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View Structure Prediction Details

Protein: YIH1
Organism: Saccharomyces cerevisiae
Length: 258 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YIH1.

Description E-value Query
Range
Subject
Range
IMPCT_XENLA - Protein IMPACT OS=Xenopus laevis GN=impact PE=2 SV=1
2.0E-92 [2..258] [6..293]
YIH1 - Protein that inhibits activation of Gcn2p, an eIF2 alpha subunit protein kinase, by competing for Gc...
gi|151943874 - gi|151943874|gb|EDN62174.1| conserved protein [Saccharomyces cerevisiae YJM789]
gi|207347270 - gi|207347270|gb|EDZ73503.1| YCR059Cp-like protein [Saccharomyces cerevisiae AWRI1631]
gi|190406483 - gi|190406483|gb|EDV09750.1| conserved hypothetical protein [Saccharomyces cerevisiae RM11-1a]
YIH1_YEAST - Protein IMPACT homolog OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YIH1 PE=1 SV=1
2.0E-92 [1..258] [1..258]
IMPCT_MOUSE - Protein IMPACT OS=Mus musculus GN=Impact PE=1 SV=2
1.0E-85 [4..256] [8..293]
gi|4996357 - gi|4996357|dbj|BAA78421.1| unnamed protein product [Xenopus borealis]
1.0E-84 [2..258] [3..290]
IMPACT - Impact homolog (mouse)
gi|123992930, gi... - gi|157928552|gb|ABW03572.1| Impact homolog (mouse) [synthetic construct], gi|123992930|gb|ABM84067.1...
3.0E-84 [6..256] [10..294]
YIH1_SCHPO - Protein IMPACT homolog OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=yih1 PE=3 SV=1
SPAC27E2.02 - IMPACT homolog
2.0E-67 [3..252] [2..260]
gi|14973721, gi|... - gi|66878383|ref|ZP_00403866.1| COG1739: Uncharacterized conserved protein [Streptococcus pneumoniae ...
gi|25303433 - pir||C95258 conserved hypothetical protein SP2209 [imported] - Streptococcus pneumoniae (strain TIGR...
1.0E-37 [130..255] [5..126]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
1.0E-37 [138..251] [13..124]

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Predicted Domain #1
Region A:
Residues: [1-108]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDDDHEQLVE ELEAVEAIYP DLLSKKQEDG SIIVVKVPQH EYMTLQISFP THYPSEEAPN  60
   61 VIEVGVCTSL AKRDLYDTKY LQHLFQEVMD SVFHRGSVCL FDFLTELD

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [109-258]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GVLYVEPEEE TEPVQQSDIP TDPFEGWTAS DPITDRGSTF MAFAAHVTSE EQAFAMLDLL  60
   61 KTDSKMRKAN HVMSAWRIKQ DGSAATYQDS DDDGETAAGS RMLHLITIMD VWNVIVVVAR 120
  121 WFGGAHIGPD RFKHINSTAR EAVVRAGFDS 

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 62.853872
Match: PF01205
Description: Uncharacterized protein family UPF0029

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
transferase activity, transferring phosphorus-containing groups 2.55433995647388 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 2.26982378355508 bayes_pls_golite062009
3'-5'-exoribonuclease activity 2.17994566452938 bayes_pls_golite062009
kinase activity 2.16946639423557 bayes_pls_golite062009
structural constituent of ribosome 2.0116317330767 bayes_pls_golite062009
transcription regulator activity 1.90728659801871 bayes_pls_golite062009
structural molecule activity 1.77722756041008 bayes_pls_golite062009
nucleic acid binding 1.75408506104351 bayes_pls_golite062009
DNA binding 1.50208874269692 bayes_pls_golite062009
binding 1.50032731466041 bayes_pls_golite062009
transferase activity 1.25037643378444 bayes_pls_golite062009
catalytic activity 0.878454819018611 bayes_pls_golite062009
ribonuclease activity 0.825588323751637 bayes_pls_golite062009
nuclease activity 0.234623495149702 bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters 0.21915720954962 bayes_pls_golite062009
exoribonuclease activity 0.20391251413344 bayes_pls_golite062009
protein binding 0.191135371876197 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle