Protein Overview: FAK1_RAT

General Information:
Name(s) found:	FAK1_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|6981440\|ref\|NP_037213.1\| PTK2 protein tyrosine kinase 2 [Rattus norvegicus] [NCBI NR] gi\|3182997\|sp\|O35346.1\|FAK1_RAT RecName: Full=Focal adhesion kinase 1; Short=FADK 1; AltName: Full=pp125FAK [NCBI NR] gi\|2465667\|gb\|AAB72203.1\| focal adhesion kinase; pp125FAK [Rattus norvegicus] [NCBI NR] Focal adhesion kinase 1 OS=Rattus norvegicus GN=Ptk2 PE=1 SV=1 [Swiss-Prot] protein tyrosine kinase 2; Protein tyrosine kinase; focal adhesion kinase; focal adhesion kinase-related nonkinase [HMR_022704-rand.fasta] PTK2 protein tyrosine kinase 2 [Rattus norvegicus]gi\|2465667\|gb\|AAB72203.1\| focal adhesion kinase; pp125FAK [Rattus norvegicus]gi\|3182997\|sp\|O35346\|FAK1_RAT Focal adhesion kinase 1 (FADK 1) (pp125FAK) [nrdb_11152004_Chlamydomonas] (NM_013081) protein tyrosine kinase [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] Tax_Id=10116 Focal adhesion kinase 1 [EBI-IPI_rat_3.05_04-04-2005_origrev.fasta] Focal adhesion kinase 1 (FADK 1) (pp125FAK) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] PTK2 protein tyrosine kinase 2 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] focal adhesion kinase; pp125FAK [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 FOCAL ADHESION KINASE 1 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Focal adhesion kinase 1 OS=Rattus norvegicus GN=Ptk2 [011711_HMR.fasta] Isoform of O35346, Focal adhesion kinase 1 OS=Rattus norvegicus GN=Ptk2 PE=1 SV=2 [RAT.fasta.20160308]
Organism:	Rattus norvegicus
Length:	1055 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] cytoskeleton [IEA] nuclear body [IDA] focal adhesion [UNKNOWN][IDA][IEA][TAS] cytoplasm [UNKNOWN] sarcolemma [IDA] cytosol [UNKNOWN] intercalated disc [IDA] nucleolus [IDA] basolateral plasma membrane [IDA] apical plasma membrane [UNKNOWN][IDA] lamellipodium [UNKNOWN]
Biological Process:	signal complex assembly [IEA] central nervous system neuron axonogenesis [UNKNOWN] positive regulation of vasodilation [IMP] protein amino acid autophosphorylation [UNKNOWN] JNK cascade [IMP] vasculogenesis [UNKNOWN] endothelial cell migration [UNKNOWN] fat cell differentiation [IEP] positive regulation of cell adhesion [IMP] protein amino acid phosphorylation [IEA] response to mechanical stimulus [IEP] positive regulation of smooth muscle cell proliferation [IMP] MAPKKK cascade [IMP] neuron migration [UNKNOWN] response to glucose stimulus [IEP] positive regulation of cell growth [IMP] negative regulation of axonogenesis [UNKNOWN] blood vessel development [UNKNOWN] angiogenesis [UNKNOWN] response to arsenic [IEP] positive regulation of smooth muscle cell migration [IMP] cellular chloride ion homeostasis [IMP] negative regulation of synaptogenesis [UNKNOWN] response to organic substance [IEP] establishment of nucleus localization [UNKNOWN] positive regulation of synaptic transmission [IMP] positive regulation of glial cell proliferation [IMP] microtubule cytoskeleton organization [UNKNOWN] response to organic cyclic substance [IEP] negative regulation of organ growth [UNKNOWN] response to drug [IEP] negative regulation of apoptosis [IMP] extracellular matrix organization [UNKNOWN] response to estradiol stimulus [IEP] positive regulation of phagocytosis [IMP] response to organic nitrogen [IEP] negative regulation of cell migration [IMP] positive regulation of cell migration [IMP]
Molecular Function:	ATP binding [IEA] protein tyrosine kinase activity [IEA][TAS] protein binding [UNKNOWN][IDA][IEA] protein kinase activity [IEA] protein complex binding [IPI] SH2 domain binding [UNKNOWN] signal transducer activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAAYLDPNL NHTPSSSTKT HLGTGTERSP GAMERVLKVF HYFESSNEPT TWASIIRHGD  60
   61 ATDVRGIIQK IVDSHKVKHV ACYGFRLSHL RSEEVHWLHV DMGVSSVREK YELAHPPEEW 120
  121 KYELRIRYLP KGFLNQFTED KPTLNFFYQQ VKSDYMLEIA DQVDQDIALK LGCLEIRRSY 180
  181 WEMRGNALEK KSNYEVLEKD VGLKRFFPKS LLDSVKAKTL RKLIQQTFRQ FANLNREESI 240
  241 LKFFEILSPV YRFDKECFKC ALGSSWIISV ELAIGPEEGI SYLTDKGCNP THLADFNQVQ 300
  301 TIQYSNSEDK DRKGMLQLKI AGAPEPLTVT APSLTIAENM ADLIDGYCRL VNGATQSFII 360
  361 RPQKEGERAL PSIPKLANNE KQGMRTHAVS VSETDDYAEI IDEEDTYTMP STRDYEIQRE 420
  421 RIELGRCIGE GQFGDVHQGV YLSPENPALA VAIKTCKNCT SDSVREKFLQ EALTMRQFDH 480
  481 PHIVKLIGVI TENPVWIIME LCTLGELRSF LQVRKYSLDL ASLILYAYQL STALAYLESK 540
  541 RFVHRDIAAR NVLVSSNDCV KLGDFGLSRY MEDSTYYKAS KGKLPIKWMA PESINFRRFT 600
  601 SASDVWMFGV CMWEILMHGV KPFQGVKNND VIGRIENGER LPMPPNCPPT LYSLMTKCWA 660
  661 YDPSRRPRFT ELKAQLSTIL EEEKVQQEER MRMESRRQAT VSWDSGGSDE APPKPSRPGY 720
  721 PSPRSSEGFY PSPQHMVQTN HYQISGYPGS HGIPAMAGSI YPGQASLLDQ TELWNHRPQE 780
  781 MSMWQPSVED SAALDLRGMG QVLPPHLMEE RLIRQQQEME EDQRWLEKEE RFLKPDVRLS 840
  841 RGSIDREDGS FQGPTGNQHI YQPVGKPDPA APPKKPPRPG APGHLSNLSS ISSPAESYNE 900
  901 GVKPWRLQPQ EISPPPTANL DRSNDKVYEN VTGLVKAVIE MSSKIQPAPP EEYVPMVKEV 960
  961 GLALRTLLAT VDETIPILPA STHREIEMAQ KLLNSDLGEL ISKMKLAQQY VMTSLQQEYK1020
 1021 KQMLTAAHAL AVDAKNLLDV IDQARLKMLG QTRPH

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.97

Protein Overview: FAK1_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: