YRC Public Data Repository - Protein Structure Prediction

Protein:	VBA1
Organism:	Saccharomyces cerevisiae
Length:	562 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for VBA1.

Description	E-value	Query Range	Subject Range
gi\|21225257, gi\|... - gi\|7649556\|emb\|CAB89031.1\| putative membrane transport protein. [Streptomyces coelicolor A3(2)], gi\|...	3.0E-85	[16..562]	[12..525]
gi\|25498023 - pir\|\|D96902 MDR-type permease [imported] - Clostridium acetobutylicum gi\|15893318, gi\|... - gi\|15893318\|ref\|NP_346667.1\| MDR-type permease [Clostridium acetobutylicum ATCC 824], gi\|15022839\|gb...	6.0E-79	[33..477]	[4..418]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	6.0E-78	[7..556]	[18..530]
lcl\|NC_016856.1_... - [gene=emrB] [protein=putative multidrug transport protein] [protein_id=YP_005238915.1] [location=298... gi\|16766126, gi\|... - gi\|16766126\|ref\|NP_461741.1\| putative multidrug transport protein [Salmonella typhimurium LT2], gi\|1... gi\|167992539, gi... - gi\|205329344\|gb\|EDZ16108.1\| multidrug resistance protein B [Salmonella enterica subsp. enterica sero...	2.0E-75	[32..554]	[9..501]
gi\|16761596 - gi\|16761596\|ref\|NP_457213.1\| multidrug resistance protein B [Salmonella enterica subsp. enterica ser... gi\|25306158, gi\|... - gi\|25306158\|pir\|\|AG0842 multidrug resistance protein B [imported] - Salmonella enterica subsp. enter... gi\|29138709, gi\|... - gi\|29143076\|ref\|NP_806418.1\| multidrug resistance protein B [Salmonella enterica subsp. enterica ser... gi\|213850377 - gi\|213850377\|ref\|ZP_03381275.1\| multidrug resistance protein B [Salmonella enterica subsp. enterica ... gi\|214000013 - gi\|214000013\|ref\|ZP_03410748.1\| multidrug resistance protein B [Salmonella enterica subsp. enterica ...	3.0E-75	[32..554]	[9..501]
gi\|15927932, gi\|... - gi\|15927932\|ref\|NP_375465.1\| hypothetical protein SA2142 [Staphylococcus aureus subsp. aureus N315],... gi\|253314692 - gi\|253314692\|ref\|ZP_04837905.1\| hypothetical protein SauraC_00665 [Staphylococcus aureus subsp. aure... gi\|12003106, gi\|... - pir\|\|C90035 hypothetical protein SA2142 [imported] - Staphylococcus aureus (strain N315), gi\|120031... gi\|255007128 - gi\|255007128\|ref\|ZP_05145729.2\| hypothetical protein SauraM_11685 [Staphylococcus aureus subsp. aure... gi\|14248126, gi\|... - gi\|15925342\|ref\|NP_372876.1\| multidrug resistance protein [Staphylococcus aureus subsp. aureus Mu50]... gi\|269203983\|ref... - EmrB/QacA family drug resistance transporter [Staphylococcus aureus subsp. aureus ED98] gi\|90583610, gi\|... - gi\|90583610\|ref\|ZP_01239364.1\| Drug resistance transporter EmrB/QacA subfamily [Staphylococcus aureu... gi\|147741858, gi... - gi\|90585929\|ref\|ZP_01241634.1\| Drug resistance transporter EmrB/QacA subfamily [Staphylococcus aureu... gi\|156980667, gi... - gi\|156980667\|ref\|YP_001442926.1\| hypothetical protein SAHV_2336 [Staphylococcus aureus subsp. aureus...	1.0E-74	[34..561]	[137..632]
gi\|229896373, gi... - gi\|229896373\|ref\|ZP_04511542.1\| multidrug resistance protein B [Yersinia pestis Pestoides A], gi\|229... gi\|229899449, gi... - gi\|229899449\|ref\|ZP_04514592.1\| multidrug resistance protein B [Yersinia pestis biovar Orientalis st... gi\|165926632, gi... - gi\|165926632\|ref\|ZP_02222464.1\| multidrug resistance protein B [Yersinia pestis biovar Orientalis st... gi\|22124829, gi\|... - gi\|22124829\|ref\|NP_668252.1\| multidrug resistance protein B [Yersinia pestis KIM], gi\|21957657\|gb\|AA... gi\|166213072, gi... - gi\|166213072\|ref\|ZP_02239107.1\| multidrug resistance protein B [Yersinia pestis biovar Antiqua str. ... gi\|25306154 - pir\|\|AB0397 multidrug resistance protein B [imported] - Yersinia pestis (strain CO92) gi\|165990079, gi... - gi\|166011079\|ref\|ZP_02231977.1\| multidrug resistance protein B [Yersinia pestis biovar Antiqua str. ... gi\|51595205, gi\|... - gi\|51595205\|ref\|YP_069396.1\| MFS multidrug efflux pump, emrB subunit [Yersinia pseudotuberculosis IP... gi\|45435371, gi\|... - gi\|45440514\|ref\|NP_992053.1\| multidrug resistance protein B [Yersinia pestis biovar Microtus str. 91... gi\|218930293, gi... - gi\|218930293\|ref\|YP_002348168.1\| multidrug resistance protein B [Yersinia pestis CO92], gi\|16123425\|... gi\|149364891, gi... - gi\|149364891\|ref\|ZP_01886926.1\| multidrug resistance protein B [Yersinia pestis CA88-4125], gi\|14929... gi\|145211859, gi... - gi\|145600163\|ref\|YP_001164239.1\| multidrug resistance protein B [Yersinia pestis Pestoides F], gi\|14... gi\|167421612, gi... - gi\|167421612\|ref\|ZP_02313365.1\| multidrug resistance protein B [Yersinia pestis biovar Orientalis st... gi\|167051986, gi... - gi\|167399482\|ref\|ZP_02305006.1\| multidrug resistance protein B [Yersinia pestis biovar Antiqua str. ... gi\|170025556, gi... - gi\|170025556\|ref\|YP_001722061.1\| EmrB/QacA family drug resistance transporter [Yersinia pseudotuberc... gi\|167057491, gi... - gi\|167423321\|ref\|ZP_02315074.1\| multidrug resistance protein B [Yersinia pestis biovar Mediaevalis s... gi\|162354357, gi... - gi\|77633286\|ref\|ZP_00795425.1\| COG0477: Permeases of the major facilitator superfamily [Yersinia pes... gi\|89103813, gi\|... - gi\|89103813\|ref\|ZP_01176376.1\| COG0477: Permeases of the major facilitator superfamily [Yersinia pes... Q66E38\|Q66E38_YERPS - MFS multidrug efflux pump, emrB subunit - Yersinia pseudotuberculosis gi\|186894223, gi... - gi\|186894223\|ref\|YP_001871335.1\| EmrB/QacA family drug resistance transporter [Yersinia pseudotuberc... gi\|153950510, gi... - gi\|77631828\|ref\|ZP_00794414.1\| COG0477: Permeases of the major facilitator superfamily [Yersinia pse... gi\|108808750, gi... - gi\|108808750\|ref\|YP_652666.1\| multidrug resistance protein B [Yersinia pestis Antiqua], gi\|108780663... gi\|229901211, gi... - gi\|229901211\|ref\|ZP_04516333.1\| multidrug resistance protein B [Yersinia pestis Nepal516], gi\|229681... gi\|229695246, gi... - gi\|229838880\|ref\|ZP_04459039.1\| multidrug resistance protein B [Yersinia pestis biovar Orientalis st...	2.0E-74	[32..554]	[8..500]
gi\|19551627, gi\|... - gi\|62389280\|ref\|YP_224682.1\| major facilitator superfamily permease [Corynebacterium glutamicum ATCC...	5.0E-74	[5..561]	[2..543]
gi\|16944692 - gi\|16944692\|emb\|CAC28808.2\| related to tetracycline efflux protein (otrb) [Neurospora crassa]	3.0E-73	[5..553]	[14..552]

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Predicted Domain #1

Region A:
Residues: [1-212]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQTLDETSNL LPPPEEAEAP PLEQKFHEYN LALPKFPILF SLWLGSFLSS LDSTIVANIM  60
   61 NRVAEEFSES SKKQWIATSF LLTNTAFQPL YGKLSDITGR KSALLTAQFF FGLGCLLTCF 120
  121 ARNVTEFSIA RAICGIGAGG LNAISSIAVS DICTARERGV YQGYANIVFG FGQLLGAPLG 180
  181 GVFIETIGWR ALFGIQVPVI MLCSVLAIKN IN

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [276-423]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ERYYATEKIL PFELLTRSFC LSSAVTVISS FVVFGEIFRS PIYLQLLQNI SVTKTGLFLI  60
   61 FPSISVAVGS LVTGWVLRNT KINLAHCAYQ IIFGGMIMQL LGLGLGYFLL SHLNPDYTIY 120
  121 DMLESITFRS NSIWWKLIYV FASVLVSF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	7.522879
Match:	1ja5A_
Description:	No description for 1ja5A_ was found.

Predicted Domain #2

Region A:
Residues: [213-275]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IKLFHVPPMK ERYTLKNLSR IDIFGSLSLV ATISGVLFLC SSQLNKLYLA LFTIGSFIVF  60
   61 ILV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	7.522879
Match:	1ja5A_
Description:	No description for 1ja5A_ was found.

Predicted Domain #3

Region A:
Residues: [424-562]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GYACLLVATL VSIVFTVEKS QQGTMTGVFY LWRSIGNVLG ASLTLVSYEN SLSSMLWNYM  60
   61 FKTKRDDEYH FTKKQYYSLI NDSSYLRGPN FPTDIFVRIL DVYKKAFLIS YIPNIALAAV 120
  121 GIVLSLYLVK HTYKRSSSS

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits