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View Structure Prediction Details

Protein: YL455_YEAST
Organism: Saccharomyces cerevisiae S288c
Length: 304 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YL455_YEAST.

Description E-value Query
Range
Subject
Range
YLR455W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to th...
YL455_YEAST - PWWP domain-containing protein YLR455W OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=Y...
4.0E-79 [1..304] [1..304]
SPBC29A3.13 - PWWP domain protein
PDP1_SCHPO - PWWP domain-containing protein 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=pdp1 PE=1...
5.0E-60 [5..290] [50..350]
gi|5823166, gi|2... - gi|5823166|gb|AAD53062.1|AF156487_1 DNA cytosine-5 methyltransferase 3 beta 3 [Homo sapiens], gi|574...
5.0E-39 [3..222] [221..452]
GLYR1_MOUSE - Putative oxidoreductase GLYR1 OS=Mus musculus GN=Glyr1 PE=1 SV=1
1.0E-38 [4..198] [5..178]

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Predicted Domain #1
Region A:
Residues: [1-83]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTKDIRTGDL VLCKVGSFPP WPAVVFPQRL LRNDVYRKRK SNCVAVCFFN DPTYYWEQPS  60
   61 RLKELDQDSI HNFILEHSKN ANQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.045757
Match: 1khcA_
Description: DNA methyltransferase DNMT3B
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.4854263045204 bayes_pls_golite062009
protein binding 1.51678357126614 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [84-145]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RELVNAYKEA KNFDDFNVFL QEKFEEENRL SDLKAFEKSE GSKIVAGEDP FVGRTKVVNK  60
   61 RK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.045757
Match: 1khcA_
Description: DNA methyltransferase DNMT3B
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [146-242]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KNSISIKEDP EDNQKSNEEE SKPNIKPSKK KRPTANSGGK SNSGNKKKVK LDYSRRVEIS  60
   61 QLFRRRIQRN LIQRETPPTE HEIKETHELL NRIYENS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.412 0.522 nucleus a.39.1 EF-hand
View Download 0.364 0.001 nucleus a.156.1 S13-like H2TH domain
View Download 0.349 0.001 nucleus a.91.1 Regulator of G-protein signalling, RGS
View Download 0.326 0.000 nucleus d.199.1 DNA-binding C-terminal domain of the transcription factor MotA
View Download 0.342 N/A N/A d.54.1 Enolase N-terminal domain-like
View Download 0.326 N/A N/A a.142.1 PTS-regulatory domain, PRD
View Download 0.258 N/A N/A a.60.5 Barrier-to-autointegration factor, BAF
View Download 0.247 N/A N/A a.7.6 Ribosomal protein S20
View Download 0.238 N/A N/A d.192.1 YlxR-like
View Download 0.212 N/A N/A a.142.1 PTS-regulatory domain, PRD
View Download 0.212 N/A N/A a.29.2 Bromodomain
View Download 0.205 N/A N/A a.61.1 Retroviral matrix proteins
View Download 0.203 N/A N/A d.192.1 YlxR-like
View Download 0.201 N/A N/A a.181.1 Antibiotic binding domain of TipA-like multidrug resistance regulators

Predicted Domain #4
Region A:
Residues: [243-304]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DTKRPFFDLK ALRESKLHKL LKAIVNDPDL GEFHPLCKEI LLSWADLITE LKKEKLQALP  60
   61 TP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.689 0.966 nucleus a.4.1 Homeodomain-like
View Download 0.760 0.966 nucleus a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.629 0.966 nucleus a.60.2 RuvA domain 2-like
View Download 0.626 0.966 nucleus a.4.1 Homeodomain-like
View Download 0.618 0.966 nucleus a.159.2 FF domain
View Download 0.598 0.966 nucleus a.64.1 Saposin
View Download 0.574 0.966 nucleus a.2.7 tRNA-binding arm
View Download 0.540 0.966 nucleus d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.528 0.966 nucleus a.157.1 Skp1 dimerisation domain-like
View Download 0.517 0.966 nucleus a.4.1 Homeodomain-like
View Download 0.516 0.966 nucleus a.4.5 "Winged helix" DNA-binding domain
View Download 0.504 0.966 nucleus a.4.1 Homeodomain-like
View Download 0.487 0.966 nucleus a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.481 0.966 nucleus a.159.2 FF domain
View Download 0.478 0.966 nucleus a.57.1 Protein HNS-dependent expression A; HdeA
View Download 0.475 0.966 nucleus a.4.1 Homeodomain-like
View Download 0.459 0.966 nucleus a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.453 0.966 nucleus a.2.7 tRNA-binding arm
View Download 0.413 0.966 nucleus a.28.3 Retrovirus capsid protein C-terminal domain
View Download 0.406 0.966 nucleus d.39.1 Dynein light chain 8 (DLC8)
View Download 0.401 0.966 nucleus d.54.1 Enolase N-terminal domain-like
View Download 0.375 0.966 nucleus a.2.7 tRNA-binding arm
View Download 0.368 0.966 nucleus a.85.1 Hemocyanin, N-terminal domain
View Download 0.368 0.966 nucleus a.11.1 Acyl-CoA binding protein
View Download 0.357 0.966 nucleus a.4.1 Homeodomain-like
View Download 0.355 0.966 nucleus a.11.1 Acyl-CoA binding protein
View Download 0.348 0.966 nucleus a.2.7 tRNA-binding arm
View Download 0.343 0.966 nucleus a.157.1 Skp1 dimerisation domain-like
View Download 0.340 0.966 nucleus a.4.5 "Winged helix" DNA-binding domain
View Download 0.335 0.966 nucleus a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.332 0.966 nucleus a.4.1 Homeodomain-like
View Download 0.326 0.966 nucleus a.3.1 Cytochrome c
View Download 0.324 0.966 nucleus a.108.1 Ribosomal protein L7/12, oligomerisation (N-terminal) domain
View Download 0.321 0.966 nucleus a.4.5 "Winged helix" DNA-binding domain
View Download 0.315 0.966 nucleus a.153.1 Nuclear receptor coactivator interlocking domain
View Download 0.315 0.966 nucleus a.153.1 Nuclear receptor coactivator interlocking domain
View Download 0.313 0.966 nucleus a.4.1 Homeodomain-like
View Download 0.313 0.966 nucleus a.157.1 Skp1 dimerisation domain-like
View Download 0.312 0.966 nucleus a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.310 0.966 nucleus a.4.1 Homeodomain-like
View Download 0.308 0.966 nucleus a.118.11 Cytochrome c oxidase subunit E
View Download 0.307 0.966 nucleus a.108.1 Ribosomal protein L7/12, oligomerisation (N-terminal) domain
View Download 0.306 0.966 nucleus a.4.8 Ribosomal protein S18
View Download 0.297 0.966 nucleus a.77.1 DEATH domain
View Download 0.297 0.966 nucleus a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.293 0.966 nucleus a.157.1 Skp1 dimerisation domain-like
View Download 0.292 0.966 nucleus a.50.1 Anaphylotoxins (complement system)
View Download 0.290 0.966 nucleus a.16.1 S15/NS1 RNA-binding domain
View Download 0.289 0.966 nucleus a.118.8 TPR-like
View Download 0.283 0.966 nucleus a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.281 0.966 nucleus a.39.1 EF-hand
View Download 0.278 0.966 nucleus a.81.1 N-terminal domain of DnaB helicase
View Download 0.266 0.966 nucleus a.159.2 FF domain
View Download 0.262 0.966 nucleus d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.262 0.966 nucleus a.157.1 Skp1 dimerisation domain-like
View Download 0.258 0.966 nucleus a.4.5 "Winged helix" DNA-binding domain
View Download 0.253 0.966 nucleus a.65.1 Annexin
View Download 0.249 0.966 nucleus a.157.1 Skp1 dimerisation domain-like
View Download 0.247 0.966 nucleus d.58.24 CheY-binding domain of CheA
View Download 0.242 0.966 nucleus a.126.1 Serum albumin-like
View Download 0.242 0.966 nucleus c.15.1 BRCT domain
View Download 0.238 0.966 nucleus a.4.1 Homeodomain-like
View Download 0.236 0.966 nucleus a.108.1 Ribosomal protein L7/12, oligomerisation (N-terminal) domain
View Download 0.236 0.966 nucleus a.4.12 TrpR-like
View Download 0.236 0.966 nucleus a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.235 0.966 nucleus a.60.2 RuvA domain 2-like
View Download 0.231 0.966 nucleus a.4.1 Homeodomain-like
View Download 0.230 0.966 nucleus d.58.8 Viral DNA-binding domain
View Download 0.228 0.966 nucleus a.157.1 Skp1 dimerisation domain-like
View Download 0.225 0.966 nucleus a.60.3 C-terminal domain of RNA polymerase alpha subunit
View Download 0.225 0.966 nucleus a.4.5 "Winged helix" DNA-binding domain
View Download 0.225 0.966 nucleus a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.223 0.966 nucleus a.4.5 "Winged helix" DNA-binding domain
View Download 0.223 0.966 nucleus a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.219 0.966 nucleus a.2.10 Epsilon subunit of F1F0-ATP synthase C-terminal domain
View Download 0.219 0.966 nucleus a.4.5 "Winged helix" DNA-binding domain
View Download 0.217 0.966 nucleus d.58.17 Metal-binding domain
View Download 0.216 0.966 nucleus a.60.9 lambda integrase-like, N-terminal domain
View Download 0.216 0.966 nucleus a.159.2 FF domain
View Download 0.215 0.966 nucleus a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.213 0.966 nucleus a.126.1 Serum albumin-like
View Download 0.211 0.966 nucleus d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.211 0.966 nucleus a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.210 0.966 nucleus a.60.3 C-terminal domain of RNA polymerase alpha subunit
View Download 0.208 0.966 nucleus g.57.1 Serine proteinase inhibitor lekti
View Download 0.205 0.966 nucleus a.4.1 Homeodomain-like
View Download 0.205 0.966 nucleus a.4.5 "Winged helix" DNA-binding domain
View Download 0.204 0.966 nucleus a.4.5 "Winged helix" DNA-binding domain
View Download 0.201 0.966 nucleus a.118.8 TPR-like
View Download 0.201 0.966 nucleus a.60.1 SAM/Pointed domain


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle