Protein Overview: NSUN2

General Information:
Name(s) found:	NSUN2 [HGNC (HUGO)]
Description(s) found: SHOW ONLY BEST	gi\|39995082\|ref\|NP_060225.4\| NOL1/NOP2/Sun domain family, member 2 [Homo sapiens] [NCBI NR] gi\|187950511\|gb\|AAI37084.1\| NOL1/NOP2/Sun domain family, member 2 [Homo sapiens] [NCBI NR] gi\|148887180\|sp\|Q08J23.2\|NSUN2_HUMAN RecName: Full=tRNA (cytosine-5-)-methyltransferase NSUN2; AltName: Full=NOL1/NOP2/Sun domain family member 2; AltName: Full=tRNA (cytosine-5-)-methyltransferase; AltName: Full=tRNA methyltransferase 4 homolog; Short=hT [NCBI NR] NOP2/Sun domain family, member 2 [HGNC (HUGO)] tRNA (cytosine(34)-C(5))-methyltransferase OS=Homo sapiens GN=NSUN2 PE=1 SV=2 [Swiss-Prot] FLJ20303 protein [HMR_022704.fasta] NOL1/NOP2/Sun domain family 2 protein [Homo sapiens] [nrdb_11152004_Chlamydomonas] Tax_Id=9606 NOL1/NOP2/Sun domain family 2 protein [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta] Tax_Id=9606 NOL1/NOP2/Sun domain family 2 protein [EBI-IPI_human_3.04_03-07-2005_reverse.fasta] FLJ20303 protein [Homo sapiens] [HumanGallus06162005.fasta] tRNA (cytosine-5-)-methyltransferase NSUN2 (NOL1/NOP2/Sun domain family member 2) (tRNA (cytosine-5-)-methyltransferase) (tRNA methyltransferase 4 homolog) (hTrm4) (Substrate of AIM1/Aurora kinase B) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] NOL1/NOP2/Sun domain family, member 2 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Tax_Id=9606 NOL1/NOP2/SUN DOMAIN FAMILY 2 PROTEIN [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=9606 Gene_Symbol=NSUN2 tRNA (cytosine-5-)-methyltransferase NSUN2 [human-ipi-250309-contam.fasta] IPI:IPI00306369.3\|SWISS-PROT:Q08J23\|TREMBL:A8K529;B3KP09;B4DQW2\|ENSEMBL:ENSP00000264670\|REFSEQ:NP_060225\|H-INV:HIT000012070\|VEGA:OTTHUMP00000115518 Tax_Id=9606 Gene_Symbol=NSUN2 tRNA (cytosine-5-)-methyltransferase NSUN2 [ipi.HUMAN.fasta.20090807] [human_BMb_040710_contam.fasta] Tax_Id=9606 Gene_Symbol=NSUN2 tRNA ENSG00000037474 IPI00306369 [drosphohumanreversed.fasta] Tax_Id=9606 Gene_Symbol=NSUN2 tRNA [EBI-IPI_human_3.30_06-28-2007_con_reversed.fasta] tRNA (cytosine-5-)-methyltransferase NSUN2 [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta] tRNA (cytosine-5-)-methyltransferase NSUN2 OS=Homo sapiens GN=NSUN2 PE=1 SV=2 [UniProtHuman070710.fasta] Q08J23;B2RNR4;Q9BVN4;Q9H858;Q9NXD9; RecName: Full=tRNA (cytosine-5-)-methyltransferase NSUN2; AltName: Full=NOL1/NOP2/Sun domain family member 2; AltName: Full=tRNA (cytosine-5-)-methyltransferase; AltName: Full=tRNA methyltransferase 4 homolog; AltName: Full=Substrate of AIM1/Aurora kinase B; [UniProt_Human_2010_06_06-01-2010_reversed.fasta] tRNA (cytosine-5-)-methyltransferase NSUN2 OS=Homo sapiens GN=NSUN2 [011711_HMR.fasta] GeneSymbol=NSUN2 Synonyms=FLJ20303\|MISU\|SAKI\|TRM4 tRNA (cytosine-5-)-methyltransferase NSUN2 isoform 1 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta] tRNA (cytosine(34)-C(5))-methyltransferase OS=Homo sapiens GN=NSUN2 [122011_hum.fasta] IPI:IPI00306369.3\|SWISS-PROT:Q08J23\|TREMBL:A8K529\|ENSEMBL:ENSP00000264670\|REFSEQ:NP_060225\|VEGA:OTTHUMP00000115518 Tax_Id=9606 Gene_Symbol=NSUN2 tRNA (cytosine(34)-C(5))-methyltransferase [ipi.HUMAN.20110912.fasta] tRNA (cytosine(34)-C(5))-methyltransferase GN=NSUN2 [Doctor+uniprot-HUMAN-120911.fasta] Tax_Id=9606 Gene_Symbol=NSUN2 tRNA (cytosine(34)-C(5))-methyltransferase [human-ipi-270911-contam-BSA.fasta]
Organism:	Homo sapiens
Length:	767 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	NONE FOUND
Molecular Function:	NONE FOUND

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGRRSRGRRL QQQQRPEDAE DGAEGGGKRG EAGWEGGYPE IVKENKLFEH YYQELKIVPE  60
   61 GEWGQFMDAL REPLPATLRI TGYKSHAKEI LHCLKNKYFK ELEDLEVDGQ KVEVPQPLSW 120
  121 YPEELAWHTN LSRKILRKSP HLEKFHQFLV SETESGNISR QEAVSMIPPL LLNVRPHHKI 180
  181 LDMCAAPGSK TTQLIEMLHA DMNVPFPEGF VIANDVDNKR CYLLVHQAKR LSSPCIMVVN 240
  241 HDASSIPRLQ IDVDGRKEIL FYDRILCDVP CSGDGTMRKN IDVWKKWTTL NSLQLHGLQL 300
  301 RIATRGAEQL AEGGRMVYST CSLNPIEDEA VIASLLEKSE GALELADVSN ELPGLKWMPG 360
  361 ITQWKVMTKD GQWFTDWDAV PHSRHTQIRP TMFPPKDPEK LQAMHLERCL RILPHHQNTG 420
  421 GFFVAVLVKK SSMPWNKRQP KLQGKSAETR ESTQLSPADL TEGKPTDPSK LESPSFTGTG 480
  481 DTEIAHATED LENNGSKKDG VCGPPPSKKM KLFGFKEDPF VFIPEDDPLF PPIEKFYALD 540
  541 PSFPRMNLLT RTTEGKKRQL YMVSKELRNV LLNNSEKMKV INTGIKVWCR NNSGEEFDCA 600
  601 FRLAQEGIYT LYPFINSRII TVSMEDVKIL LTQENPFFRK LSSETYSQAK DLAKGSIVLK 660
  661 YEPDSANPDA LQCPIVLCGW RGKASIRTFV PKNERLHYLR MMGLEVLGEK KKEGVILTNE 720
  721 SAASTGQPDN DVTEGQRAGE PNSPDAEEAN SPDVTAGCDP AGVHPPR

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..73]	PSI-BLAST	55.154902	The crystal structure of E. coli Fmu binary complex with S-Adenosylmethionine at 2.1 A resolution
2	View Details	[74..505]	PSI-BLAST	59.09691	No description for 2frxA was found.
3	View Details	[506..767]	deduced	N/A	No confident structure predictions are available.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: NSUN2

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: