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Protein Overview: RAD23

General Information:
Name(s) found: RAD23 / YEL037C [SGD]
Description(s) found:
Found 29 descriptions.
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  • Protein with ubiquitin-like N terminus, subunit of Nuclear Excision Repair Factor 2 (NEF2) with Rad4p that recognizes and binds damaged DNA; enhances protein deglycosylation activity of Png1p; homolog of human HR23A and HR23B [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 398 amino acids

    Gene Ontology:
    Cellular Component: nucleotide-excision repair factor 2 complex [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    repairosome [IDALink to PubMed article]
    proteasome complex [IMPLink to PubMed article][IPILink to PubMed article]
    Biological Process: nucleotide-excision repair, DNA damage recognition [TASLink to PubMed article]
    negative regulation of protein catabolic process [TASLink to PubMed article]
    ER-associated protein catabolic process [IMPLink to PubMed article]
    Molecular Function: damaged DNA binding [IDALink to PubMed articleLink to PubMed article]
    protein binding, bridging [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVSLTFKNFK KEKVPLDLEP SNTILETKTK LAQSISCEES QIKLIYSGKV LQDSKTVSEC  60
   61 GLKDGDQVVF MVSQKKSTKT KVTEPPIAPE SATTPGRENS TEASPSTDAS AAPAATAPEG 120
  121 SQPQEEQTAT TERTESASTP GFVVGTERNE TIERIMEMGY QREEVERALR AAFNNPDRAV 180
  181 EYLLMGIPEN LRQPEPQQQT AAAAEQPSTA ATTAEQPAED DLFAQAAQGG NASSGALGTT 240
  241 GGATDAAQGG PPGSIGLTVE DLLSLRQVVS GNPEALAPLL ENISARYPQL REHIMANPEV 300
  301 FVSMLLEAVG DNMQDVMEGA DDMVEGEDIE VTGEAAAAGL GQGEGEGSFQ VDYTPEDDQA 360
  361 ISRLCELGFE RDLVIQVYFA CDKNEEAAAN ILFSDHAD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) PNG1 RAD23 RAD4
    View Details (MIPS) Mewes HW, et al. (2004) RAD23 RAD4
    View Details Krogan NJ, et al. (2006) PNG1 RAD23
    View Details Gavin AC, et al. (2002) DNA2 ECM29 KAP95 MEC1 MPH1 MRPS28 MSH2 MSH6 PGK1 RAD23 RAD34 RAD4 RAD52 RFA1 RFA2 RPN10 RPN12 RPN3 RPN6 RPN8 RPN9 RPT2 RPT3 RPT6 SRO7 SSL1 TFA1 TFB1 TFB4
    View Details Ho Y, et al. (2002) DSK2 HMF1 NPL4 RAD23 SHP1 TSL1 UBI4 UFD2 YCR001W YDR049W
    View Details Qiu et al. (2008) ABF1 RAD14 RAD16 RAD23 RAD4 RAD7

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen RAD23 UBI4 2 Unpublished Fields Lab Data
    View Screen RAD4 RAD23 2 Uetz P, et al. (2000)
    View Screen RPN1 RAD23 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data RAD23 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..108] PSI-BLAST 49.519517 Ubiquitin
    2 View Details [109..218] PSI-BLAST 102.09691 DNA repair protein Hhr23a
    3 View Details [219..345] MSA 2.061993 View MSA. No confident structure predictions are available.
    4 View Details [346..398] PSI-BLAST 74.39794 DNA repair protein Hhr23a

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  3.35791544110308 bayes_pls_golite062009
  • hydrolase activity
    		•  2.77871378503369 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  2.06714283858345 bayes_pls_golite062009
  • protein binding
    		•  1.76858817153382 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  1.48147454986498 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.42747465816672 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.32707653701567 bayes_pls_golite062009
  • DNA binding
    		•  1.22622447288034 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  1.0818414663245 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.570143717979967 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.366426020658587 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  0.364036714119806 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.249928925871521 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle