YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|29140750, gi\|...
Organism:	Salmonella enterica subsp. enterica serovar Typhi str. Ty2
Length:	475 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|29140750, gi|....

Description	E-value	Query Range	Subject Range
gi\|62126412, gi\|... - gi\|62178779\|ref\|YP_215196.1\| serine endoprotease [Salmonella enterica subsp. enterica serovar Choler...	0.0	[1..475]	[4..478]
gi\|168263926, gi... - gi\|205347433\|gb\|EDZ34064.1\| protease Do [Salmonella enterica subsp. enterica serovar Hadar str. RI_0... gi\|168464230, gi... - gi\|195632563\|gb\|EDX51017.1\| protease Do [Salmonella enterica subsp. enterica serovar Newport str. SL... gi\|194450352, gi... - gi\|194450352\|ref\|YP_002044199.1\| serine endoprotease [Salmonella enterica subsp. enterica serovar He... gi\|194470491, gi... - gi\|194470491\|ref\|ZP_03076475.1\| protease Do [Salmonella enterica subsp. enterica serovar Kentucky st... gi\|205331307, gi... - gi\|205331307\|gb\|EDZ18071.1\| protease Do [Salmonella enterica subsp. enterica serovar 4,[5],12:i:- st... DEGP_SALTY - Periplasmic serine endoprotease DegP OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)... gi\|168230515, gi... - gi\|205335030\|gb\|EDZ21794.1\| protease Do [Salmonella enterica subsp. enterica serovar Kentucky str. C... DEGP_SALTY - Periplasmic serine endoprotease DegP OS=Salmonella typhimurium GN=degP PE=3 SV=1 gi\|168234985, gi... - gi\|197291665\|gb\|EDY31015.1\| protease Do [Salmonella enterica subsp. enterica serovar Schwarzengrund ... gi\|168245062, gi... - gi\|205336160\|gb\|EDZ22924.1\| protease Do [Salmonella enterica subsp. enterica serovar Heidelberg str.... gi\|238911275 - gi\|238911275\|ref\|ZP_04655112.1\| serine endoprotease [Salmonella enterica subsp. enterica serovar Ten... gi\|161361941, gi... - gi\|161612577\|ref\|YP_001586542.1\| serine endoprotease [Salmonella enterica subsp. enterica serovar Pa... gi\|167550586, gi... - gi\|205324436\|gb\|EDZ12275.1\| protease Do [Salmonella enterica subsp. enterica serovar Saintpaul str. ... lcl\|NC_016856.1_... - [gene=htrA] [protein=serine endoprotease] [protein_id=YP_005235880.1] [location=245196..246623] gi\|56412482, gi\|... - gi\|56412482\|ref\|YP_149557.1\| serine endoprotease [Salmonella enterica subsp. enterica serovar Paraty... DEGP_SALTY - Protease do OS=Salmonella typhimurium GN=degP PE=2 SV=1 gi\|199605795, gi... - gi\|200388697\|ref\|ZP_03215309.1\| protease Do [Salmonella enterica subsp. enterica serovar Virchow str... gi\|204926696, gi... - gi\|204926696\|ref\|ZP_03217898.1\| protease Do [Salmonella enterica subsp. enterica serovar Javiana str... gi\|205271327, gi... - gi\|205351546\|ref\|YP_002225347.1\| serine endoprotease [Salmonella enterica subsp. enterica serovar Ga... gi\|206707528, gi... - gi\|207855725\|ref\|YP_002242376.1\| serine endoprotease [Salmonella enterica subsp. enterica serovar En... gi\|194712147, gi... - gi\|194736645\|ref\|YP_002113231.1\| protease Do [Salmonella enterica subsp. enterica serovar Schwarzeng... gi\|197265721, gi... - gi\|197265721\|ref\|ZP_03165795.1\| protease Do [Salmonella enterica subsp. enterica serovar Saintpaul s... gi\|197361417, gi... - gi\|197361417\|ref\|YP_002141053.1\| serine endoprotease [Salmonella enterica subsp. enterica serovar Pa... gi\|197940718, gi... - gi\|198246202\|ref\|YP_002214169.1\| protease Do [Salmonella enterica subsp. enterica serovar Dublin str...	2.0E-95	[1..475]	[1..475]
EG10463 - serine endoprotease (protease Do), membrane-associated / Periplasmic, membrane-associated serine end... gi\|238863539, gi... - gi\|238899560\|ref\|YP_002925356.1\| serine endoprotease (protease Do), membrane-associated [Escherichia... gi\|253976391, gi... - gi\|254287084\|ref\|YP_003052832.1\| serine endoprotease (protease Do), membrane-associated [Escherichia... gi\|226840687, gi... - gi\|254037581\|ref\|ZP_04871658.1\| serine endoprotease [Escherichia sp. 1_1_43], gi\|226840687\|gb\|EEH726... DEGP_ECO57 - Periplasmic serine endoprotease DegP OS=Escherichia coli O157:H7 GN=degP PE=3 SV=1 gi\|254160281, gi... - gi\|254160281\|ref\|YP_003043389.1\| serine endoprotease (protease Do), membrane-associated [Escherichia... EG10463 - serine endoprotease (protease Do), membrane-associated / Periplasmic, membrane-associated serine end... gi\|189365646, gi... - gi\|189365646\|gb\|EDU84062.1\| protease Do [Escherichia coli O157:H7 str. EC4501], gi\|168764331\|ref\|ZP_... gi\|188487913, gi... - gi\|75512174\|ref\|ZP_00734746.1\| COG0265: Trypsin-like serine proteases, typically periplasmic, contai... gi\|170021485, gi... - gi\|170021485\|ref\|YP_001726439.1\| serine endoprotease [Escherichia coli ATCC 8739], gi\|169756413\|gb\|A... gi\|74310782, gi\|... - gi\|74310782\|ref\|YP_309201.1\| serine endoprotease [Shigella sonnei Ss046], gi\|73854259\|gb\|AAZ86966.1\|... gi\|168789271, gi... - gi\|189371084\|gb\|EDU89500.1\| protease Do [Escherichia coli O157:H7 str. EC869], gi\|168789271\|ref\|ZP_0... gi\|75176493, gi\|... - gi\|75176493\|ref\|ZP_00696630.1\| COG0265: Trypsin-like serine proteases, typically periplasmic, contai... gi\|217324151, gi... - gi\|217324151\|ref\|ZP_03440235.1\| protease Do [Escherichia coli O157:H7 str. TW14588], gi\|217320372\|gb... gi\|190903575, gi... - gi\|75230476\|ref\|ZP_00716957.1\| COG0265: Trypsin-like serine proteases, typically periplasmic, contai... gi\|169887633, gi... - gi\|170079798\|ref\|YP_001729118.1\| serine endoprotease (protease Do), membrane-associated [Escherichia... gi\|218430514, gi... - gi\|218703417\|ref\|YP_002410936.1\| serine endoprotease [Escherichia coli UMN026], gi\|218430514\|emb\|CAR... gi\|82542761, gi\|... - gi\|82542761\|ref\|YP_406708.1\| serine endoprotease [Shigella boydii Sb227], gi\|81244172\|gb\|ABB64880.1\|... gi\|15799845, gi\|... - gi\|15799845\|ref\|NP_285857.1\| serine endoprotease [Escherichia coli O157:H7 EDL933], gi\|12512885\|gb\|A... gi\|21239017, gi\|... - gi\|89107042\|ref\|AP_000822.1\| serine endoprotease (protease Do), membrane-associated [Escherichia col... gi\|124529614, gi... - gi\|124529614\|ref\|ZP_01700558.1\| protease Do [Escherichia coli B], gi\|124499770\|gb\|EAY47253.1\| protea... DEGP_ECOLI - Protease do precursor (EC 3.4.21.-) - Escherichia coli gi\|13359621, gi\|... - gi\|15829419\|ref\|NP_308192.1\| serine endoprotease [Escherichia coli O157:H7 str. Sakai], gi\|13359621\|... gi\|194418374, gi... - gi\|83569742\|ref\|ZP_00921192.1\| COG0265: Trypsin-like serine proteases, typically periplasmic, contai... gi\|194439111, gi... - gi\|83585478\|ref\|ZP_00924123.1\| COG0265: Trypsin-like serine proteases, typically periplasmic, contai...	2.0E-92	[1..475]	[1..474]
gi\|227884924, gi... - gi\|227884924\|ref\|ZP_04002729.1\| serine endoprotease [Escherichia coli 83972], gi\|227838062\|gb\|EEJ485... gi\|218363873, gi... - gi\|218557104\|ref\|YP_002390017.1\| serine endoprotease [Escherichia coli S88], gi\|218363873\|emb\|CAR015... gi\|218425602, gi... - gi\|218688038\|ref\|YP_002396250.1\| serine endoprotease [Escherichia coli ED1a], gi\|218425602\|emb\|CAR06... gi\|115511572, gi... - gi\|117622448\|ref\|YP_851361.1\| serine endoprotease [Escherichia coli APEC O1], gi\|115511572\|gb\|ABI996... gi\|215263396, gi... - gi\|215485324\|ref\|YP_002327755.1\| serine endoprotease [Escherichia coli O127:H6 str. E2348/69], gi\|21... gi\|237704322, gi... - gi\|237704322\|ref\|ZP_04534803.1\| serine endoprotease [Escherichia sp. 3_2_53FAA], gi\|226902234\|gb\|EEH... gi\|26106505, gi\|... - gi\|26246108\|ref\|NP_752147.1\| serine endoprotease [Escherichia coli CFT073], gi\|26106505\|gb\|AAN78691.... gi\|91070806, gi\|... - gi\|91209232\|ref\|YP_539218.1\| serine endoprotease [Escherichia coli UTI89], gi\|91070806\|gb\|ABE05687.1...	3.0E-92	[1..475]	[1..474]
gi\|110640382, gi... - gi\|110640382\|ref\|YP_668110.1\| serine endoprotease [Escherichia coli 536], gi\|110341974\|gb\|ABG68211.1... gi\|218698582, gi... - gi\|218698582\|ref\|YP_002406211.1\| serine endoprotease [Escherichia coli IAI39], gi\|218368568\|emb\|CAR1... gi\|190906963, gi... - gi\|75240248\|ref\|ZP_00724195.1\| COG0265: Trypsin-like serine proteases, typically periplasmic, contai... gi\|170680398, gi... - gi\|170680398\|ref\|YP_001742290.1\| protease Do [Escherichia coli SMS-3-5], gi\|170518116\|gb\|ACB16294.1\|...	3.0E-92	[1..475]	[1..474]
gi\|193063170, gi... - gi\|75258848\|ref\|ZP_00730238.1\| COG0265: Trypsin-like serine proteases, typically periplasmic, contai... gi\|218552742, gi... - gi\|218552742\|ref\|YP_002385655.1\| serine endoprotease [Escherichia coli IAI1], gi\|218359510\|emb\|CAQ97... gi\|193067748, gi... - gi\|75238866\|ref\|ZP_00722848.1\| COG0265: Trypsin-like serine proteases, typically periplasmic, contai... gi\|218693627, gi... - gi\|218693627\|ref\|YP_002401294.1\| serine endoprotease [Escherichia coli 55989], gi\|218350359\|emb\|CAU9... gi\|194413698, gi... - gi\|75210486\|ref\|ZP_00710637.1\| COG0265: Trypsin-like serine proteases, typically periplasmic, contai... gi\|75194373, gi\|... - gi\|75194373\|ref\|ZP_00704443.1\| COG0265: Trypsin-like serine proteases, typically periplasmic, contai... gi\|209917353, gi... - gi\|209917353\|ref\|YP_002291437.1\| serine endoprotease [Escherichia coli SE11], gi\|209910612\|dbj\|BAG75... gi\|75189258, gi\|... - gi\|75189258\|ref\|ZP_00702525.1\| COG0265: Trypsin-like serine proteases, typically periplasmic, contai...	3.0E-92	[1..475]	[1..474]
gi\|74474903 - gi\|74474903\|dbj\|BAE44436.1\| antigenic protein Et 49 [Edwardsiella tarda]	4.0E-92	[1..475]	[1..471]
gi\|110804216, gi... - gi\|110804216\|ref\|YP_687736.1\| serine endoprotease [Shigella flexneri 5 str. 8401], gi\|110613764\|gb\|A... gi\|30039963, gi\|... - gi\|30061721\|ref\|NP_835892.1\| serine endoprotease [Shigella flexneri 2a str. 2457T], gi\|30039963\|gb\|A... gi\|24050365, gi\|... - gi\|24111599\|ref\|NP_706109.1\| serine endoprotease [Shigella flexneri 2a str. 301], gi\|24050365\|gb\|AAN...	6.0E-92	[1..475]	[1..474]
gi\|81239700, gi\|... - gi\|82775552\|ref\|YP_401899.1\| serine endoprotease [Shigella dysenteriae Sd197], gi\|81239700\|gb\|ABB604...	7.0E-92	[1..475]	[1..474]
gi\|36787309, gi\|... - gi\|37527873\|ref\|NP_931218.1\| protease precursor DegQ [Photorhabdus luminescens subsp. laumondii TTO1...	1.0E-91	[1..475]	[1..457]

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Predicted Domain #1

Region A:
Residues: [1-475]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKKTTLAMSA LALSLGLALS PLSATAAETS SSAMTAQQMP SLAPMLEKVM PSVVSINVEG  60
   61 STTVNTPRMP RNFQQFFGDD SPFCQDGSPF QNSPFCQGGG NGGNGGQQQK FMALGSGVII 120
  121 DAAKGYVVTN NHVVDNASVI KVQLSDGRKF DAKVVGKDPR SDIALIQIQN PKNLTAIKLA 180
  181 DSDALRVGDY TVAIGNPFGL GETVTSGIVS ALGRSGLNVE NYENFIQTDA AINRGNSGGA 240
  241 LVNLNGELIG INTAILAPDG GNIGIGFAIP SNMVKNLTSQ MVEYGQVKRG ELGIMGTELS 300
  301 SELAKAMKVD AQRGAFVSQV MPNSSAAKAG IKAGDVITSL NGKPISSFAA LRAQVGTMPV 360
  361 GSKISLGLLR EGKAITVNLE LQQSSQSQVD SSTIFSGIEG AEMSNKGQDK GVVVSSVKAN 420
  421 SPAAQIGLKK GDVIIGANQQ PVKNIAELRK ILDSKPSVLA LNIQRGDSSI YLLMQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	92.0
Match:	1ky9A
Description:	Protease Do (DegP, HtrA), C-terminal domains; Protease Do (DegP, HtrA), catalytic domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein binding	2.10639523340529	bayes_pls_golite062009
hydrolase activity	1.95262287761731	bayes_pls_golite062009
binding	1.92577219161709	bayes_pls_golite062009
peptidase activity	0.892956033345508	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	0.644798716305534	bayes_pls_golite062009
endopeptidase activity	0.323781287331288	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: