YRC Public Data Repository - Protein Structure Prediction

Protein:	MMAA
Organism:	Homo sapiens
Length:	418 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MMAA.

Description	E-value	Query Range	Subject Range
gi\|157818293, gi... - gi\|34851579\|ref\|XP_214659.2\| PREDICTED: similar to methylmalonic aciduria type A [Rattus norvegicus]...	2.0E-77	[1..417]	[3..414]
MMAA_MOUSE - Methylmalonic aciduria type A homolog, mitochondrial OS=Mus musculus GN=Mmaa PE=1 SV=1	1.0E-75	[1..417]	[3..414]
gi\|114596301 - gi\|114596301\|ref\|XP_526697.2\| PREDICTED: methylmalonic aciduria type A [Pan troglodytes]	1.0E-74	[1..416]	[1..416]
gi\|72533532 - gi\|72533532\|gb\|AAI01182.1\| MMAA protein [Homo sapiens]	1.0E-72	[1..414]	[1..414]
gi\|73978278 - gi\|73978278\|ref\|XP_539752.2\| PREDICTED: similar to methylmalonic aciduria type A [Canis familiaris]	1.0E-72	[1..418]	[464..882]
gi\|76638353, gi\|... - gi\|76638353\|ref\|XP_869341.1\| PREDICTED: similar to methylmalonic aciduria type A isoform 2 [Bos taur...	9.0E-71	[1..417]	[3..419]
gi\|158140695, gi... - gi\|158320496\|ref\|YP_001513003.1\| signal recognition particle protein [Alkaliphilus oremlandii OhILAs...	1.0E-63	[46..399]	[7..363]
gi\|23098986, gi\|... - gi\|23098986\|ref\|NP_692452.1\| signal recognition particle [Oceanobacillus iheyensis HTE831], gi\|22777...	7.0E-63	[46..401]	[7..363]
gi\|242256579, gi... - gi\|242256579\|ref\|ZP_04801468.1\| signal recognition particle protein [Thermoanaerobacter sp. X513], g... gi\|166854590, gi... - gi\|167040350\|ref\|YP_001663335.1\| signal recognition particle protein [Thermoanaerobacter sp. X514], ...	1.0E-62	[40..395]	[3..356]

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Predicted Domain #1

Region A:
Residues: [1-84]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPMLLPHPHQ HFLKGLLRAP FRCYHFIFHS STHLGSGIPC AQPFNSLGLH CTKWMLLSDG  60
   61 LKRKLCVQTT LKDHTEGLSD KEQR

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [85-418]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FVDKLYTGLI QGQRACLAEA ITLVESTHSR KKELAQVLLQ KVLLYHREQE QSNKGKPLAF  60
   61 RVGLSGPPGA GKSTFIEYFG KMLTERGHKL SVLAVDPSSC TSGGSLLGDK TRMTELSRDM 120
  121 NAYIRPSPTR GTLGGVTRTT NEAILLCEGA GYDIILIETV GVGQSEFAVA DMVDMFVLLL 180
  181 PPAGGDELQG IKRGIIEMAD LVAVTKSDGD LIVPARRIQA EYVSALKLLR KRSQVWKPKV 240
  241 IRISARSGEG ISEMWDKMKD FQDLMLASGE LTAKRRKQQK VWMWNLIQES VLEHFRTHPT 300
  301 VREQIPLLEQ KVLIGALSPG LAADFLLKAF KSRD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	53.154902
Match:	2qm7A
Description:	No description for 2qm7A was found.

Predicted functions:

Term	Confidence	Notes
nucleoside-triphosphatase activity	2.03298441743645	bayes_pls_golite062009
pyrophosphatase activity	1.98617097875287	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	1.96633266544098	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	1.96437252410847	bayes_pls_golite062009
amino acid transmembrane transporter activity	1.59627719545436	bayes_pls_golite062009
transporter activity	1.5835033929282	bayes_pls_golite062009
carboxylic acid transmembrane transporter activity	1.53837763663408	bayes_pls_golite062009
organic acid transmembrane transporter activity	1.53657633349085	bayes_pls_golite062009
ATPase activity	1.44825977402161	bayes_pls_golite062009
transmembrane transporter activity	1.38807279858296	bayes_pls_golite062009
ATPase activity, coupled	1.30978934925464	bayes_pls_golite062009
binding	1.29379382725969	bayes_pls_golite062009
amine transmembrane transporter activity	1.17315498514759	bayes_pls_golite062009
active transmembrane transporter activity	1.03879628103677	bayes_pls_golite062009
hydrolase activity	1.03530755572346	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	0.950885142938701	bayes_pls_golite062009
primary active transmembrane transporter activity	0.949033593388493	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	0.918484127528225	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	0.917033090233205	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	0.915324862636953	bayes_pls_golite062009
purine nucleotide binding	0.836987306348926	bayes_pls_golite062009
purine ribonucleotide binding	0.833439952483443	bayes_pls_golite062009
ribonucleotide binding	0.833225286154786	bayes_pls_golite062009
nucleotide binding	0.826434767038468	bayes_pls_golite062009
branched-chain aliphatic amino acid transmembrane transporter activity	0.442220326523999	bayes_pls_golite062009
ATP binding	0.304960869395329	bayes_pls_golite062009
adenyl ribonucleotide binding	0.276351989242018	bayes_pls_golite062009
adenyl nucleotide binding	0.265030176892253	bayes_pls_golite062009
catalytic activity	0.234613562021476	bayes_pls_golite062009
substrate-specific transporter activity	0.203102676509268	bayes_pls_golite062009
amino acid-transporting ATPase activity	0.147644650870465	bayes_pls_golite062009
amine-transporting ATPase activity	0.135455889967401	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: