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View Structure Prediction Details

Protein: YPS3
Organism: Saccharomyces cerevisiae
Length: 508 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YPS3.

Description E-value Query
Range
Subject
Range
YPS3 - Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
YPS3_YEAST - Aspartic proteinase yapsin-3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YPS3 PE=1 S...
gi|151941286 - gi|151941286|gb|EDN59664.1| aspartic protease [Saccharomyces cerevisiae YJM789]
0.0 [1..508] [1..508]
gi|6180007 - gi|6180007|gb|AAF05750.1|AF191336_1 pregnancy-associated glycoprotein-11 [Capra hircus]
0.0 [1..396] [1..379]
PAG1_BOVIN - Pregnancy-associated glycoprotein 1 OS=Bos taurus PE=1 SV=1
0.0 [1..396] [1..379]

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Predicted Domain #1
Region A:
Residues: [1-64]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKLQLAAVAT LAVLTSPAFG RVLPDGKYVK IPFTKKKNGD NGELSKRSNG HEKFVLANEQ  60
   61 SFYS

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [208-244]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DATAYSLFLN DESQSSGSIL FGAVDHSKYE GQLYTIP

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [379-433]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NAYVVYDLDN YEISLAQAKY GTGKENVEVI KSTVPSAIRA PSYNNTWSNY ASATS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 918.68867
Match: 1ypsA_
Description: No description for 1ypsA_ was found.

Predicted functions:

Term Confidence Notes
aspartic-type endopeptidase activity 7.9145950161796 bayes_pls_golite062009
aspartic-type peptidase activity 7.9145950161796 bayes_pls_golite062009
peptidase activity 5.78181196721293 bayes_pls_golite062009
endopeptidase activity 5.4888481808613 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 5.39972232367526 bayes_pls_golite062009
hydrolase activity 4.34796304893506 bayes_pls_golite062009
catalytic activity 1.54514410489082 bayes_pls_golite062009
binding 1.10054369202721 bayes_pls_golite062009
receptor binding 0.561225023505917 bayes_pls_golite062009
protein binding 0.193907750061394 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [65-207]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VELAIGTPSQ NLTVLLDTGS ADLWVPGKGN PYCGSVMDCD QYGVFDKTKS STFKANKSSP  60
   61 FYAAYGDGTY AEGAFGQDKL KYNELDLSGL SFAVANESNS TFGVLGIGLS TLEVTYSGKV 120
  121 AIMDKRSYEY DNFPLFLKHS GAI

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [245-378]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LVNLYKSQGY QHPVAFDVTL QGLGLQTDKR NITLTTTKLP ALLDSGTTLT YLPSQAVALL  60
   61 AKSLNASYSK TLGYYEYTCP SSDNKTSVAF DFGGFRINAP LSDFTMQTSV GTCVLAIIPQ 120
  121 AGNATAILGD SFLR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 918.68867
Match: 1ypsA_
Description: No description for 1ypsA_ was found.

Predicted Domain #3
Region A:
Residues: [434-508]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGNIFTTVRT FNGTSTATTT RSTTTKKTNS TTTAKSTHKS KRALQRAATN SASSIRSTLG  60
   61 LLLVPSLLIL SVFFS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle