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Protein Overview: CLF1

General Information:
Name(s) found: CLF1 / YLR117C [SGD]
Description(s) found:
Found 30 descriptions.
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  • Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 687 amino acids

    Gene Ontology:
    Cellular Component: chromatin [IDALink to PubMed article]
    Biological Process: DNA replication [IMPLink to PubMed article]
    cell cycle [TASLink to PubMed article]
    cis assembly of pre-catalytic spliceosome [IMPLink to PubMed article]
    nuclear mRNA splicing, via spliceosome [IMPLink to PubMed article]
    Molecular Function: protein binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDTLEPTAVD THVSAEQILR DVYKKGQKAR GSTNIDILDL EELREYQRRK RTEYEGYLKR  60
   61 NRLDMGQWIR YAQFEIEQHD MRRARSIFER ALLVDSSFIP LWIRYIDAEL KVKCINHARN 120
  121 LMNRAISTLP RVDKLWYKYL IVEESLNNVE IVRSLYTKWC SLEPGVNAWN SFVDFEIRQK 180
  181 NWNGVREIYS KYVMAHPQMQ TWLKWVRFEN RHGNTEFTRS VYSLAIDTVA NLQNLQIWSD 240
  241 MEVAKLVNSF AHWEAAQQEY ERSSALYQIA IEKWPSNQLL KAGLLDFEKQ FGDINSIEET 300
  301 ISYKRKMEYE TILSNNAYDY DTWWLYLDLI SESFPKQIMQ TFEKAIVDSR PKELSKNVQW 360
  361 KRYIYLWMRY ICYVELELEN SLLEEELFQR LIDDIIPHKH FTFSKIWLMY AKFLIRHDDV 420
  421 PKARKILGKA IGLCPKAKTF KGYIELEVKL KEFDRVRKIY EKFIEFQPSD LQIWSQYGEL 480
  481 EENLGDWDRV RGIYTIALDE NSDFLTKEAK IVLLQKYITF ETESQEFEKA RKLYRRYLEL 540
  541 NQYSPQSWIE FAMYQTSTPT EQQLLDLAKL QSENVDEDIE FEITDENKLE ARKVFEEAIV 600
  601 FFKEKDDKQG RLSILEALKD YEETYGTELD QETVKKRFPK VIKKVRLQNG VEEEFVDYIF 660
  661 PDDIDDDKPK PSKFLELAKK WKQEQAL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BRR2 BUD31 CDC40 CEF1 CLF1 CUS1 CWC2 CWC22 CWC23 HSH155 ISY1 LEA1 PRP11 PRP19 PRP21 PRP31 PRP43 PRP45 PRP46 PRP8 PRP9 RSE1 SMB1 SMD3 SNT309 SNU114 SPP382 STO1 SYF1
    View Details Hazbun TR, et al. (2003) BRR2 CDC40 CEF1 CLF1 CWC2 CWC22 CWC23 CWC25 ECM2 ISY1 LEA1 NTR2 PRP19 PRP43 PRP45 PRP46 PRP8 SMB1 SMD1 SMD3 SMX3 SNT309 SNU114 SPP382 SYF1 SYF2 YJU2
    View Details Krogan NJ, et al. (2006) CEF1 CLF1 ISY1 NTC20 SEC6 SNT309 SYF1 SYF2
    View Details Gavin AC, et al. (2006) CDC40 CEF1 CLF1 CWC2 CWC22 ECM2 PRP19 PRP45 PRP46 SYF1
    View Details Gavin AC, et al. (2002) AAR2 ASC1 BRR1 BUD31 CBC2 CDC33 CDC40 CEF1 CLF1 CSN12 CUS1 CWC2 CWC22 CWC23 DCP2 DHH1 DIB1 ECM2 ERB1 GCN2 HRT1 HSH155 HSH49 HTA1 IMG1 ISY1 KRS1 LEA1 LIN1 LSM1 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 LUC7 MRP7 MRPL28 MRPL3 MRPL35 MRPL38 MRPL4 MRPL8 MRPS5 MSL1 MUD1 NAM7 NAM8 NOG2 NOP1 NPL3 NUG1 PAT1 PRP11 PRP18 PRP19 PRP2 PRP21 PRP22 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP45 PRP46 PRP6 PRP8 PRP9 RSE1 RVB2 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNT309 SNU114 SNU23 SNU56 SNU66 SNU71 SPP381 SPP382 SQS1 SRB2 SRO9 STO1 SYF1 TIF4631 TIF4632 TOS4 UTP21 YEF3 YML6
    View Details Ho Y, et al. (2002) CEF1 CLF1 PRP19 SNT309
    View Details Qiu et al. (2008) AAR2 BRR1 BRR2 BUD31 CBC2 CDC40 CEF1 CLF1 CUS1 CWC15 CWC2 CWC21 CWC22 CWC23 DHR2 DIB1 ECM2 HSH155 ISY1 LSM3 LSM4 LUC7 MAK5 MUD1 MUD2 NAM8 PRP11 PRP16 PRP18 PRP19 PRP2 PRP21 PRP22 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP45 PRP46 PRP5 PRP6 PRP8 PRP9 RSE1 SLD3 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNT309 SNU114 SNU23 SNU56 SNU66 SNU71 SPP2 SPP381 SPP382 STO1 SYF1 SYF2 YHC1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CWC2 No Comments Hazbun TR, et al. (2003)
    View Run SPP382 No Comments Hazbun TR, et al. (2003)
    View Run SPP382 No Comments Hazbun TR, et al. (2003)
    View Run CWC25 No Comments Hazbun TR, et al. (2003)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data CLF1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..154] PSI-BLAST 9.522879 TETRATRICOPEPTIDE REPEATS OF PROTEIN PHOSPHATASE 5
    2 View Details [155..257] ab initio 13.98 No description for 1ihgA was found.
    3 View Details [258..349] ab initio 13.98 No description for 1ihgA was found.
    4 View Details [350..451] PSI-BLAST 35.0 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
    5 View Details [452..525] PSI-BLAST 35.0 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
    6 View Details [526..625] PSI-BLAST 35.0 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
    7 View Details [626..687] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle