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Protein Overview: SIR2

General Information:
Name(s) found: SIR2 / YDL042C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Conserved NAD+ dependent histone deacetylase of the Sirtuin family involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres, and the rDNA locus; negatively regulates initiation of DNA replication [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 562 amino acids

    Gene Ontology:
    Cellular Component: nuclear telomeric heterochromatin [IDALink to PubMed article]
    RENT complex [IDALink to PubMed article]
    nucleolus [IDALink to PubMed article]
    chromatin silencing complex [IDALink to PubMed article]
    nuclear telomere cap complex [IDALink to PubMed article]
    Biological Process: chromatin silencing at rDNA [IMPLink to PubMed article]
    loss of chromatin silencing involved in replicative cell aging [TASLink to PubMed article]
    chromatin assembly or disassembly [IDALink to PubMed article]
    negative regulation of DNA replication [IMPLink to PubMed article]
    double-strand break repair via nonhomologous end joining [IDALink to PubMed article]
    chromatin silencing at silent mating-type cassette [IMPLink to PubMed article]
    replicative cell aging [IMPLink to PubMed article]
    chromatin silencing at telomere [IMPLink to PubMed article][IPILink to PubMed article]
    chronological cell aging [IMPLink to PubMed article]
    Molecular Function: NAD-dependent histone deacetylase activity (H3-K9 specific) [IDALink to PubMed article][ISSLink to PubMed article]
    NAD-dependent histone deacetylase activity (H4-K16 specific) [IDALink to PubMed article][ISSLink to PubMed article]
    NAD-dependent histone deacetylase activity (H3-K14 specific) [IDALink to PubMed article][ISSLink to PubMed article]
    NAD-dependent histone deacetylase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTIPHMKYAV SKTSENKVSN TVSPTQDKDA IRKQPDDIIN NDEPSHKKIK VAQPDSLRET  60
   61 NTTDPLGHTK AALGEVASME LKPTNDMDPL AVSAASVVSM SNDVLKPETP KGPIIISKNP 120
  121 SNGIFYGPSF TKRESLNARM FLKYYGAHKF LDTYLPEDLN SLYIYYLIKL LGFEVKDQAL 180
  181 IGTINSIVHI NSQERVQDLG SAISVTNVED PLAKKQTVRL IKDLQRAINK VLCTRLRLSN 240
  241 FFTIDHFIQK LHTARKILVL TGAGVSTSLG IPDFRSSEGF YSKIKHLGLD DPQDVFNYNI 300
  301 FMHDPSVFYN IANMVLPPEK IYSPLHSFIK MLQMKGKLLR NYTQNIDNLE SYAGISTDKL 360
  361 VQCHGSFATA TCVTCHWNLP GERIFNKIRN LELPLCPYCY KKRREYFPEG YNNKVGVAAS 420
  421 QGSMSERPPY ILNSYGVLKP DITFFGEALP NKFHKSIRED ILECDLLICI GTSLKVAPVS 480
  481 EIVNMVPSHV PQVLINRDPV KHAEFDLSLL GYCDDIAAMV AQKCGWTIPH KKWNDLKNKN 540
  541 FKCQEKDKGV YVVTSDEHPK TL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) NET1 SIR2 SIR4
    View Details Krogan NJ, et al. (2006) GPG1 SIR2 SIR3 SIR4 YLR278C
    View Details Gavin AC, et al. (2002) ADH1 BGL2 CDC14 HSP42 NET1 SIR2 SIR4 TDH3 YEF3
    View Details Ho Y, et al. (2002) BLM10 SEC53 SIR2 SIR3 SIR4 SRP1 YFL006W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run ASF1 3829 - low filter Green EM, et al (2005)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SPO21 SIR2 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SIR2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..191] deduced N/A No confident structure predictions are available.
    2 View Details [192..273]
    [317..366]
    [450..562]    		 PSI-BLAST 480.38764 Sirt2 histone deacetylase
    3 View Details [274..316]
    [367..449]    		 PSI-BLAST 480.38764 Sirt2 histone deacetylase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • protein deacetylase activity
    		•  11.8771442637949 bayes_pls_golite062009
  • histone deacetylase activity
    		•  11.7308825525122 bayes_pls_golite062009
  • deacetylase activity
    		•  10.8368006972109 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
    		•  8.53375308475286 bayes_pls_golite062009
  • NAD-dependent protein deacetylase activity
    		•  8.13038616303736 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity
    		•  8.13038616303736 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity (H3-K9 specific)
    		•  7.45234027270448 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity (H3-K14 specific)
    		•  7.45234027270448 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  7.0185004322765 bayes_pls_golite062009
  • histone deacetylase activity (H3-K14 specific)
    		•  6.02509672218091 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity (H4-K16 specific)
    		•  5.11288441003953 bayes_pls_golite062009
  • tubulin deacetylase activity
    		•  4.98963898611597 bayes_pls_golite062009
  • histone deacetylase activity (H3-K9 specific)
    		•  4.84457718476539 bayes_pls_golite062009
  • NAD+ ADP-ribosyltransferase activity
    		•  4.62921662347995 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.9155913558118 bayes_pls_golite062009
  • DNA binding
    		•  2.43141001866996 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.41433477472968 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.24657784428979 bayes_pls_golite062009
  • binding
    		•  2.06552694538163 bayes_pls_golite062009
  • NAD-independent histone deacetylase activity
    		•  2.03444106183496 bayes_pls_golite062009
  • histone binding
    		•  1.71445510915336 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.64212790017753 bayes_pls_golite062009
  • protein binding
    		•  1.52593340148652 bayes_pls_golite062009
  • nucleosome binding
    		•  1.5125174755597 bayes_pls_golite062009
  • hydrolase activity
    		•  1.43067365161346 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  1.40719303660557 bayes_pls_golite062009
  • transcription factor activity
    		•  1.30143289828088 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  1.26370407179255 bayes_pls_golite062009
  • transcription factor binding
    		•  1.14766678956419 bayes_pls_golite062009
  • NAD(P)+-protein-arginine ADP-ribosyltransferase activity
    		•  0.963519974868694 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  0.74741958699764 bayes_pls_golite062009
  • catalytic activity
    		•  0.739210399081789 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.56434127203174 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.54005617175343 bayes_pls_golite062009
  • transferase activity
    		•  0.483523935618287 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle