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View Structure Prediction Details

Protein: RIPK1
Organism: Homo sapiens
Length: 671 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RIPK1.

Description E-value Query
Range
Subject
Range
gi|3426027, gi|7... - sp|Q13546|RIK1_HUMAN Receptor-interacting serine/threonine-protein kinase 2 (Serine/threonine-protei...
0.0 [1..671] [1..671]
gi|114605229, gi... - gi|114605231|ref|XP_001161146.1| PREDICTED: receptor (TNFRSF)-interacting serine-threonine kinase 1 ...
0.0 [1..671] [171..841]
gi|109069441 - gi|109069441|ref|XP_001091986.1| PREDICTED: similar to receptor (TNFRSF)-interacting serine-threonin...
0.0 [1..671] [1..671]
gi|149045237, gi... - gi|157824041|ref|NP_001100820.1| receptor (TNFRSF)-interacting serine-threonine kinase 1 [Rattus nor...
0.0 [1..671] [1..658]
RIPK1_MOUSE - Receptor-interacting serine/threonine-protein kinase 1 OS=Mus musculus GN=Ripk1 PE=1 SV=1
0.0 [1..671] [1..656]
gi|67970349 - gi|67970349|dbj|BAE01517.1| unnamed protein product [Macaca fascicularis]
0.0 [66..671] [1..606]
gi|78042490, gi|... - gi|78042490|ref|NP_001030184.1| receptor (TNFRSF)-interacting serine-threonine kinase 1 [Bos taurus]...
0.0 [5..671] [1..665]

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Predicted Domain #1
Region A:
Residues: [1-360]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQPDMSLNVI KMKSSDFLES AELDSGGFGK VSLCFHRTQG LMIMKTVYKG PNCIEHNEAL  60
   61 LEEAKMMNRL RHSRVVKLLG VIIEEGKYSL VMEYMEKGNL MHVLKAEMST PLSVKGRIIL 120
  121 EIIEGMCYLH GKGVIHKDLK PENILVDNDF HIKIADLGLA SFKMWSKLNN EEHNELREVD 180
  181 GTAKKNGGTL YYMAPEHLND VNAKPTEKSD VYSFAVVLWA IFANKEPYEN AICEQQLIMC 240
  241 IKSGNRPDVD DITEYCPREI ISLMKLCWEA NPEARPTFPG IEEKFRPFYL SQLEESVEED 300
  301 VKSLKKEYSN ENAVVKRMQS LQLDCVAVPS SRSNSATEQP GSLHSSQGLG MGPVEESWFA 360
  361 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 75.154902
Match: 1zmuA
Description: Catalytic and ubiqutin-associated domains of MARK2/PAR-1: Wild type
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [361-492]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSLEHPQEEN EPSLQSKLQD EANYHLYGSR MDRQTKQQPR QNVAYNREEE RRRRVSHDPF  60
   61 AQQRPYENFQ NTEGKGTAYS SAASHGNAVH QPSGLTSQPQ VLYQNNGLYS SHGFGTRPLD 120
  121 PGTAGPRVWY RP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [493-671]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPSHMPSLHN IPVPETNYLG NTPTMPFSSL PPTDESIKYT IYNSTGIQIG AYNYMEIGGT  60
   61 SSSLLDSTNT NFKEEPAAKY QAIFDNTTSL TDKHLDPIRE NLGKHWKNCA RKLGFTQSQI 120
  121 DEIDHDYERD GLKEKVYQML QKWVMREGIK GATVGKLAQA LHQCSRIDLL SSLIYVSQN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.045757
Match: 1wxpA
Description: Solution structure of the death domain of nuclear matrix protein p84
Matching Structure (courtesy of the PDB):

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