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View Structure Prediction Details

Protein: PBX1
Organism: Homo sapiens
Length: 430 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PBX1.

Description E-value Query
Range
Subject
Range
gi|74006104 - gi|74006104|ref|XP_545786.2| PREDICTED: similar to Pre-B-cell leukemia transcription factor-1 (Homeo...
1.0E-66 [1..430] [1..430]
gi|8096555, gi|4... - gi|8096555|dbj|BAA96135.1| PBX1A [Gallus gallus], gi|46048897|ref|NP_990077.1| pre-B-cell leukemia t...
1.0E-64 [1..430] [1..430]
gi|109498928 - gi|109498928|ref|XP_001072218.1| PREDICTED: similar to Pre-B-cell leukemia transcription factor 1 (H...
gi|114561079 - gi|114561079|ref|XP_001174513.1| PREDICTED: pre-B-cell leukemia transcription factor 1 isoform 1 [Pa...
2.0E-63 [1..430] [1..422]
gi|114561073 - gi|114561073|ref|XP_001174519.1| PREDICTED: pre-B-cell leukemia transcription factor 1 isoform 2 [Pa...
1.0E-62 [1..430] [1..453]
gi|7160792, gi|2... - gi|7160792|emb|CAB76454.1| Pbx1a homeodomain protein [Danio rerio], gi|42542444|gb|AAH66446.1| Pre-B...
1.0E-60 [1..430] [1..428]
gi|109019313 - gi|109019313|ref|XP_001084131.1| PREDICTED: similar to Pre-B-cell leukemia transcription factor 1 (H...
1.0E-60 [1..430] [1..430]
PBX3 - pre-B-cell leukemia homeobox 3
gi|208967122 - gi|208967122|dbj|BAG73575.1| pre-B-cell leukemia homeobox 3 [synthetic construct]
1.0E-57 [1..430] [1..434]
PBX3_MOUSE - Pre-B-cell leukemia transcription factor 3 OS=Mus musculus GN=Pbx3 PE=2 SV=1
gi|109469599, gi... - gi|157822451|ref|NP_001101304.1| pre-B-cell leukemia homeobox 3 [Rattus norvegicus], gi|149038956|gb...
2.0E-57 [1..430] [1..434]

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Predicted Domain #1
Region A:
Residues: [1-83]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDEQPRLMHS HAGVGMAGHP GLSQHLQDGA GGTEGEGGRK QDIGDILQQI MTITDQSLDE  60
   61 AQARKHALNC HRMKPALFNV LCE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [84-236]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IKEKTVLSIR GAQEEEPTDP QLMRLDNMLL AEGVAGPEKG GGSAAAAAAA AASGGAGSDN  60
   61 SVEHSDYRAK LSQIRQIYHT ELEKYEQACN EFTTHVMNLL REQSRTRPIS PKEIERMVSI 120
  121 IHRKFSSIQM QLKQSTCEAV MILRSRFLDA RRK

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 0.981
Match: 2h8rA
Description: No description for 2h8rA was found.

Predicted Domain #3
Region A:
Residues: [237-332]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RRNFNKQATE ILNEYFYSHL SNPYPSEEAK EELAKKCGIT VSQVSNWFGN KRIRYKKNIG  60
   61 KFQEEANIYA AKTAVTATNV SAHGSQANSP STPNSA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.30103
Match: 1b72B
Description: pbx1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
sequence-specific DNA binding 3.5139760613123 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
transcription activator activity 3.10621734076555 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
protein binding 1.88087411289001 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.62096064323298 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
transcription coactivator activity 0.2679415219517 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [333-430]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSSSSFNMSN SGDLFMSVQS LNGDSYQGAQ VGANVQSQVD TLRHVISQTG GYSDGLAASQ  60
   61 MYSPQGISAN GGWQDATTPS SVTSPTEGPG SVHSDTSN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle