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View Structure Prediction Details

Protein: sv-PE
Organism: Drosophila melanogaster
Length: 794 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for sv-PE.

Description E-value Query
Range
Subject
Range
sv-PF - The gene shaven is referred to in FlyBase by the symbol Dmel\sv (CG11049, FBgn0005561). It is a prot...
491.0 [0..1] [755..1]

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Predicted Domain #1
Region A:
Residues: [1-161]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLIMDIQTST HHIHGLGTHE LQHRILHPHI LHSTQEETLN TSTGQLEHDS QHLQQHHLTH  60
   61 HQQQDVSPTL HNLQNTRTGD SLSTTINTNQ NQHGHQHLSG SNMYTSSQME DKSKANKYDE 120
  121 YSSRTLSNIS DANTTPSANN FITQSQGIEW ITAMNDIQNG A

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [162-373]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EDSHSSQGSI SGDGHGGVNQ LGGVFVNGRP LPDVVRQRIV ELAHNGVRPC DISRQLRVSH  60
   61 GCVSKILSRY YETGSFKAGV IGGSKPKVAT PPVVDAIANY KRENPTMFAW EIRDRLLAEA 120
  121 ICSQDNVPSV SSINRIVRNK AAEKAKHVHH HQQHHVSQSL GGGHIATESV DSSTGTIGEP 180
  181 QPPTSNSSAN SVNTNVSASA SVHASIPTSG TD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 64.045757
Match: 1k78A
Description: Pax-5
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
sequence-specific DNA binding 3.5139760613123 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
transcription activator activity 3.10621734076555 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
protein binding 1.88087411289001 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [374-618]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SVQVSVGHIN ANSNETTHIN STAEQRTTGY SINGILGIQH GHHSHNNNNN SSVNNNNNTE  60
   61 SSCKRKRIEA HDENHDTNIH SDNDDGKRQR MSTYSGDQLY TNIWSGKWCI KDDHKLLAEL 120
  121 GNLTASTGNC PATYYEASNG FSTTPISGSG ATASGNDTSM LYDSITTISQ TQSSIYTPAI 180
  181 GPSIGTGSLT PLVPISMHEM KLSANSIQEQ TVPPFYTALA FDGNYTSMTS LENCSSLVGQ 240
  241 EHIVM

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [619-794]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PESSDSNTLC PISTRIVPDI TETNSTRVKE PLTNSDGCSE DNNKEPEKSN SSQSSDHIAS  60
   61 PHLHHIGEEQ LRGNRRSNLN ASTHPSSLIP LQPSGGSSLL NINPSENRSD VELNLSNNVG 120
  121 LYSTPTVLPS FNHYSAGFLY FQAAAQLYPV QITPTILHIP SMVELTDHMV TALAVA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle