQNNMDH LGGGDVDEEM 660
  661 PDGGP

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..127] PSI-BLAST 5.522879 Tricorn protease; Tricorn protease N-terminal domain; Tricorn protease domain 2
    2 View Details [128..665] PSI-BLAST 52.522879 Actin interacting protein 1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • hydrolase activity
    		•  1.29702012649067 bayes_pls_golite062009
  • peptidase activity
    		•  0.990550688241572 bayes_pls_golite062009
  • catalytic activity
    		•  0.60409960326459 bayes_pls_golite062009
    2
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  7.6976390971701 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  7.38724968585043 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  6.41826641115519 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  5.36089569430187 bayes_pls_golite062009
  • actin binding
    		•  3.31804728298431 bayes_pls_golite062009
  • GTPase activity
    		•  3.23750443966606 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  3.1056443224755 bayes_pls_golite062009
    		• 2.92359149151424 bayes_pls_golite062009
  • tubulin binding
    		•  2.76945430061825 bayes_pls_golite062009
  • microtubule binding
    		•  2.72684103222924 bayes_pls_golite062009
  • dynein binding
    		•  2.54821997913979 bayes_pls_golite062009
  • binding
    		•  2.42570478946173 bayes_pls_golite062009
  • RNA binding
    		•  2.1927334052131 bayes_pls_golite062009
  • dynactin binding
    		•  1.92897254169098 bayes_pls_golite062009
  • ligase activity
    		•  1.82531515493699 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.63776917287392 bayes_pls_golite062009
  • G-protein-coupled receptor binding
    		•  1.63631972867316 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.56901113625383 bayes_pls_golite062009
  • actin filament binding
    		•  1.5197243426595 bayes_pls_golite062009
  • protein binding
    		•  1.21879977456466 bayes_pls_golite062009
  • transporter activity
    		•  1.21549336905926 bayes_pls_golite062009
  • receptor activity
    		•  1.12819778129653 bayes_pls_golite062009
  • DNA binding
    		•  1.0776875611211 bayes_pls_golite062009
  • microtubule plus-end binding
    		•  1.01166033978052 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.974380908248463 bayes_pls_golite062009
  • signal transducer activity
    		•  0.974380908248463 bayes_pls_golite062009
  • type 1 angiotensin receptor binding
    		•  0.920323565472959 bayes_pls_golite062009
  • angiotensin receptor binding
    		•  0.920323565472959 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.826090766828089 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.734793983890004 bayes_pls_golite062009
  • snoRNA binding
    		•  0.637990433340251 bayes_pls_golite062009
  • transcription factor activity
    		•  0.541665384827041 bayes_pls_golite062009
  • dynein intermediate chain binding
    		•  0.443846546939402 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.426429095658617 bayes_pls_golite062009
  • kinase activity
    		•  0.387572734234845 bayes_pls_golite062009
  • receptor binding
    		•  0.316169754698691 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.259860754265901 bayes_pls_golite062009
  • structural molecule activity
    		•  0.254012051644049 bayes_pls_golite062009
  • transcription factor binding
    		•  0.244641056034795 bayes_pls_golite062009
  • protein kinase activity
    		•  0.229242350006544 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.226335610368636 bayes_pls_golite062009
  • hydrolase activity
    		•  0.181211933860468 bayes_pls_golite062009
  • histone binding
    		•  0.166694897714113 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.118975415284669 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.0160791658499004 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.00585398682921312 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle