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Protein Overview: TCP1

General Information:
Name(s) found: TCP1 / YDR212W [SGD]
Description(s) found:
Found 32 descriptions.
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  • Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 559 amino acids

    Gene Ontology:
    Cellular Component: chaperonin-containing T-complex [IPILink to PubMed article][TASLink to PubMed article]
    cytoskeleton [TASLink to PubMed article]
    cytoplasm [TASLink to PubMed article]
    Biological Process: cytoskeleton organization [TASLink to PubMed article]
    protein folding [TASLink to PubMed article]
    Molecular Function: unfolded protein binding [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQLFNNSRS DTLFLGGEKI SGDDIRNQNV LATMAVANVV KSSLGPVGLD KMLVDDIGDF  60
   61 TVTNDGATIL SLLDVQHPAG KILVELAQQQ DREIGDGTTS VVIIASELLK RANELVKNKI 120
  121 HPTTIITGFR VALREAIRFI NEVLSTSVDT LGKETLINIA KTSMSSKIIG ADSDFFSNMV 180
  181 VDALLAVKTQ NSKGEIKYPV KAVNVLKAHG KSATESLLVP GYALNCTVAS QAMPKRIAGG 240
  241 NVKIACLDLN LQKARMAMGV QINIDDPEQL EQIRKREAGI VLERVKKIID AGAQVVLTTK 300
  301 GIDDLCLKEF VEAKIMGVRR CKKEDLRRIA RATGATLVSS MSNLEGEETF ESSYLGLCDE 360
  361 VVQAKFSDDE CILIKGTSKH SSSSIILRGA NDYSLDEMER SLHDSLSVVK RTLESGNVVP 420
  421 GGGCVEAALN IYLDNFATTV GSREQLAIAE FAAALLIIPK TLAVNAAKDS SELVAKLRSY 480
  481 HAASQMAKPE DVKRRSYRNY GLDLIRGKIV DEIHAGVLEP TISKVKSLKS ALEACVAILR 540
  541 IDTMITVDPE PPKEDPHDH

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CCT2 CCT3 CCT5 CCT6 TCP1
    View Details (MIPS) Mewes HW, et al. (2004) CCT2 CCT3 CCT4 CCT5 CCT6 CCT7 CCT8 TCP1
    View Details Krogan NJ, et al. (2006) ARC15 ASR1 CAJ1 CDC7 CRN1 INP52 IRC22 MSK1 PNO1 PST2 RAD34 SAC6 SAR1 SLM1 TCP1 TED1 YPP1
    View Details Ho Y, et al. (2002) AHA1 AIM46 ARC35 ARP2 BCY1 BRX1 BTN2 CAF4 CCT2 CCT3 CCT5 CCT6 CDC20 CDC28 CDC55 CFT1 CLU1 COP1 COR1 CTR1 DHH1 DIA4 DUN1 EAP1 EGD1 ENT2 FET4 GAL7 GAL83 GCD11 GCN1 GDT1 GPA1 GSY1 HGH1 HXT7 IDH1 IDH2 IME2 KAP95 LEM3 MAD3 MDH1 MEH1 MET10 MKK2 NAP1 NMD3 NMD5 NPA3 OSH7 PFS2 PPH21 PPH22 PPH3 PRB1 PRP19 PSY2 PSY4 PWP1 QCR2 RAD24 RAD28 RFC2 RFC3 RFC5 RIM15 RNQ1 RPN1 RPN7 RPT3 SEC27 SEC28 SEC53 SIP2 SNF1 SNF4 SOD1 SOF1 SRP54 STE12 STE4 STI1 TAF5 TCP1 TIF1, TIF2 TPD3 TPK1 TPK2 TPK3 VPS13 WTM1 WTM2 YBL029W YCR076C YER160C YHR033W YJU2 YLR326W YLR413W YNK1
    View Details Qiu et al. (2008) CCT2 CCT3 CCT4 CCT5 CCT6 CCT7 CCT8 SSA2 TCP1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run TOR1 No Comments Reinke A, et al. (2004)
    View Run LST8 No Comments Reinke A, et al. (2004)
    View Run TOR2 No Comments Reinke A, et al. (2004)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi1 with gst from october 2005 McCusker D, et al (2007)
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run MLP2 #01 Alpha factor Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #05 Alpha Factor Prep2-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #07 Alpha Factor Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen TCP1 FRT1 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..110]
    [144..420]
    [515..559]    		 PSI-BLAST 1008.9897 Thermosome, E domain; Thermosome, A-domain; Thermosome, I domain
    2 View Details [111..143]
    [421..514]    		 PSI-BLAST 1008.9897 Thermosome, E domain; Thermosome, A-domain; Thermosome, I domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • unfolded protein binding
    		•  7.60116801069598 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  3.6934849790316 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  3.40373598585301 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  3.28982639907979 bayes_pls_golite062009
  • binding
    		•  2.07154556649829 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.67284737458957 bayes_pls_golite062009
  • DNA binding
    		•  1.60256620441721 bayes_pls_golite062009
  • transporter activity
    		•  1.27879339110564 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.08697283907212 bayes_pls_golite062009
  • chaperone binding
    		•  0.91200031047441 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.828920415160435 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  0.787685249362834 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.75018875403424 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.69634667457441 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.682843768728088 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.680378643689288 bayes_pls_golite062009
  • protein binding
    		•  0.634982583867058 bayes_pls_golite062009
  • ATPase activity
    		•  0.584574936611857 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.573106450426516 bayes_pls_golite062009
  • catalytic activity
    		•  0.424959044318554 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.280310103153739 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.275534581026027 bayes_pls_golite062009
  • hydrogen-exporting ATPase activity, phosphorylative mechanism
    		•  0.26275673855778 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.252704226951294 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.243984617084631 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  0.205808843369749 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  0.202279803135899 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  0.20198255686005 bayes_pls_golite062009
  • transferase activity
    		•  0.18639662517366 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.16424934648837 bayes_pls_golite062009
  • kinase activity
    		•  0.0871496920547826 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.0778814959589007 bayes_pls_golite062009
  • hydrolase activity
    		•  0.0491351110520448 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle