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View Structure Prediction Details

Protein: DIN7_YEAST
Organism: Saccharomyces cerevisiae S288c
Length: 430 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DIN7_YEAST.

Description E-value Query
Range
Subject
Range
gi|190404789 - gi|190404789|gb|EDV08056.1| DNA damage-inducible protein DIN7 [Saccharomyces cerevisiae RM11-1a]
DIN7_YEAST - DNA damage-inducible protein DIN7 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DIN7 P...
DIN7 - Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mit...
gi|151942240 - gi|151942240|gb|EDN60596.1| DNA damage-inducible protein [Saccharomyces cerevisiae YJM789]
0.0 [1..430] [1..430]
gi|15778123 - gi|15778123|dbj|BAB68507.1| FEN-1 nuclease [Gallus gallus]
2.0E-86 [1..390] [1..379]
FEN1_PLAFA - Flap endonuclease 1 OS=Plasmodium falciparum GN=FEN1 PE=2 SV=1
1.0E-84 [1..409] [1..423]
gi|11559508 - gi|11559508|gb|AAG37989.1|AF093702_1 flap endonuclease 1 [Plasmodium falciparum]
FEN1_PLAF7 - Flap endonuclease 1 OS=Plasmodium falciparum (isolate 3D7) GN=FEN1 PE=3 SV=1
2.0E-83 [1..409] [1..423]
gi|26337949, gi|... - gi|74185061|dbj|BAE39135.1| unnamed protein product [Mus musculus], gi|74150381|dbj|BAE32236.1| unna...
5.0E-83 [1..367] [1..358]
gi|8896169, gi|1... - gi|8896169|gb|AAF81265.1|AF281018_1 flag structure-specific endonuclease [Rattus norvegicus], gi|167...
2.0E-82 [1..367] [1..358]
FEN1_SCHPO - Flap endonuclease 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=rad2 PE=1 SV=1
rad2 - FEN-1 endonuclease
2.0E-80 [1..387] [1..379]
Fen1-PA - The gene Flap endonuclease 1 is referred to in FlyBase by the symbol Dmel\Fen1 (CG8648, FBgn0025832)...
4.0E-80 [1..373] [1..361]

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Predicted Domain #1
Region A:
Residues: [1-349]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGIPGLLPQL KRIQKQVSLK KYMYQTLAID GYAWLHRASC ACAFELVMNK PTNKYLQFFI  60
   61 KRLQLLKRLK IKPYIVFDGD SLFVKNHTET RRRKKRLENE MIAKKLWSAG NRYNAMEYFQ 120
  121 KSVDITPEMA KCIIDYCKLH SIPYIVAPFE ADPQMVYLEK MGLIQGIISE DSDLLVFGCK 180
  181 TLITKLNDQG KALEISKDDF SALPENFPLG ELSEQQFRNL VCLAGCDYTS GIWKVGVVTA 240
  241 MKIVKRYSEM KDILIQIERT EKLCFSKAFK QQVEFANYAF QYQRVFCPLS NQITTLNNIP 300
  301 KAVTNSHAEI IKIMKCIGSV VERGSGVRKD VINTKNIDHK VHEMIAKGE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 164.0103
Match: 1a76__
Description: Flap endonuclease-1 (Fen-1 nuclease)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
flap endonuclease activity 3.67578601858151 bayes_pls_golite062009
endodeoxyribonuclease activity 3.29138075959109 bayes_pls_golite062009
deoxyribonuclease activity 3.25110450559975 bayes_pls_golite062009
exonuclease activity 3.08589196968812 bayes_pls_golite062009
5'-3' exonuclease activity 2.82147159438565 bayes_pls_golite062009
nuclease activity 2.11339581411994 bayes_pls_golite062009
exodeoxyribonuclease activity 2.0005433655378 bayes_pls_golite062009
exodeoxyribonuclease activity, producing 5'-phosphomonoesters 1.9833086883205 bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1.91303769651266 bayes_pls_golite062009
5'-3' exodeoxyribonuclease activity 1.87664153967776 bayes_pls_golite062009
double-stranded DNA specific exodeoxyribonuclease activity 1.68933217523176 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 1.6357876066979 bayes_pls_golite062009
hydrolase activity 1.55146225298048 bayes_pls_golite062009
5'-flap endonuclease activity 1.44561869581238 bayes_pls_golite062009
endonuclease activity 1.40552749109921 bayes_pls_golite062009
catalytic activity 1.37534898662234 bayes_pls_golite062009
single-stranded DNA specific exodeoxyribonuclease activity 1.27080587821961 bayes_pls_golite062009
DNA binding 1.0824699122398 bayes_pls_golite062009
binding 1.04616076007281 bayes_pls_golite062009
nucleic acid binding 1.03274122519509 bayes_pls_golite062009
damaged DNA binding 0.98172679437643 bayes_pls_golite062009
single-stranded DNA specific 5'-3' exodeoxyribonuclease activity 0.807459896574807 bayes_pls_golite062009
structure-specific DNA binding 0.71603644615457 bayes_pls_golite062009
endodeoxyribonuclease activity, producing 5'-phosphomonoesters 0.620251812982006 bayes_pls_golite062009
protein binding 0.236485289446406 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [350-430]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LHPVDMASKL INRERKLKAR KLFKVGLLGG ESNSFNKKVE QPLVDTQDVL SERENSLDNK  60
   61 NASSIYMTSP AAISGTVPSI F

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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