YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|50120757, gi\|...
Organism:	Pectobacterium atrosepticum SCRI1043
Length:	276 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|50120757, gi|....

Description	E-value	Query Range	Subject Range
gi\|238728942, gi... - gi\|77980020\|ref\|ZP_00835435.1\| COG0846: NAD-dependent protein deacetylases, SIR2 family [Yersinia in...	310.0	[0..1]	[269..1]
NPD_YERPS - NAD-dependent deacetylase OS=Yersinia pseudotuberculosis GN=cobB PE=3 SV=1 gi\|45436432, gi\|... - gi\|45441571\|ref\|NP_993110.1\| NAD-dependent deacetylase [Yersinia pestis biovar Microtus str. 91001],... gi\|22125684, gi\|... - gi\|22125684\|ref\|NP_669107.1\| NAD-dependent deacetylase [Yersinia pestis KIM], gi\|21958598\|gb\|AAM8535... gi\|15979668, gi\|... - gi\|218928766\|ref\|YP_002346641.1\| NAD-dependent deacetylase [Yersinia pestis CO92], gi\|16121898\|ref\|N... gi\|167469314 - gi\|167469314\|ref\|ZP_02334018.1\| hypothetical protein YpesF_15819 [Yersinia pestis FV-1] gi\|51596760, gi\|... - gi\|51596760\|ref\|YP_070951.1\| NAD-dependent deacetylase [Yersinia pseudotuberculosis IP 32953], gi\|51... gi\|186895828, gi... - gi\|186895828\|ref\|YP_001872940.1\| NAD-dependent deacetylase [Yersinia pseudotuberculosis PB1/+], gi\|1... gi\|165925459, gi... - gi\|165925459\|ref\|ZP_02221291.1\| NAD-dependent deacetylase homolog [Yersinia pestis biovar Orientalis... gi\|165938475, gi... - gi\|165938475\|ref\|ZP_02227032.1\| NAD-dependent deacetylase homolog [Yersinia pestis biovar Orientalis... gi\|166008091, gi... - gi\|166008091\|ref\|ZP_02228989.1\| NAD-dependent deacetylase homolog [Yersinia pestis biovar Antiqua st... gi\|108779802, gi... - gi\|108807889\|ref\|YP_651805.1\| NAD-dependent deacetylase [Yersinia pestis Antiqua], gi\|108779802\|gb\|A... gi\|167054699, gi... - gi\|167426344\|ref\|ZP_02318097.1\| NAD-dependent deacetylase homolog [Yersinia pestis biovar Mediaevali... gi\|149290780, gi... - gi\|149366406\|ref\|ZP_01888440.1\| putative Sir2 family protein [Yersinia pestis CA88-4125], gi\|1492907... gi\|145599100, gi... - gi\|145599100\|ref\|YP_001163176.1\| NAD-dependent deacetylase [Yersinia pestis Pestoides F], gi\|1452107... gi\|162353020, gi... - gi\|162420205\|ref\|YP_001607241.1\| NAD-dependent deacetylase [Yersinia pestis Angola], gi\|162353020\|gb... NPD_YERPE - NAD-dependent deacetylase OS=Yersinia pestis GN=cobB PE=3 SV=1 gi\|229689342, gi... - gi\|229843734\|ref\|ZP_04463877.1\| deacetylase of acetyl-CoA synthetase, NAD-dependent [Yersinia pestis... gi\|229894477, gi... - gi\|229894477\|ref\|ZP_04509659.1\| deacetylase of acetyl-CoA synthetase, NAD-dependent [Yersinia pestis... gi\|229694080, gi... - gi\|229841617\|ref\|ZP_04461775.1\| deacetylase of acetyl-CoA synthetase, NAD-dependent [Yersinia pestis... gi\|108775811, gi... - gi\|229902484\|ref\|ZP_04517603.1\| deacetylase of acetyl-CoA synthetase, NAD-dependent [Yersinia pestis... gi\|294504172\|ref... - NAD-dependent deacetylase [Yersinia pestis Z176003]	307.0	[0..1]	[269..1]
gi\|77956323 - gi\|77956323\|ref\|ZP_00820434.1\| COG0846: NAD-dependent protein deacetylases, SIR2 family [Yersinia be...	305.0	[0..1]	[269..1]
gi\|253773856, gi... - gi\|254288035\|ref\|YP_003053783.1\| NAD-dependent deacetylase [Escherichia coli BL21(DE3)], gi\|25397734... gi\|16129083\|ref\|... - NAD-dependent deacetylase [Escherichia coli K12], deacetylase of acetyl-CoA synthetase, NAD-dependen... gi\|83584887, gi\|... - gi\|83584887\|ref\|ZP_00923545.1\| COG0846: NAD-dependent protein deacetylases, SIR2 family [Escherichia... gi\|251784650, gi... - gi\|251784650\|ref\|YP_002998954.1\| hypothetical protein B21_01126 [Escherichia coli BL21], gi\|24237692... gi\|4062692, gi\|8... - gi\|89107966\|ref\|AP_001746.1\| deacetylase of acetyl-CoA synthetase, NAD-dependent [Escherichia coli s... gi\|238860741, gi... - gi\|238900374\|ref\|YP_002926170.1\| deacetylase of acetyl-CoA synthetase, NAD-dependent [Escherichia co... gi\|75511391, gi\|... - gi\|75511391\|ref\|ZP_00734074.1\| COG0846: NAD-dependent protein deacetylases, SIR2 family [Escherichia... gi\|4062692, gi\|1... - gi\|4062692\|dbj\|BAA35940.1\| deacetylase of acetyl-CoA synthetase, NAD-dependent [Escherichia coli W31... gi\|124499575, gi... - gi\|124529867\|ref\|ZP_01700711.1\| Silent information regulator protein Sir2 [Escherichia coli B], gi\|1... gi\|169755413, gi... - gi\|170020485\|ref\|YP_001725439.1\| NAD-dependent deacetylase [Escherichia coli ATCC 8739], gi\|16975541... gi\|170080771, gi... - gi\|170080771\|ref\|YP_001730091.1\| deacetylase of acetyl-CoA synthetase, NAD-dependent [Escherichia co... gi\|157160646, gi... - gi\|75195303\|ref\|ZP_00705373.1\| COG0846: NAD-dependent protein deacetylases, SIR2 family [Escherichia... NPD_ECOLI - NAD-dependent deacetylase (EC 3.5.1.-) (Regulatory protein SIR2 homolog) - Escherichia coli gi\|256023182\|ref... - NAD-dependent deacetylase [Escherichia sp. 4_1_40B] gi\|254161227, gi... - gi\|254161227\|ref\|YP_003044335.1\| NAD-dependent deacetylase [Escherichia coli B str. REL606], gi\|2539...	303.0	[0..2]	[272..4]
gi\|18977526, gi\|... - gi\|18977526\|ref\|NP_578883.1\| NAD-dependent deacetylase [Pyrococcus furiosus DSM 3638], gi\|18893233\|g...	303.0	[0..13]	[267..34]
gi\|24051417, gi\|... - gi\|24112525\|ref\|NP_707035.1\| NAD-dependent deacetylase [Shigella flexneri 2a str. 301], gi\|24051417\|... NPD_SHIFL - NAD-dependent deacetylase OS=Shigella flexneri GN=cobB PE=3 SV=1 gi\|30062653, gi\|... - gi\|30062653\|ref\|NP_836824.1\| NAD-dependent deacetylase [Shigella flexneri 2a str. 2457T], gi\|3004090... gi\|110614682, gi... - gi\|110805134\|ref\|YP_688654.1\| NAD-dependent deacetylase [Shigella flexneri 5 str. 8401], gi\|11061468...	303.0	[0..2]	[271..4]
NPD2_PYRAE - NAD-dependent deacetylase 2 OS=Pyrobaculum aerophilum GN=npdA2 PE=3 SV=1 NPD2_PYRAE - NAD-dependent protein deacylase 2 OS=Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JC...	302.0	[0..31]	[273..3]
gi\|36786133, gi\|... - gi\|37526701\|ref\|NP_930045.1\| NAD-dependent deacetylase [Photorhabdus luminescens subsp. laumondii TT...	301.0	[0..12]	[272..15]
gi\|75239618, gi\|... - gi\|75239618\|ref\|ZP_00723585.1\| COG0846: NAD-dependent protein deacetylases, SIR2 family [Escherichia... gi\|115512429, gi... - gi\|117623305\|ref\|YP_852218.1\| NAD-dependent deacetylase [Escherichia coli APEC O1], gi\|115512429\|gb\|... gi\|215264403, gi... - gi\|215486331\|ref\|YP_002328762.1\| NAD-dependent deacetylase [Escherichia coli O127:H6 str. E2348/69],... gi\|218689072, gi... - gi\|218689072\|ref\|YP_002397284.1\| NAD-dependent deacetylase [Escherichia coli ED1a], gi\|218426636\|emb... gi\|218364770, gi... - gi\|218558001\|ref\|YP_002390914.1\| NAD-dependent deacetylase [Escherichia coli S88], gi\|218364770\|emb\|... NPD_ECOL6 - NAD-dependent deacetylase OS=Escherichia coli O6 GN=cobB PE=3 SV=1 gi\|227886523, gi... - gi\|227886523\|ref\|ZP_04004328.1\| NAD-dependent deacetylase [Escherichia coli 83972], gi\|227836727\|gb\|... gi\|110641296, gi... - gi\|110641296\|ref\|YP_669026.1\| NAD-dependent deacetylase [Escherichia coli 536], gi\|110342888\|gb\|ABG6... gi\|237706894, gi... - gi\|237706894\|ref\|ZP_04537375.1\| NAD-dependent deacetylase [Escherichia sp. 3_2_53FAA], gi\|226898104\|... gi\|91071849, gi\|... - gi\|91210275\|ref\|YP_540261.1\| NAD-dependent deacetylase [Escherichia coli UTI89], gi\|91071849\|gb\|ABE0... gi\|26247264, gi\|... - gi\|26247264\|ref\|NP_753304.1\| NAD-dependent deacetylase [Escherichia coli CFT073], gi\|26107665\|gb\|AAN...	301.0	[0..2]	[268..4]
gi\|12514670, gi\|... - gi\|15801237\|ref\|NP_287254.1\| NAD-dependent deacetylase [Escherichia coli O157:H7 EDL933], gi\|1251467... gi\|260854603\|ref... - deacetylase of acetyl-CoA synthetase, NAD-dependent [Escherichia coli O26:H11 str. 11368] gi\|209772938, gi... - pir\|\|F85675 hypothetical protein cobB [imported] - Escherichia coli (strain O157:H7, substrain EDL9... gi\|293414413\|ref... - NAD-dependent deacetylase [Escherichia coli B185] gi\|261226976\|ref... - NAD-dependent deacetylase [Escherichia coli O157:H7 str. FRIK2000] gi\|291282140\|ref... - NAD-dependent deacetylase [Escherichia coli O55:H7 str. CB9615] gi\|13360962, gi\|... - gi\|15830752\|ref\|NP_309525.1\| NAD-dependent deacetylase [Escherichia coli O157:H7 str. Sakai], gi\|133... gi\|256018624\|ref... - NAD-dependent deacetylase [Shigella sp. D9] gi\|168757835, gi... - gi\|189355231\|gb\|EDU73650.1\| NAD-dependent deacetylase [Escherichia coli O157:H7 str. EC4401], gi\|168... gi\|254792503, gi... - gi\|254792503\|ref\|YP_003077340.1\| deacetylase of acetyl-CoA synthetase, NAD-dependent [Escherichia co... gi\|188014637, gi... - gi\|188014637\|gb\|EDU52759.1\| NAD-dependent deacetylase [Escherichia coli O157:H7 str. EC4113], gi\|168... gi\|189359873, gi... - gi\|189359873\|gb\|EDU78292.1\| NAD-dependent deacetylase [Escherichia coli O157:H7 str. EC4486], gi\|168... gi\|189365429, gi... - gi\|189365429\|gb\|EDU83845.1\| NAD-dependent deacetylase [Escherichia coli O157:H7 str. EC4501], gi\|168... gi\|260843360\|ref... - deacetylase of acetyl-CoA synthetase, NAD-dependent [Escherichia coli O103:H2 str. 12009] gi\|168783490, gi... - gi\|188999150\|gb\|EDU68136.1\| NAD-dependent deacetylase [Escherichia coli O157:H7 str. EC4076], gi\|168... gi\|187767858, gi... - gi\|187767858\|gb\|EDU31702.1\| NAD-dependent deacetylase [Escherichia coli O157:H7 str. EC4196], gi\|168... gi\|189377225, gi... - gi\|189377225\|gb\|EDU95641.1\| NAD-dependent deacetylase [Escherichia coli O157:H7 str. EC508], gi\|1688... gi\|293409486\|ref... - conserved hypothetical protein [Escherichia coli B354] gi\|189370394, gi... - gi\|189370394\|gb\|EDU88810.1\| NAD-dependent deacetylase [Escherichia coli O157:H7 str. EC869], gi\|1687... gi\|82544412, gi\|... - gi\|82544412\|ref\|YP_408359.1\| NAD-dependent deacetylase [Shigella boydii Sb227], gi\|81245823\|gb\|ABB66... NPD_ECO57 - NAD-dependent deacetylase OS=Escherichia coli O157:H7 GN=cobB PE=3 SV=1 gi\|75190177 - gi\|75190177\|ref\|ZP_00703444.1\| COG0846: NAD-dependent protein deacetylases, SIR2 family [Escherichia... gi\|218351385, gi... - gi\|218694653\|ref\|YP_002402320.1\| NAD-dependent deacetylase [Escherichia coli 55989], gi\|218351385\|em... gi\|75208953, gi\|... - gi\|75208953\|ref\|ZP_00709223.1\| COG0846: NAD-dependent protein deacetylases, SIR2 family [Escherichia... gi\|218553697, gi... - gi\|218553697\|ref\|YP_002386610.1\| NAD-dependent deacetylase [Escherichia coli IAI1], gi\|218360465\|emb... gi\|194418119, gi... - gi\|83569557\|ref\|ZP_00921009.1\| COG0846: NAD-dependent protein deacetylases, SIR2 family [Shigella dy... gi\|218370364, gi... - gi\|218700378\|ref\|YP_002408007.1\| NAD-dependent deacetylase [Escherichia coli IAI39], gi\|218370364\|em... gi\|193066282, gi... - gi\|75255635\|ref\|ZP_00727414.1\| COG0846: NAD-dependent protein deacetylases, SIR2 family [Escherichia... gi\|73855158, gi\|... - gi\|74311681\|ref\|YP_310100.1\| NAD-dependent deacetylase [Shigella sonnei Ss046], gi\|73855158\|gb\|AAZ87... gi\|190901381, gi... - gi\|75228209\|ref\|ZP_00714868.1\| COG0846: NAD-dependent protein deacetylases, SIR2 family [Escherichia... gi\|261256210\|ref... - NAD-dependent deacetylase [Escherichia coli O157:H7 str. FRIK966] gi\|75234229, gi\|... - gi\|75234229\|ref\|ZP_00718622.1\| COG0846: NAD-dependent protein deacetylases, SIR2 family [Escherichia... gi\|195938879 - gi\|195938879\|ref\|ZP_03084261.1\| NAD-dependent deacetylase [Escherichia coli O157:H7 str. EC4024] gi\|170683527, gi... - gi\|170683527\|ref\|YP_001744058.1\| NAD-dependent deacetylase [Escherichia coli SMS-3-5], gi\|170521245\|... gi\|208731481, gi... - gi\|208814833\|ref\|ZP_03256012.1\| NAD-dependent deacetylase [Escherichia coli O157:H7 str. EC4045], gi... gi\|208728860, gi... - gi\|208809059\|ref\|ZP_03251396.1\| NAD-dependent deacetylase [Escherichia coli O157:H7 str. EC4206], gi... gi\|209397898, gi... - gi\|209397898\|ref\|YP_002269965.1\| NAD-dependent deacetylase [Escherichia coli O157:H7 str. EC4115], g... gi\|208737689, gi... - gi\|208822204\|ref\|ZP_03262523.1\| NAD-dependent deacetylase [Escherichia coli O157:H7 str. EC4042], gi... gi\|217318505, gi... - gi\|217328078\|ref\|ZP_03444160.1\| NAD-dependent deacetylase [Escherichia coli O157:H7 str. TW14588], g... gi\|209918376, gi... - gi\|209918376\|ref\|YP_002292460.1\| NAD-dependent deacetylase [Escherichia coli SE11], gi\|209911635\|dbj... gi\|260867482\|ref... - deacetylase of acetyl-CoA synthetase, NAD-dependent [Escherichia coli O111:H- str. 11128]	301.0	[0..2]	[268..4]

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Predicted Domain #1

Region A:
Residues: [1-276]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYTRQRLGRF HKGKRMRQQR LRARIFHRDY LAASEVKKPR VVVLTGAGIS AESGIRTFRA  60
   61 ADGLWEEHRV EDVATPEGFQ RNPELVQEFY NARRRQLQQP EIVPNAAHLA LANLEAMLED 120
  121 NFQLITQNID NLHERAGSQR VIHMHGELLK IRCSQSGQIF EWRDDLAVGE RCHCCQFPAP 180
  181 LRPHIVWFGE MPLHMDKIYH ALSQADYFIA IGTSGHVYPA AGFVHEAHSH GAYTLELNLE 240
  241 PSQVESQFDE KIYGPASTVV PEFVSAWLTR GKSITF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	78.0
Match:	1s5pA
Description:	Structure and substrate binding properties of cobB, a Sir2 homolog protein deacetylase from Eschericia coli.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	1.35219834199205	bayes_pls_golite062009
catalytic activity	1.1096503360938	bayes_pls_golite062009
nucleic acid binding	0.798062126041325	bayes_pls_golite062009
DNA binding	0.76914567174665	bayes_pls_golite062009
binding	0.725903081591757	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	0.59989665970892	bayes_pls_golite062009
NAD-dependent histone deacetylase activity	0.5748958272185	bayes_pls_golite062009
NAD-dependent protein deacetylase activity	0.5748958272185	bayes_pls_golite062009
histone deacetylase activity	0.417995543117071	bayes_pls_golite062009
protein deacetylase activity	0.40196400477198	bayes_pls_golite062009
deacetylase activity	0.154033944993939	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: