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Protein Overview: SLX5

General Information:
Name(s) found: SLX5 / YDL013W [SGD]
Description(s) found:
Found 35 descriptions.
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  • Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex, stimulated by SUMO-modified substrates; contains a RING domain and two SIMs (SUMO-interacting motifs); forms SUMO-dependent nuclear foci, including DNA repair centers [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 619 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: protein sumoylation [IGILink to PubMed article][IMPLink to PubMed article]
    telomere maintenance [IMPLink to PubMed article]
    response to DNA damage stimulus [IGILink to PubMed articleLink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHSDTNGRTK SNNSPSDNNP NETVILIDSD KEEDASIREA NLPVRLYPDR RVGRRRDALN  60
   61 RFVRSDSRSR NSQRTHITAS SERPDFQANN DDITIIREVG RFFGDDGPID PSAHYVDLDQ 120
  121 EPGSETLETP RTIQVDNTNG YLNDNGNNNE SDDGLTIVEE RTTRPRVTLN LPGGERLEVT 180
  181 ATTTDIPIRR SFEFQEDLGA SRRQLLRRSA TRARNLFVDR SDENDEDWTD DTHNLPEAIQ 240
  241 RARRESRMRM SRRIAERQRR VQQQRVSSDE NISTSIRLQS IRERIQSYTP DIRSAFHRAE 300
  301 SLHEFRSILQ NVAPITLQEC EEELMALFTE FRNQLLQNWA IDRVRNTQEE ALRLHREALE 360
  361 RQERTAGRVF HRGTLRESIT NYLNFNGEDG FLSRLWSGPA LSDADEERHT QNIIDMIQER 420
  421 EERERDVVMK NLMNKTRAQQ EEFEARAASL PEGYSASFDT TPKMKLDITK NGKEETIIVT 480
  481 DDDLAKTLED IPVCCLCGAE LGVGIPDDFT GISQKDRGVS FEGLVSKYKF HCPYQTLARP 540
  541 SMLDRDLSKR TFIASCGHAF CGRCFARIDN AKKKSKMPKK KLAQLKGSAH PDNYGPKLCP 600
  601 ADSCKKLIRS RGRLKEVYF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) GSG1 POL4 RPN1 RPN10 RPN11 RPN12 RPN13 RPN2 RPN5 RPN6 RPN8 RPN9 RPT1 RPT2 RPT3 RPT4 RPT5 RPT6 SEM1 SLX5 SPG5 SWA2 UBP6
    View Details Krogan NJ, et al. (2006) ABF2 ARG82 CKI1 CMR1 HHF1, HHF2 HTA1 HTA2 HTB1 HTB2 NUP188 PPH3 PSY2 PSY4 RRD1 SLX5 SLX8 SPT5 STP1 TOP2
    View Details Ho Y, et al. (2002) PTP2 SLX5 SSK1 SSK2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run PAN1 No Comments Toshima J, et al (2006)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SPP382 SLX5 2 Hazbun TR, et al. (2003)
    View Screen NSE5 SLX5 2 Hazbun TR, et al. (2003)
    View Screen YOR287C SLX5 2 Hazbun TR, et al. (2003)
    View Screen SAS3 SLX5 2 Unpublished Fields Lab Data
    View Screen SMT3 SLX5 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..619] deduced N/A No confident structure predictions are available.
    2 View Details [129..224] deduced N/A No confident structure predictions are available.
    3 View Details [225..400] deduced N/A No confident structure predictions are available.
    4 View Details [401..619] FFAS03 1.21 Effector domain of rabphilin-3a

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • small conjugating protein ligase activity
    		•  6.54419701634876 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  5.81081610285635 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  4.98431511196461 bayes_pls_golite062009
  • binding
    		•  2.64299129598715 bayes_pls_golite062009
  • histone binding
    		•  2.18177552065219 bayes_pls_golite062009
  • ligase activity
    		•  1.77976870053311 bayes_pls_golite062009
  • protein binding
    		•  1.22943142958169 bayes_pls_golite062009
  • DNA binding
    		•  1.19418339248022 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.16305426959673 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.03976333752272 bayes_pls_golite062009
  • chromatin binding
    		•  0.880691867408093 bayes_pls_golite062009
  • methylated histone residue binding
    		•  0.635303636820801 bayes_pls_golite062009
  • protein kinase activity
    		•  0.408714103048697 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.152196493675947 bayes_pls_golite062009
  • transcription factor activity
    		•  0.124593950007804 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  0.108887977080526 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  0.108887977080526 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.0912529186589195 bayes_pls_golite062009
  • kinase activity
    		•  0.00873885939655655 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle