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Protein Overview: ESA1

General Information:
Name(s) found: ESA1 / YOR244W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Catalytic subunit of the histone acetyltransferase complex (NuA4) that acetylates four conserved internal lysines of histone H4 N-terminal tail; required for cell cycle progression and transcriptional silencing at the rDNA locus [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 445 amino acids

    Gene Ontology:
    Cellular Component: NuA4 histone acetyltransferase complex [IPILink to PubMed articleLink to PubMed article]
    Piccolo NuA4 histone acetyltransferase complex [IDALink to PubMed article]
    histone acetyltransferase complex [IDALink to PubMed article]
    Biological Process: DNA repair [IDALink to PubMed article][IMPLink to PubMed article]
    RNA elongation [IDALink to PubMed article][IMPLink to PubMed article]
    histone acetylation [IDALink to PubMed article]
    regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed article]
    Molecular Function: histone acetyltransferase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSHDGKEEPG IAKKINSVDD IIIKCQCWVQ KNDEERLAEI LSINTRKAPP KFYVHYVNYN  60
   61 KRLDEWITTD RINLDKEVLY PKLKATDEDN KKQKKKKATN TSETPQDSLQ DGVDGFSREN 120
  121 TDVMDLDNLN VQGIKDENIS HEDEIKKLRT SGSMTQNPHE VARVRNLNRI IMGKYEIEPW 180
  181 YFSPYPIELT DEDFIYIDDF TLQYFGSKKQ YERYRKKCTL RHPPGNEIYR DDYVSFFEID 240
  241 GRKQRTWCRN LCLLSKLFLD HKTLYYDVDP FLFYCMTRRD ELGHHLVGYF SKEKESADGY 300
  301 NVACILTLPQ YQRMGYGKLL IEFSYELSKK ENKVGSPEKP LSDLGLLSYR AYWSDTLITL 360
  361 LVEHQKEITI DEISSMTSMT TTDILHTAKT LNILRYYKGQ HIIFLNEDIL DRYNRLKAKK 420
  421 RRTIDPNRLI WKPPVFTASQ LRFAW

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ARP4 EAF1 EAF3 EAF5 EAF6 EAF7 EPL1 ESA1 SWC4 TRA1 YAF9 YNG2
    View Details Hazbun TR, et al. (2003) ARP4 EAF1 EAF5 EPL1 ESA1 RVB1 RVB2 SWC4 SWR1 TRA1 YAF9 YNG2
    View Details (MIPS) Mewes HW, et al. (2004) ESA1 TRA1
    View Details Krogan NJ, et al. (2006) ARP4 ARP5 ARP6 ARP8 CCA1 EAF1 EAF5 EAF6 EAF7 EPL1 ESA1 IES1 IES2 IES3 IES4 IES5 IES6 INO80 NHP10 NTO1 PIH1 RVB1 RVB2 SAS3 SWC3 SWC4 SWC5 SWC7 SWR1 TAH1 TRA1 VPS71 VPS72 YAF9 YNG2
    View Details Gavin AC, et al. (2006) EPL1 ESA1
    View Details Gavin AC, et al. (2002) ACT1 ADH1 ARP4 EAF1 EAF3 EAF5 EPL1 ESA1 HHF1, HHF2 TRA1 YAF9 YAP1
    View Details Ho Y, et al. (2002) ARP4 ATE1 CDC33 CKA2 EAF1 EPL1 ESA1 HRR25 POR1 SAP185 SIT4 TAF14 TAF4 TIP41 TRA1 TUF1 YRA1
    View Details Qiu et al. (2008) AHC1 ARP4 EPL1 ESA1 GCN5 TRA1 YNG1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run SWC4 No Comments Hazbun TR, et al. (2003)
    View Run SWC4 No Comments Hazbun TR, et al. (2003)
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ESA1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..141] Pcons 1.5 Heterochromatin protein 1, HP1
    2 View Details [142..218] PSI-BLAST 1714.0 Histone acetyltransferase ESA1
    3 View Details [219..314] PSI-BLAST 1714.0 Histone acetyltransferase ESA1
    4 View Details [315..350]
    [421..445]    		 PSI-BLAST 1714.0 Histone acetyltransferase ESA1
    5 View Details [351..420] PSI-BLAST 1714.0 Histone acetyltransferase ESA1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription repressor activity
    		•  4.08500855631983 bayes_pls_golite062009
  • chromatin binding
    		•  3.84065302930105 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.64390820819794 bayes_pls_golite062009
  • methylated histone residue binding
    		•  3.42338304360938 bayes_pls_golite062009
  • binding
    		•  3.06758476214113 bayes_pls_golite062009
  • protein binding
    		•  2.66728689880621 bayes_pls_golite062009
  • transcription elongation regulator activity
    		•  2.46353586381231 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.19167058827256 bayes_pls_golite062009
  • DNA binding
    		•  2.05514577638135 bayes_pls_golite062009
  • histone binding
    		•  2.00388175060339 bayes_pls_golite062009
  • transcription activator activity
    		•  1.46529895769882 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.10020047862576 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.998957812785999 bayes_pls_golite062009
  • general transcriptional repressor activity
    		•  0.75184432495983 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.726970683178132 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.494788451379878 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.294457188332415 bayes_pls_golite062009
  • catalytic activity
    		•  0.14067200158938 bayes_pls_golite062009
    2
    Term Confidence Notes
  • N-acetyltransferase activity
    		•  10.330867741687 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  10.2385402730839 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  10.2385402730839 bayes_pls_golite062009
  • N-acyltransferase activity
    		•  10.2097972775096 bayes_pls_golite062009
  • acetyltransferase activity
    		•  9.5414870492393 bayes_pls_golite062009
  • acyltransferase activity
    		•  8.84144467104026 bayes_pls_golite062009
  • transferase activity, transferring acyl groups other than amino-acyl groups
    		•  8.80032457938662 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  8.58458341779614 bayes_pls_golite062009
    		• 7.30820970670781 bayes_pls_golite062009
    		• 5.22897636875434 bayes_pls_golite062009
  • H3 histone acetyltransferase activity
    		•  3.57980162499154 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  2.87587084880956 bayes_pls_golite062009
  • transferase activity
    		•  2.87429355361226 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.24760844790231 bayes_pls_golite062009
  • transcription activator activity
    		•  2.22111981353244 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.13750665291344 bayes_pls_golite062009
  • catalytic activity
    		•  1.97933499002461 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.31507488567214 bayes_pls_golite062009
  • binding
    		•  1.22537494136129 bayes_pls_golite062009
  • transcription coactivator activity
    		•  1.2180007740195 bayes_pls_golite062009
  • transcription factor binding
    		•  1.13174003342838 bayes_pls_golite062009
  • protein binding
    		•  1.12627968510377 bayes_pls_golite062009
  • glycylpeptide N-tetradecanoyltransferase activity
    		•  0.774009286200155 bayes_pls_golite062009
  • myristoyltransferase activity
    		•  0.774009286200155 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.605899196605446 bayes_pls_golite062009
  • histone binding
    		•  0.582104626133107 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.31196049232138 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle