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Protein Overview: SEC4

General Information:
Name(s) found: SEC4 / YFL005W [SGD]
Description(s) found:
Found 32 descriptions.
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  • Rab family GTPase essential for vesicle-mediated exocytic secretion and autophagy; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 215 amino acids

    Gene Ontology:
    Cellular Component: incipient cellular bud site [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    vesicle [IDALink to PubMed article]
    transport vesicle [TASLink to PubMed article]
    mitochondrial outer membrane [IDALink to PubMed article]
    actin cap [IDALink to PubMed article]
    Biological Process: vesicle fusion [TASLink to PubMed article]
    bipolar cellular bud site selection [IMPLink to PubMed article]
    small GTPase mediated signal transduction [TASLink to PubMed article]
    Golgi to plasma membrane transport [TASLink to PubMed article]
    ascospore-type prospore formation [IMPLink to PubMed article]
    cytokinesis [IMPLink to PubMed article]
    exocytosis [IDALink to PubMed article]
    membrane addition at site of cytokinesis [IEPLink to PubMed article][IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: GTPase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGLRTVSAS SGNGKSYDSI MKILLIGDSG VGKSCLLVRF VEDKFNPSFI TTIGIDFKIK  60
   61 TVDINGKKVK LQLWDTAGQE RFRTITTAYY RGAMGIILVY DVTDERTFTN IKQWFKTVNE 120
  121 HANDEAQLLL VGNKSDMETR VVTADQGEAL AKELGIPFIE SSAKNDDNVN EIFFTLAKLI 180
  181 QEKIDSNKLV GVGNGKEGNI SINSGSGNSS KSNCC

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) DSS4 SEC4 YPT1
    View Details Ho Y, et al. (2002) AFG2 ALB1 ARX1 DSS4 FAA4 GDI1 MRS6 NOG1 NOP7 SEC4 STE11 VPS21 YPT1 YPT10 YPT31 YPT32 YPT52 YPT6 YPT7
    View Details Qiu et al. (2008) CHS6 MSB3 RHO1 SAR1 SEC4 YOS1 YPT31 YPT32

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MIA40 No Comments Hazbun TR, et al. (2003)
    View Run VAM3 Sample: HX11 - both fusion and trans-SNARE complex formation take place. Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX14 - mixture in detergent (control). Hao Xu, et al. (2010)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SEC4 PAR32 2 Unpublished Fields Lab Data
    View Screen SEC4 MRS6 2 Unpublished Fields Lab Data
    View Screen SEC4 PRM3 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..215] PSI-BLAST 968.274545 Rab-related protein Sec4

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • GTPase activity
    		•  4.52394549632777 bayes_pls_golite062009
  • microtubule motor activity
    		•  4.51968578934603 bayes_pls_golite062009
  • motor activity
    		•  4.04927796049806 bayes_pls_golite062009
  • hydrolase activity
    		•  3.63069754092699 bayes_pls_golite062009
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•  3.57926427233638 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  3.4837867129694 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  3.35436118751376 bayes_pls_golite062009
  • actin binding
    		•  3.33639699088484 bayes_pls_golite062009
  • microfilament motor activity
    		•  3.17800963620802 bayes_pls_golite062009
  • transporter activity
    		•  3.10463051760206 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  3.08390071341252 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  3.070470376968 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.95886887664984 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.95079405147356 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.87427509025394 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.85499564954033 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.85178667290149 bayes_pls_golite062009
  • amine-transporting ATPase activity
    		•  2.69529191205818 bayes_pls_golite062009
  • organic acid transmembrane transporter activity
    		•  2.67957846350199 bayes_pls_golite062009
  • carboxylic acid transmembrane transporter activity
    		•  2.67815672695824 bayes_pls_golite062009
  • tubulin binding
    		•  2.67743463093593 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  2.61775212528604 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  2.61467977505707 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  2.61311581579476 bayes_pls_golite062009
  • microtubule binding
    		•  2.59155206524122 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  2.57552435627908 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  2.57107347424517 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  2.57054427875021 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.51683451033161 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  2.50494515048649 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  2.43862163407966 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.4101693596493 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  2.40292717311506 bayes_pls_golite062009
  • ATPase activity
    		•  2.39535714892224 bayes_pls_golite062009
  • amine transmembrane transporter activity
    		•  2.29486577878686 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  2.26365379756656 bayes_pls_golite062009
  • actin filament binding
    		•  2.24723363507804 bayes_pls_golite062009
  • anion transmembrane-transporting ATPase activity
    		•  2.12727614888121 bayes_pls_golite062009
  • DNA binding
    		•  2.12258000781149 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.09345198747025 bayes_pls_golite062009
  • structural molecule activity
    		•  2.08211451183607 bayes_pls_golite062009
  • proton-transporting ATPase activity, rotational mechanism
    		•  1.95782378818812 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.91091452720653 bayes_pls_golite062009
  • guanyl nucleotide binding
    		•  1.89320355239381 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  1.88721318481223 bayes_pls_golite062009
  • GTP binding
    		•  1.87900088157196 bayes_pls_golite062009
    		• 1.86855842486607 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.85943679361938 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.85937484083653 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.8521191028835 bayes_pls_golite062009
  • nucleotide binding
    		•  1.84603132945448 bayes_pls_golite062009
  • kinase activity
    		•  1.80889641165674 bayes_pls_golite062009
  • structural constituent of muscle
    		•  1.75982319871463 bayes_pls_golite062009
  • protein transporter activity
    		•  1.71214667007262 bayes_pls_golite062009
  • helicase activity
    		•  1.70242731830224 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  1.63949223587737 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.60386625568858 bayes_pls_golite062009
  • amino acid transmembrane transporter activity
    		•  1.59627719545436 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  1.58971273330352 bayes_pls_golite062009
  • actin-dependent ATPase activity
    		•  1.58897222423517 bayes_pls_golite062009
  • ATP binding
    		•  1.5859264197035 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.55520429131224 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.53158018507951 bayes_pls_golite062009
  • plus-end-directed microtubule motor activity
    		•  1.38366133153678 bayes_pls_golite062009
  • apolipoprotein receptor activity
    		•  1.31055516357904 bayes_pls_golite062009
  • syntaxin-13 binding
    		•  1.31055516357904 bayes_pls_golite062009
  • apolipoprotein A-I binding
    		•  1.31055516357904 bayes_pls_golite062009
  • apolipoprotein A-I receptor activity
    		•  1.31055516357904 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of ions
    		•  1.23799860254751 bayes_pls_golite062009
  • protein binding
    		•  1.22129154759482 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  1.2155186842031 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.14475274823167 bayes_pls_golite062009
  • peptidase activity
    		•  1.12876670227791 bayes_pls_golite062009
  • protein kinase activity
    		•  1.12864835254143 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • cation channel activity
    		•  0.997064416395892 bayes_pls_golite062009
  • GMP binding
    		•  0.975301479415235 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  0.971476020912368 bayes_pls_golite062009
  • DNA polymerase activity
    		•  0.928091843881235 bayes_pls_golite062009
  • peptide-transporting ATPase activity
    		•  0.911425383309011 bayes_pls_golite062009
  • transcription activator activity
    		•  0.889929694023098 bayes_pls_golite062009
  • transcription factor activity
    		•  0.887108427603557 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  0.876296121718575 bayes_pls_golite062009
  • transferase activity
    		•  0.871779313294914 bayes_pls_golite062009
  • transferase activity, transferring glycosyl groups
    		•  0.813093882989183 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.782430219754236 bayes_pls_golite062009
  • di-, tri-valent inorganic cation transmembrane transporter activity
    		•  0.767424210804186 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  0.765442336337003 bayes_pls_golite062009
  • peptide transporter activity
    		•  0.73541731084591 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.72881469450553 bayes_pls_golite062009
  • ribonuclease activity
    		•  0.712344060953362 bayes_pls_golite062009
  • inorganic anion transmembrane transporter activity
    		•  0.69784475011795 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  0.688632087597536 bayes_pls_golite062009
  • signal transducer activity
    		•  0.683309012097319 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.683309012097319 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.661834961742057 bayes_pls_golite062009
  • protein-DNA loading ATPase activity
    		•  0.650964453464311 bayes_pls_golite062009
  • steroid hormone receptor binding
    		•  0.647625526012423 bayes_pls_golite062009
  • calcium channel activity
    		•  0.636216614902039 bayes_pls_golite062009
  • receptor activity
    		•  0.633514002718998 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  0.63002958837536 bayes_pls_golite062009
  • cell surface binding
    		•  0.618263399939881 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.6071273686445 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.5886142102548 bayes_pls_golite062009
  • nucleotide kinase activity
    		•  0.56979593127581 bayes_pls_golite062009
  • beta-catenin binding
    		•  0.567325521781475 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  0.562664200036023 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  0.559798751382976 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.543891899378373 bayes_pls_golite062009
  • DNA clamp loader activity
    		•  0.543512707823441 bayes_pls_golite062009
  • DNA strand annealing activity
    		•  0.495691434532349 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  0.46552249844591 bayes_pls_golite062009
  • branched-chain aliphatic amino acid transmembrane transporter activity
    		•  0.442220326523999 bayes_pls_golite062009
  • anion transmembrane transporter activity
    		•  0.43332053110728 bayes_pls_golite062009
  • signal sequence binding
    		•  0.42240724331108 bayes_pls_golite062009
  • drug transmembrane transporter activity
    		•  0.38711726712063 bayes_pls_golite062009
  • hormone receptor binding
    		•  0.351501100511918 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.345873656782869 bayes_pls_golite062009
  • potassium channel activity
    		•  0.329290830676079 bayes_pls_golite062009
  • gated channel activity
    		•  0.299411774392227 bayes_pls_golite062009
  • translation regulator activity
    		•  0.29096092258568 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.274994961137851 bayes_pls_golite062009
  • myosin binding
    		•  0.274885859454447 bayes_pls_golite062009
  • transition metal ion transmembrane transporter activity
    		•  0.248918847596573 bayes_pls_golite062009
  • nuclear hormone receptor binding
    		•  0.246160342138071 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.243902356228423 bayes_pls_golite062009
  • signal recognition particle binding
    		•  0.20866768220789 bayes_pls_golite062009
  • RNA helicase activity
    		•  0.18426050934025 bayes_pls_golite062009
  • ion channel activity
    		•  0.154779598791225 bayes_pls_golite062009
  • amino acid-transporting ATPase activity
    		•  0.147644650870465 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  0.14606996093053 bayes_pls_golite062009
  • channel activity
    		•  0.134817721656507 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.134817721656507 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  0.13050483816765 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.126911677161968 bayes_pls_golite062009
  • nucleobase, nucleoside, nucleotide kinase activity
    		•  0.12351419478929 bayes_pls_golite062009
  • minus-end directed microfilament motor activity
    		•  0.103268955687259 bayes_pls_golite062009
  • GBD domain binding
    		•  0.0922383758186687 bayes_pls_golite062009
  • voltage-gated calcium channel activity
    		•  0.0789800146503108 bayes_pls_golite062009
  • RNA binding
    		•  0.0693163519626152 bayes_pls_golite062009
  • cation-transporting ATPase activity
    		•  0.0536898657672154 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.0111338193708552 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven protein transmembrane transporter activity
    		•  0.00571427458217011 bayes_pls_golite062009
  • macromolecule transmembrane transporter activity
    		•  0.00571427458217011 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle