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Protein Overview: STT4

General Information:
Name(s) found: STT4 / YLR305C [SGD]
Description(s) found:
Found 25 descriptions.
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  • Phosphatidylinositol-4-kinase that functions in the Pkc1p protein kinase pathway; required for normal vacuole morphology, cell wall integrity, and actin cytoskeleton organization [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1900 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article]
    plasma membrane [IDALink to PubMed article]
    Biological Process: MAPKKK cascade [IDALink to PubMed article][IMPLink to PubMed article]
    phosphatidylethanolamine biosynthetic process [IMPLink to PubMed article]
    vacuole organization [IMPLink to PubMed article]
    phosphoinositide phosphorylation [IMPLink to PubMed article]
    inositol lipid-mediated signaling [TASLink to PubMed article]
    [NOT]protein secretion [IMPLink to PubMed article]
    actin cytoskeleton organization [IMPLink to PubMed article]
    Molecular Function: 1-phosphatidylinositol 4-kinase activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRFTRGLKAS SSLRAKAIGR LTKLSTGAPN DQNSNGTTLD LITHTLPIFY STNTSKIYTI  60
   61 PLTLSEWEVL TSLCVAIPTT LDLVETMLKE IIAPYFLETP RQRISDVLSS KFKLEQMRNP 120
  121 IELLTFQLTK FMIQACEQYP VLYENIGGII STYFERVLKI FTIKQSGLLS LVGFINAFIQ 180
  181 FPNSTELTKF TWKKLAKLVL RGSFLNEVDK ILNSSATFTN DSIVQYYDAG NELSSAYLLE 240
  241 LISRLQVSLI SHLLNTSHVG ANLSEFLLNQ QYQFYKFDQE VADENDDTKC IDDFFFNVRS 300
  301 NKQFFTDMCK ISLQFCSESH ILDLSTDNRA RFSFDTRAHY LQTLCLIPFI EDTESELFES 360
  361 FTNVVSESID KFFLSDVVTP SLIKAIVASA SLLNFFTEKL SLTLIRMFPL LVASPHITTE 420
  421 TVNDVAKIFT TGLYPLNEDA IVSTIYSMNN LLAVSEDGSP VPVLRERQLT ITSGKNIEKD 480
  481 YFPLRNSSAS LDGTGALLGN TTVGQLSSHD VNSGATMTYH ASLISNCVAA TTTIASYYNT 540
  541 QSITALTISI LTQKVNSMSK ELDGVILNSL ARLAPNTSLT EFSLLLKFFK SRTVIATKID 600
  601 DSALLKNIIK AKCVISKELL ARHFSSDLYF MYLHDLLDSI IASGEVERLE HHRPQTEISR 660
  661 VADQIATYLE PLAALLPVPG DTPLDINKDE VTTNKFRNAW FNFVIHGYHL GGPIVKRNFS 720
  721 FLLTIAYNSP PLASEFPANN KELSLEMNTI LRRGSSNENI KQQKQQITEY FNTNIVQYRT 780
  781 TSSSKIMFLA AAVLLETIRC EAGDCSKTLL YFSDPSILSG SIEKCIAVLS VSMIRKYARL 840
  841 IQKGNDAIFN SKMIAQQLNN LLLCLSHREP TLQDAAFHAC EIFIRSIPSS LCHHLSLYTL 900
  901 LDMLTALFDS ILDSEAHKFE PRYEFKLKHS KTTILVPSSS SWRATTLSRL HKSAKEWVRI 960
  961 LLNRSNQDTK ILLQSYISDL GEYSRLNSVE FGVSFAMDMA GLILPADKEL SRLTYYGPEK1020
 1021 PNTISGFISL HSWRSKYLFD TAITSSPEDI KRQIGISTQN IRKNLTLGNK IITKDVTDFL1080
 1081 DMATALLILG NGAPASLIYD IVHIPFEVFT SASLKIATNV WLTIITEKPE VAHLLLVEVC1140
 1141 YCWMRSIDDN IGLYSRDHDL KGEEYQKMEY SPYDKAGINR DAKNASQAMQ PHLHVIKFFA1200
 1201 SHFEGTLFQS DFLLKIFTKC ALYGIKNLYK ASLHPFARMI RHELLLFATL VLNASYKQGS1260
 1261 KYMGRLSQEI TNGALSWFKR PVAWPFGSNE LKIKADLSVT RDLFLQLNKL SSLMSRHCGK1320
 1321 DYKILNYFLA SEIQQIQTWL TPTEKIEGAD SNELTSDIVE ATFAKDPTLA INLLQRCYSK1380
 1381 KAEDVLVGLV AKHALMCVGS PSALDLFIKG SHLSSKKDLH ATLYWAPVSP LKSINLFLPE1440
 1441 WQGNSFILQF SIYSLESQDV NLAFFYVPQI VQCLRYDKTG YVERLILDTA KISVLFSHQI1500
 1501 IWNMLANCYK DDEGIQEDEI KPTLDRIRER MVSSFSQSHR DFYEREFEFF DEVTGISGKL1560
 1561 KPYIKKSKAE KKHKIDEEMS KIEVKPDVYL PSNPDGVVID IDRKSGKPLQ SHAKAPFMAT1620
 1621 FKIKKDVKDP LTGKNKEVEK WQAAIFKVGD DCRQDVLALQ LISLFRTIWS SIGLDVYVFP1680
 1681 YRVTATAPGC GVIDVLPNSV SRDMLGREAV NGLYEYFTSK FGNESTIEFQ NARNNFVKSL1740
 1741 AGYSVISYLL QFKDRHNGNI MYDDQGHCLH IDFGFIFDIV PGGIKFEAVP FKLTKEMVKV1800
 1801 MGGSPQTPAY LDFEELCIKA YLAARPHVEA IIECVNPMLG SGLPCFKGHK TIRNLRARFQ1860
 1861 PQKTDHEAAL YMKALIRKSY ESIFTKGYDE FQRLTNGIPY

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Hazbun TR, et al. (2003) STT4 YPP1
    View Details Krogan NJ, et al. (2006) ATG33 BUB1 CUL3 GUT1 ISM1 MEC3 MLC1 MYO2 MYO4 RGA1 RSB1 SAT4 SHE2 SHE3 SHE4 SRC1 SSH4 STT4 TOF2 TVP18 YDR186C YOL098C
    View Details Gavin AC, et al. (2002) FKS1 NUM1 OPI1 OSH2 PIL1 RPN10 SCS2 STT4 SWH1 YAR044W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run YPP1 No Comments Hazbun TR, et al. (2003)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample zds1 from august 2005 McCusker D, et al (2007)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..505] deduced N/A No confident structure predictions are available.
    2 View Details [506..817] MSA 1.010931 View MSA. No confident structure predictions are available.
    3 View Details [818..1280] deduced N/A No confident structure predictions are available.
    4 View Details [1281..1544] PSI-BLAST 451.9794 Phoshoinositide 3-kinase (PI3K) helical domain; Phoshoinositide 3-kinase (PI3K); Phoshoinositide 3-kinase (PI3K), catalytic domain
    5 View Details [1545..1659]
    [1681..1696]    		 PSI-BLAST 451.9794 Phoshoinositide 3-kinase (PI3K) helical domain; Phoshoinositide 3-kinase (PI3K); Phoshoinositide 3-kinase (PI3K), catalytic domain
    6 View Details [1660..1680]
    [1697..1900]    		 PSI-BLAST 451.9794 Phoshoinositide 3-kinase (PI3K) helical domain; Phoshoinositide 3-kinase (PI3K); Phoshoinositide 3-kinase (PI3K), catalytic domain
    7 View Details [1281..1900] PSI-BLAST 145.0 Phoshoinositide 3-kinase (PI3K) helical domain; Phoshoinositide 3-kinase (PI3K); Phoshoinositide 3-kinase (PI3K), catalytic domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • protein transporter activity
    		•  3.54751411727402 bayes_pls_golite062009
  • transporter activity
    		•  2.3766833486706 bayes_pls_golite062009
  • binding
    		•  2.08129940242136 bayes_pls_golite062009
  • protein binding
    		•  2.0097220759196 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.87445049214426 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  1.29496918547173 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.2724388835449 bayes_pls_golite062009
  • protein kinase activity
    		•  0.810649007742052 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.80477645195818 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.458765492668419 bayes_pls_golite062009
  • kinase activity
    		•  0.457930590956078 bayes_pls_golite062009
  • nuclear localization sequence binding
    		•  0.446146092845179 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.325164716012293 bayes_pls_golite062009
  • clathrin binding
    		•  0.267269093785234 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.260663498540354 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.109457212542021 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.0128158555898987 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.00672548245940896 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7
    Term Confidence Notes
  • protein kinase activity
    		•  4.85949258240629 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  4.32184067232044 bayes_pls_golite062009
  • kinase activity
    		•  4.16135267871365 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  3.92556971928915 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  3.76541923765309 bayes_pls_golite062009
  • transferase activity
    		•  2.57136779276375 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  2.49185236546092 bayes_pls_golite062009
  • phosphoinositide 3-kinase activity
    		•  2.44230772088939 bayes_pls_golite062009
  • 1-phosphatidylinositol-3-kinase activity
    		•  2.31725772204126 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  2.10205527715406 bayes_pls_golite062009
  • binding
    		•  1.86908674572736 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.78809750269485 bayes_pls_golite062009
  • ATP binding
    		•  1.62950013799854 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  1.62540675397712 bayes_pls_golite062009
  • protein binding
    		•  1.62406684925162 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  1.61399284935575 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.59120412984243 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.57251948653832 bayes_pls_golite062009
  • SNARE binding
    		•  1.50911134971955 bayes_pls_golite062009
  • calcium-dependent phospholipid binding
    		•  1.48140651026963 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.47984425211758 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.32931505255952 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.32676572752438 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.31489723493061 bayes_pls_golite062009
  • nucleotide binding
    		•  1.31339663939554 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • transporter activity
    		•  1.11833481501707 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.08569774189413 bayes_pls_golite062009
  • signal transducer activity
    		•  1.08569774189413 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.05349866588938 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.97575992765505 bayes_pls_golite062009
  • nuclear localization sequence binding
    		•  0.865986250813399 bayes_pls_golite062009
  • platelet-derived growth factor receptor binding
    		•  0.863546778345754 bayes_pls_golite062009
  • syntaxin binding
    		•  0.860722375330019 bayes_pls_golite062009
  • phospholipase C activity
    		•  0.7749932550949 bayes_pls_golite062009
  • lipid kinase activity
    		•  0.74363752721495 bayes_pls_golite062009
  • phospholipase activity
    		•  0.689713182053935 bayes_pls_golite062009
  • receptor activity
    		•  0.565672931530981 bayes_pls_golite062009
  • clathrin binding
    		•  0.53271167669517 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.451090007290896 bayes_pls_golite062009
  • nuclear export signal receptor activity
    		•  0.407635284358481 bayes_pls_golite062009
  • inositol or phosphatidylinositol kinase activity
    		•  0.328918574945998 bayes_pls_golite062009
  • protein transporter activity
    		•  0.322729515821394 bayes_pls_golite062009
  • kinase binding
    		•  0.26752427107238 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.252495966234234 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.205652638854091 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.134745748018448 bayes_pls_golite062009
  • neurexin binding
    		•  0.10203540130895 bayes_pls_golite062009
  • growth factor binding
    		•  0.0282286028179795 bayes_pls_golite062009
  • protein kinase binding
    		•  0.00674998152095019 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.00492507437049428 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.72

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle