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Protein Overview: NAB3

General Information:
Name(s) found: NAB3 / YPL190C [SGD]
Description(s) found:
Found 26 descriptions.
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  • Single stranded RNA binding protein; acidic ribonucleoprotein; required for termination of non-poly(A) transcripts and efficient splicing; interacts with Nrd1p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 802 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: termination of RNA polymerase II transcription, poly(A)-independent [IMPLink to PubMed article]
    regulation of transcription from RNA polymerase II promoter [IGILink to PubMed article][IPILink to PubMed article]
    Molecular Function: poly(A) RNA binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDENHNSDV QDIPSPELSV DSNSNENELM NNSSADDGIE FDAPEEEREA EREEENEEQH  60
   61 ELEDVNDEEE EDKEEKGEEN GEVINTEEEE EEEHQQKGGN DDDDDDNEEE EEEEEDDDDD 120
  121 DDDDDDDEEE EEEEEEEGND NSSVGSDSAA EDGEDEEDKK DKTKDKEVEL RRETLEKEQK 180
  181 DVDEAIKKIT REENDNTHFP TNMENVNYDL LQKQVKYIMD SNMLNLPQFQ HLPQEEKMSA 240
  241 ILAMLNSNSD TALSVPPHDS TISTTASASA TSGARSNDQR KPPLSDAQRR MRFPRADLSK 300
  301 PITEEEHDRY AAYLHGENKI TEMHNIPPKS RLFIGNLPLK NVSKEDLFRI FSPYGHIMQI 360
  361 NIKNAFGFIQ FDNPQSVRDA IECESQEMNF GKKLILEVSS SNARPQFDHG DHGTNSSSTF 420
  421 ISSAKRPFQT ESGDMYNDDN GAGYKKSRRH TVSCNIFVKR TADRTYAIEV FNRFRDGTGL 480
  481 ETDMIFLKPR MELGKLINDA AYNGVWGVVL VNKTHNVDVQ TFYKGSQGET KFDEYISISA 540
  541 DDAVAIFNNI KNNRNNSRPT DYRAMSHQQN IYGAPPLPVP NGPAVGPPPQ TNYYQGYSMP 600
  601 PPQQQQQQPY GNYGMPPPSH DQGYGSQPPI PMNQSYGRYQ TSIPPPPPQQ QIPQGYGRYQ 660
  661 AGPPPQPPSQ TPMDQQQLLS AIQNLPPNVV SNLLSMAQQQ QQQPHAQQQL VGLIQSMQGQ 720
  721 APQQQQQQLG GYSSMNSSSP PPMSTNYNGQ NISAKPSAPP MSHQPPPPQQ QQQQQQQQQQ 780
  781 QQQQPAGNNV QSLLDSLAKL QK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) AIR2 CBC2 KAP95 MTR4 NAB3 NAB6 NPL3 NRD1 PAP2 STO1 TIF4632
    View Details Krogan NJ, et al. (2006) GAT1 NAB3 NRD1
    View Details Gavin AC, et al. (2006) MTR4 NAB3 NRD1 SEN1 STO1
    View Details Gavin AC, et al. (2002) AIR2 BRR1 BUR2 CBC2 CLU1 CRN1 ECM29 GCN1 HCA4 HTA1 IML1 KAP123 KAP95 LHP1 LUC7 MEC1 MIP6 MIS1 MRPL23 MSH4 MTR4 MUD1 NAB3 NAB6 NAM7 NAM8 NPL3 NRD1 NRP1 NUP60 POL2 PRP39 PRP40 PRP42 PUB1 ROM2 RPA135 RSE1 SCP160 SEN1 SEN54 SGN1 SGV1 SMD1 SMD2 SMD3 SNF2 SNP1 SNU56 SNU71 SRO9 SRP1 STO1 SUI3 SUP35 SUP45 SWI1 TAO3 THO2 TIF4631 TIF4632 USO1 UTP20 VAC14 VPS5 YJL017W YRA2
    View Details Qiu et al. (2008) NAB3 NPL3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen PCF11 NAB3 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data NAB3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..116] deduced N/A No confident structure predictions are available.
    2 View Details [117..400] PSI-BLAST 3.154902 Botulinum neurotoxin
    3 View Details [401..558] deduced N/A No confident structure predictions are available.
    4 View Details [559..802] MSA 35.060997 View MSA. No confident structure predictions are available.
    5 View Details [679..802] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.40096962515027 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.15398264148864 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.95513305822187 bayes_pls_golite062009
  • DNA binding
    		•  1.80079581406991 bayes_pls_golite062009
  • transcription factor activity
    		•  1.15427978494805 bayes_pls_golite062009
  • protein binding
    		•  0.757492117682468 bayes_pls_golite062009
    2
    Term Confidence Notes
  • nucleic acid binding
    		•  4.65259034341669 bayes_pls_golite062009
  • binding
    		•  3.48033873254013 bayes_pls_golite062009
  • RNA binding
    		•  2.51560202858525 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.2045206027152 bayes_pls_golite062009
  • DNA binding
    		•  1.99030664201171 bayes_pls_golite062009
  • mRNA binding
    		•  1.52376515340629 bayes_pls_golite062009
  • transcription factor activity
    		•  1.09958329302628 bayes_pls_golite062009
  • protein binding
    		•  1.05805521997665 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.633093884585572 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.327072171076297 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle