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Protein Overview: SHP1

General Information:
Name(s) found: SHP1 / YBL058W [SGD]
Description(s) found:
Found 25 descriptions.
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  • UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 423 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: ascospore formation [IMPLink to PubMed article]
    proteasomal ubiquitin-dependent protein catabolic process [IMPLink to PubMed article]
    glycogen metabolic process [IMPLink to PubMed article]
    telomere maintenance [IMPLink to PubMed article]
    Molecular Function: protein phosphatase type 1 regulator activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEIPDETIQ QFMALTNVSH NIAVQYLSEF GDLNEALNSY YASQTDDQKD RREEAHWNRQ  60
   61 QEKALKQEAF STNSSNKAIN TEHVGGLCPK PGSSQGSNEY LKRKGSTSPE PTKGSSRSGS 120
  121 GNNSRFMSFS DMVRGQADDD DEDQPRNTFA GGETSGLEVT DPSDPNSLLK DLLEKARRGG 180
  181 QMGAENGFRD DEDHEMGANR FTGRGFRLGS TIDAADEVVE DNTSQSQRRP EKVTREITFW 240
  241 KEGFQVADGP LYRYDDPANS FYLSELNQGR APLKLLDVQF GQEVEVNVYK KLDESYKAPT 300
  301 RKLGGFSGQG QRLGSPIPGE SSPAEVPKNE TPAAQEQPMP DNEPKQGDTS IQIRYANGKR 360
  361 EVLHCNSTDT VKFLYEHVTS NANTDPSRNF TLNYAFPIKP ISNDETTLKD ADLLNSVVVQ 420
  421 RWA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CDC48 NPL4 SHP1
    View Details Krogan NJ, et al. (2006) BFA1 CDC48 DOA1 FBP1 MRM1 NDT80 NPL4 OTU1 RDS2 SHP1 TEM1 TUP1 UBX4 UBX5 UBX7 UFD1 UFD2 YDR049W YGL108C YJR098C YNL155W YOR342C
    View Details Gavin AC, et al. (2006) CDC48 NPL4 SHP1 UFD1 YDR049W
    View Details Gavin AC, et al. (2002) BNI1 CDC48 DOA1 MRPS28 NPL4 PDC1 RAI1 REG1 RPA135 RPA190 RPO31 SHP1 UFD1 YDR049W
    View Details Ho Y, et al. (2002) DSK2 GND1 HHF1, HHF2 HMF1 HTB2 HTZ1 NPL4 RAD16 RAD23 RAD7 RNQ1 SHP1 TDP1 TMA29 TSA2 TSL1 UBI4 UFD2 YDR049W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen NUP1 SHP1 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SHP1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..121] deduced N/A No confident structure predictions are available.
    2 View Details [122..340] MSA 1.067995 View MSA. No confident structure predictions are available.
    3 View Details [341..423] PSI-BLAST 77.071898 p47
    4 View Details [313..423] PSI-BLAST 34.221849 Crystal structure of AAA ATPase p97/VCP ND1 in complex with p47 C

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • ubiquitin binding
    		•  3.08647023955532 bayes_pls_golite062009
  • small conjugating protein binding
    		•  2.81420954636829 bayes_pls_golite062009
  • binding
    		•  2.2560795328149 bayes_pls_golite062009
  • protein binding
    		•  1.0980671422772 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.603841502857006 bayes_pls_golite062009
  • hydrolase activity
    		•  0.356947688028291 bayes_pls_golite062009
  • catalytic activity
    		•  0.25774924710417 bayes_pls_golite062009
  • DNA binding
    		•  0.227398235412559 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.194425568150525 bayes_pls_golite062009
  • peptidase activity
    		•  0.0141774634963068 bayes_pls_golite062009
    3 No functions predicted.
    4
    Term Confidence Notes
  • binding
    		•  2.63877637096497 bayes_pls_golite062009
  • protein binding
    		•  1.89134588490127 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  1.83465130904364 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  1.16468510691469 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  0.919595189902044 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.383121378043805 bayes_pls_golite062009
  • hydrolase activity
    		•  0.247201449341942 bayes_pls_golite062009
  • DNA binding
    		•  0.0840213088061073 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.0485636215870291 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.00343080662821671 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle