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Protein Overview: spheroide-PA

General Information:
Name(s) found: spheroide-PA / FBpp0074137 [FlyBase]
Description(s) found:
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  • gi|45549574|ref|NP_573148.2| spheroide [Drosophila melanogaster] [NCBI NR]
  • gi|45447026|gb|AAF48648.2| spheroide [Drosophila melanogaster] [NCBI NR]
  • gi|21428630|gb|AAM49975.1| LP05929p [Drosophila melanogaster] [NCBI NR]
  • The gene spheroide is referred to in FlyBase by the symbol Dmel\spheroide (CG9675, FBgn0030774). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:16594479..16595989. It has the cytological map location 15A1-15A2. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: serine-type endopeptidase activity. There is experimental evidence that it is involved in the biological process</span>: defense response to fungus; innate immune response; defense response to Gram-positive bacterium; positive regulation of Toll signaling pathway. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • (AAF48648) CG9675-PA [DrosMelano7227.FASTAC.txt]
  • CG9675-PA [Drosophila melanogaster]gi|21428630|gb|AAM49975.1| LP05929p [Drosophila melanogaster]gi|45549574|ref|NP_573148.2| CG9675-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=X:complement(16594917..16595445,16595710..16595930); ID=FBpp0074137; name=spheroide-PA; parent=FBgn0030774,FBtr0074363; dbxref=GB_protein:AAF48648.1,FlyBase:FBpp0074137,FlyBase_Annotation_IDs:CG9675-PA,GB_protein:AAF48648.2,REFSEQ:NP_573 [fly-100309-contam.fasta]
  • CG9675-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • LP05929p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=X:complement(16594917..16595445,16595710..16595930); ID=FBpp0074137; name=spheroide-PA; parent=FBgn0030774,FBtr0074363; dbxref=GB_protein:AAF48648.1,FlyBase:FBpp0074137,FlyBase_Annotation_IDs:CG9675-PA,GB_protein:AAF48648.2,REFSEQ:NP_573148,GB_protein:AAF48648; MD5=994412297c32742afac61b2c7dd5cf76; length=249; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=X:complement(16594917..16595445,16595710..16595930); ID=FBpp0074137; name=spheroide-PA; parent=FBgn0030774,FBtr0074363; dbxref=GB_protein:AAF48648.1,FlyBase:FBpp0074137,FlyBase_Annotation_IDs:CG9675-PA,GB_protein:AAF48648.2,REFSEQ:NP_573148,GB_protein:AAF48648; MD5=994412297c32742afac61b2c7dd5cf76; length=249; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • LP05929p OS=Drosophila melanogaster GN=spheroide PE=1 SV=2 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=X:complement(16594917..16595445,16595710..16595930); ID=FBpp0074137; name=spheroide-PA; parent=FBgn0030774,FBtr0074363; dbxref=GB_protein:AAF48648.1,FlyBase:FBpp0074137,FlyBase_Annotation_IDs:CG9675-PA,GB_protein:AAF48648.2,REFSEQ:NP_573148,GB_protein:AAF48648,FlyMine:FBpp0074137,modMine:FBpp0074137; MD5=994412297c32742afac61b2c7dd5cf76; length=249; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • LP05929p OS=Drosophila melanogaster GN=spheroide PE=2 SV=2 [UniProt_D_Melanogaster_07132012_07-13-2012_reversed.fasta]
  • type=protein; loc=X:complement(join(16701677..16701897,16700884..16701412)); ID=FBpp0074137; name=spheroide-PA; parent=FBgn0030774,FBtr0074363; dbxref=GB_protein:AAF48648.1,FlyBase:FBpp0074137,FlyBase_Annotation_IDs:CG9675-PA,GB_protein:AAF48648.2,REFSEQ:NP_573148,GB_protein:AAF48648,FlyMine:FBpp0074137,modMine:FBpp0074137; MD5=994412297c32742afac61b2c7dd5cf76; length=249; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=X:complement(join(16701677..16701897,16700884..16701412)); ID=FBpp0074137; name=spheroide-PA; parent=FBgn0030774,FBtr0074363; dbxref=GB_protein:AAF48648.1,FlyBase:FBpp0074137,FlyBase_Annotation_IDs:CG9675-PA,GB_protein:AAF48648.2,REFSEQ:NP_573148,GB_protein:AAF48648,FlyMine:FBpp0074137,modMine:FBpp0074137; MD5=994412297c32742afac61b2c7dd5cf76; length=249; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Isoform of Q9VXC9, LP05929p OS=Drosophila melanogaster GN=spheroide PE=1 SV=2 [DROME.fasta.20160308]
  • FBpp0074137 type=protein; loc=X:complement(join(16701677..16701897,16700884..16701412)); ID=FBpp0074137; name=spheroide-PA; parent=FBgn0030774,FBtr0074363; dbxref=GB_protein:AAF48648.1,FlyBase:FBpp0074137,FlyBase_Annotation_IDs:CG9675-PA,GB_protein:AAF48648.2,REFSEQ:NP_573148,GB_protein:AAF48648,FlyMine:FBpp0074137,modMine:FBpp0074137; MD5=994412297c32742afac61b2c7dd5cf76; length=249; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=X:complement(join(16701677..16701897,16700884..16701412)); ID=FBpp0074137; name=spheroide-PA; parent=FBgn0030774,FBtr0074363; dbxref=GB_protein:AAF48648.1,FlyBase:FBpp0074137,FlyBase_Annotation_IDs:CG9675-PA,GB_protein:AAF48648.2,REFSEQ:NP_573148,GB_protein:AAF48648,UniProt/TrEMBL:Q9VXC8,FlyMine:FBpp0074137,modMine:FBpp0074137; MD5=994412297c32742afac61b2c7dd5cf76; length=249; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 249 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: innate immune response [IMP]
    proteolysis [IEA]
    positive regulation of Toll signaling pathway [IMP]
    defense response to fungus [IMP]
    defense response to Gram-positive bacterium [IMP]
    Molecular Function: [NOT]serine-type endopeptidase activity [IEA][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMQPRLVILG LIGLTAVGMC HAQGRIMGGE DADATATTFT ASLRVDNAHV CGGSILSQTK  60
   61 ILTTAHCVHR DGKLIDASRL ACRVGSTNQY AGGKIVNVES VAVHPDYYNL NNNLAVITLS 120
  121 SELTYTDRIT AIPLVASGEA LPAEGSEVIV AGWGRTSDGT NSYKIRQISL KVAPEATCLD 180
  181 AYSDHDEQSF CLAHELKEGT CHGDGGGGAI YGNTLIGLTN FVVGACGSRY PDVFVRLSSY 240
  241 ADWIQEQIA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..249] PSI-BLAST 67.221849 Trypsin(ogen)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • peptidase activity
    		•  5.91209560688646 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  5.52773635813967 bayes_pls_golite062009
  • serine hydrolase activity
    		•  5.5105092190926 bayes_pls_golite062009
  • serine-type peptidase activity
    		•  5.49703869306079 bayes_pls_golite062009
  • serine-type endopeptidase activity
    		•  5.39623690248556 bayes_pls_golite062009
  • endopeptidase activity
    		•  5.32070018460528 bayes_pls_golite062009
  • hydrolase activity
    		•  4.40346950809697 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.73928761064649 bayes_pls_golite062009
  • DNA binding
    		•  1.61536775064425 bayes_pls_golite062009
  • catalytic activity
    		•  1.40927913545237 bayes_pls_golite062009
  • binding
    		•  1.30738106455622 bayes_pls_golite062009
  • protein binding
    		•  1.30414885212044 bayes_pls_golite062009
  • receptor activity
    		•  1.2913770619844 bayes_pls_golite062009
  • fucose binding
    		•  1.28001086938735 bayes_pls_golite062009
  • calcium-dependent protein binding
    		•  1.10244132298625 bayes_pls_golite062009
  • heparin binding
    		•  1.0321632468756 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.963459338924623 bayes_pls_golite062009
  • signal transducer activity
    		•  0.963459338924623 bayes_pls_golite062009
  • growth factor activity
    		•  0.848900101748605 bayes_pls_golite062009
  • receptor binding
    		•  0.79054390509229 bayes_pls_golite062009
  • peptide binding
    		•  0.789680301954537 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  0.56945513804111 bayes_pls_golite062009
  • thrombospondin receptor activity
    		•  0.126941350425071 bayes_pls_golite062009
  • polysaccharide binding
    		•  0.0828866805581887 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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