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Protein Overview: RAS2

General Information:
Name(s) found: RAS2 / YNL098C [SGD]
Description(s) found:
Found 33 descriptions.
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  • GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 322 amino acids

    Gene Ontology:
    Cellular Component: plasma membrane [IDALink to PubMed article][TASLink to PubMed article]
    Biological Process: ascospore formation [IMPLink to PubMed article]
    pseudohyphal growth [IMPLink to PubMed article]
    Ras protein signal transduction [TASLink to PubMed article]
    positive regulation of transcription by galactose [IMPLink to PubMed article]
    replicative cell aging [IMPLink to PubMed article]
    activation of adenylate cyclase activity [TASLink to PubMed article]
    Molecular Function: GTPase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPLNKSNIRE YKLVVVGGGG VGKSALTIQL TQSHFVDEYD PTIEDSYRKQ VVIDDEVSIL  60
   61 DILDTAGQEE YSAMREQYMR NGEGFLLVYS ITSKSSLDEL MTYYQQILRV KDTDYVPIVV 120
  121 VGNKSDLENE KQVSYQDGLN MAKQMNAPFL ETSAKQAINV EEAFYTLARL VRDEGGKYNK 180
  181 TLTENDNSKQ TSQDTKGSGA NSVPRNSGGH RKMSNAANGK NVNSSTTVVN ARNASIESKT 240
  241 GLAGNQATNG KTQTDRTNID NSTGQAGQAN AQSANTVNNR VNNNSKAGQV SNAKQARKQQ 300
  301 AAPGGNTSEA SKSGSGGCCI IS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) RAS1 RAS2
    View Details Ho Y, et al. (2002) IRA1 RAS1 RAS2 TSR1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen RAS2 RTG3 2 Unpublished Fields Lab Data
    View Screen RAS2 SPS18 2 Unpublished Fields Lab Data
    View Screen RAS2 YLR445W 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data RAS2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..185] PSI-BLAST 609.0 cH-p21 Ras protein
    2 View Details [186..322] MSA 1.824995 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • GTPase activity
    		•  4.52394549632777 bayes_pls_golite062009
  • motor activity
    		•  4.04927796049806 bayes_pls_golite062009
  • microtubule motor activity
    		•  3.91769993918004 bayes_pls_golite062009
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•  3.57926427233638 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  3.4837867129694 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  3.35436118751376 bayes_pls_golite062009
  • transporter activity
    		•  3.10463051760206 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  3.08390071341252 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.95886887664984 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.95079405147356 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.87427509025394 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.85499564954033 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.85178667290149 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  2.61775212528604 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  2.61467977505707 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  2.61311581579476 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  2.57552435627908 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  2.57107347424517 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  2.57054427875021 bayes_pls_golite062009
  • hydrolase activity
    		•  2.55157966585974 bayes_pls_golite062009
  • microfilament motor activity
    		•  2.51786963027655 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.51683451033161 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  2.50494515048649 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  2.43862163407966 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.4101693596493 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  2.40292717311506 bayes_pls_golite062009
  • ATPase activity
    		•  2.39535714892224 bayes_pls_golite062009
  • actin binding
    		•  2.2973522188675 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  2.26365379756656 bayes_pls_golite062009
  • DNA binding
    		•  2.12258000781149 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.09345198747025 bayes_pls_golite062009
  • tubulin binding
    		•  1.92557767696163 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.91091452720653 bayes_pls_golite062009
  • guanyl nucleotide binding
    		•  1.89320355239381 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  1.88721318481223 bayes_pls_golite062009
  • GTP binding
    		•  1.87900088157196 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.85943679361938 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.85937484083653 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.8521191028835 bayes_pls_golite062009
  • nucleotide binding
    		•  1.84603132945448 bayes_pls_golite062009
  • microtubule binding
    		•  1.84561785126784 bayes_pls_golite062009
  • kinase activity
    		•  1.80889641165674 bayes_pls_golite062009
  • helicase activity
    		•  1.70242731830224 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  1.63949223587737 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.60386625568858 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  1.58971273330352 bayes_pls_golite062009
  • ATP binding
    		•  1.5859264197035 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.55520429131224 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.53158018507951 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  1.47858140861683 bayes_pls_golite062009
  • actin filament binding
    		•  1.28204719195916 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of ions
    		•  1.23799860254751 bayes_pls_golite062009
  • protein binding
    		•  1.22129154759482 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  1.2155186842031 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.14475274823167 bayes_pls_golite062009
  • protein kinase activity
    		•  1.12864835254143 bayes_pls_golite062009
  • nucleotide kinase activity
    		•  1.10251779925246 bayes_pls_golite062009
  • beta-catenin binding
    		•  1.03146778136145 bayes_pls_golite062009
  • apolipoprotein receptor activity
    		•  1.02132483910092 bayes_pls_golite062009
  • syntaxin-13 binding
    		•  1.02132483910092 bayes_pls_golite062009
  • apolipoprotein A-I binding
    		•  1.02132483910092 bayes_pls_golite062009
  • apolipoprotein A-I receptor activity
    		•  1.02132483910092 bayes_pls_golite062009
  • GDP-dissociation inhibitor binding
    		•  1.01467127484205 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • cation channel activity
    		•  0.997064416395892 bayes_pls_golite062009
  • GMP binding
    		•  0.975301479415235 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  0.971476020912368 bayes_pls_golite062009
  • DNA polymerase activity
    		•  0.928091843881235 bayes_pls_golite062009
  • actin-dependent ATPase activity
    		•  0.92105578610354 bayes_pls_golite062009
  • transcription activator activity
    		•  0.889929694023098 bayes_pls_golite062009
  • transcription factor activity
    		•  0.887108427603557 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  0.876296121718575 bayes_pls_golite062009
  • transferase activity
    		•  0.871779313294914 bayes_pls_golite062009
  • structural molecule activity
    		•  0.86514677273731 bayes_pls_golite062009
  • structural constituent of muscle
    		•  0.842950252373832 bayes_pls_golite062009
  • copper ion transmembrane transporter activity
    		•  0.816469301666725 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.782430219754236 bayes_pls_golite062009
  • di-, tri-valent inorganic cation transmembrane transporter activity
    		•  0.767424210804186 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.72881469450553 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  0.688632087597536 bayes_pls_golite062009
  • signal transducer activity
    		•  0.683309012097319 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.683309012097319 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.661834961742057 bayes_pls_golite062009
  • protein-DNA loading ATPase activity
    		•  0.650964453464311 bayes_pls_golite062009
  • steroid hormone receptor binding
    		•  0.647625526012423 bayes_pls_golite062009
  • calcium channel activity
    		•  0.636216614902039 bayes_pls_golite062009
  • receptor activity
    		•  0.633514002718998 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  0.63002958837536 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.6071273686445 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.5886142102548 bayes_pls_golite062009
  • plus-end-directed microtubule motor activity
    		•  0.567883621045161 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  0.562664200036023 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  0.559798751382976 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.543891899378373 bayes_pls_golite062009
  • DNA clamp loader activity
    		•  0.543512707823441 bayes_pls_golite062009
  • protein transporter activity
    		•  0.498432226280822 bayes_pls_golite062009
  • DNA strand annealing activity
    		•  0.495691434532349 bayes_pls_golite062009
  • anion transmembrane transporter activity
    		•  0.43332053110728 bayes_pls_golite062009
  • phosphotransferase activity, phosphate group as acceptor
    		•  0.40217318916177 bayes_pls_golite062009
  • drug transmembrane transporter activity
    		•  0.38711726712063 bayes_pls_golite062009
  • hormone receptor binding
    		•  0.351501100511918 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.345873656782869 bayes_pls_golite062009
  • potassium channel activity
    		•  0.329290830676079 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.328170855722634 bayes_pls_golite062009
  • gated channel activity
    		•  0.299411774392227 bayes_pls_golite062009
  • translation regulator activity
    		•  0.29096092258568 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.274994961137851 bayes_pls_golite062009
  • transition metal ion transmembrane transporter activity
    		•  0.248918847596573 bayes_pls_golite062009
  • nuclear hormone receptor binding
    		•  0.246160342138071 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.243902356228423 bayes_pls_golite062009
  • RNA helicase activity
    		•  0.18426050934025 bayes_pls_golite062009
  • ion channel activity
    		•  0.154779598791225 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  0.14606996093053 bayes_pls_golite062009
  • channel activity
    		•  0.134817721656507 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.134817721656507 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  0.13050483816765 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.126911677161968 bayes_pls_golite062009
  • nucleobase, nucleoside, nucleotide kinase activity
    		•  0.12351419478929 bayes_pls_golite062009
  • voltage-gated calcium channel activity
    		•  0.0789800146503108 bayes_pls_golite062009
  • cation-transporting ATPase activity
    		•  0.0536898657672154 bayes_pls_golite062009
  • inorganic anion transmembrane transporter activity
    		•  0.0122470146764899 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.0111338193708552 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.87

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle