Protein Overview: IRAK2_RAT

General Information:
Name(s) found:	IRAK2_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|81918135\|sp\|Q4QQS0.1\|IRAK2_RAT RecName: Full=Interleukin-1 receptor-associated kinase-like 2; Short=IRAK-2 [NCBI NR] gi\|70794740\|ref\|NP_001020593.1\| interleukin-1 receptor-associated kinase 2 [Rattus norvegicus] [NCBI NR] gi\|67678068\|gb\|AAH98060.1\| Interleukin-1 receptor-associated kinase 2 [Rattus norvegicus] [NCBI NR] ref\|XP_342740.1\| similar to IL-1 receptor-associated kinase 2 [Rattus norvegicus] [NCBI NR] gi\|149036936\|gb\|EDL91554.1\| interleukin-1 receptor-associated kinase 2, isoform CRA_a [Rattus norvegicus] [NCBI NR] Interleukin-1 receptor-associated kinase-like 2 OS=Rattus norvegicus GN=Irak2 PE=2 SV=1 [Swiss-Prot] similar to IL-1 receptor-associated kinase 2 [HMR_022704-rand.fasta] similar to IL-1 receptor-associated kinase 2 [Rattus norvegicus] [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Interleukin-1 receptor-associated kinase 2 [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] Tax_Id=10116 Hypothetical protein [EBI-IPI_rat_3.08_07-12-2005_origrev_con.fasta] Tax_Id=10116 Similar to IL-1 receptor-aSSociated kinaSe 2 [EBI-IPI_rat_3.05_04-04-2005_origrev.fasta] Interleukin-1 receptor-associated kinase-like 2 (IRAK-2) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] interleukin-1 receptor-associated kinase 2 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] interleukin-1 receptor-associated kinase 2, isoform CRA_a [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Interleukin-1 receptor-associated kinase 2 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 SIMILAR TO IL-1 RECEPTOR-ASSOCIATED KINASE 2 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Irak2 Interleukin-1 receptor-associated kinase-like 2 [rat-ipi-250309-contam.fasta] Interleukin-1 receptor-associated kinase-like 2 OS=Rattus norvegicus GN=Irak2 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	624 amino acids
Gene Ontology:
Cellular Component:	cytosol [UNKNOWN] cell surface [UNKNOWN][IEA]
Biological Process:	signal transduction [IEA] negative regulation of NF-kappaB transcription factor activity [UNKNOWN][IEA] [NOT]activation of NF-kappaB-inducing kinase activity [UNKNOWN] response to interleukin-1 [UNKNOWN][IEA] lipopolysaccharide-mediated signaling pathway [UNKNOWN][IEA] [NOT]protein amino acid autophosphorylation [UNKNOWN] regulation of cytokine-mediated signaling pathway [UNKNOWN][IEA] negative regulation of transcription factor activity [UNKNOWN] interleukin-1-mediated signaling pathway [UNKNOWN][IEA] protein amino acid phosphorylation [IEA] positive regulation of NF-kappaB transcription factor activity [UNKNOWN][IEA]
Molecular Function:	ATP binding [IEA] identical protein binding [UNKNOWN] protein binding [UNKNOWN][IEA] protein homodimerization activity [UNKNOWN][IEA] protein heterodimerization activity [UNKNOWN][IEA] protein kinase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MACYIYQLPS WVLDDLCRNI DTLSEWDWMQ FASYVITDLT QLRKIKSMER VQGVSITREL  60
   61 LWWWSMRQAT VQQLVDLLCH LELYRAAQIV LSWKPAPDSL SPLSAFPEAV KPGPVATSGR 120
  121 NLKDDQKKGQ PVKPCSFLSS GTTMAGAQQQ ASCQRPCEED APCSLKTDVP DSLQSKYCST 180
  181 SIPKQEKLLN LPGDRLFWSE ADIVQATEDF DQSHRISEGT FADIYRGQRN GVAFAFKRLR 240
  241 EVTGSSPGSM DRFLQAEMQL CLRCCHPNIL PLLGFCTGRQ FHSLIYPYMA NGSLQDRLWA 300
  301 QGDSDMLSWP QRASICSGLL LAVEHLHSLD IIHSNVKSAN VLLDQHLNPK LAHPVAHPCP 360
  361 TNKKTKYTVM KTHLFQASAA YLPENFIRVG QLTKQVDIFS CGIVLAEVLT GIPAMDKDRS 420
  421 PVYLKDLLLS EIPSNTSSVH SRKTSMGKVV VKEICQKHLE RKAGLLPEAC AETWATAVSV 480
  481 CLRRREASLE EARVSMAGVE EQLRGQLSLP WSRVSEDTGS SSNTPEETDD VDNSSLSVPS 540
  541 SVMVVSCARV SSPPPSMGNG TAQPSTSGRQ EADSSSEACA GPQPPQEATE TSWKIEINEA 600
  601 KRRLMENILL YKEEKLDSVE LFGP

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Protein Overview: IRAK2_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: