YRC Public Data Repository - Protein Structure Prediction

Protein:	SRGAP3
Organism:	Homo sapiens
Length:	1099 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SRGAP3.

Description	E-value	Query Range	Subject Range
gi\|73985028 - gi\|73985028\|ref\|XP_852764.1\| PREDICTED: similar to SLIT-ROBO Rho GTPase activating protein 3 [Canis ...	0.0	[1..1099]	[1..1099]
gi\|76665098 - gi\|76665098\|ref\|XP_869609.1\| PREDICTED: similar to SLIT-ROBO Rho GTPase activating protein 3 isoform...	0.0	[1..1099]	[1..1099]
gi\|109473966, gi... - gi\|62648014\|ref\|XP_575637.1\| PREDICTED: similar to SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3...	0.0	[1..1099]	[1..1099]
SRGP3_MOUSE - SLIT-ROBO Rho GTPase-activating protein 3 OS=Mus musculus GN=Srgap3 PE=1 SV=1	0.0	[1..1099]	[1..1099]
gi\|109035846 - gi\|109035846\|ref\|XP_001097218.1\| PREDICTED: similar to SLIT-ROBO Rho GTPase activating protein 3 iso...	0.0	[1..1099]	[1..1099]
gi\|25535933 - gi\|25535933\|pir\|\|G59434 KIAA0411 protein [imported] - human	0.0	[1..1099]	[1..1075]

Back

Predicted Domain #1

Region A:
Residues: [1-324]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSQTKFKKD KEIIAEYEAQ IKEIRTQLVE QFKCLEQQSE SRLQLLQDLQ EFFRRKAEIE  60
   61 LEYSRSLEKL AERFSSKIRS SREHQFKKDQ YLLSPVNCWY LVLHQTRRES RDHATLNDIF 120
  121 MNNVIVRLSQ ISEDVIRLFK KSKEIGLQMH EELLKVTNEL YTVMKTYHMY HAESISAESK 180
  181 LKEAEKQEEK QFNKSGDLSM NLLRHEDRPQ RRSSVKKIEK MKEKRQAKYS ENKLKCTKAR 240
  241 NDYLLNLAAT NAAISKYYIH DVSDLIDCCD LGFHASLART FRTYLSAEYN LETSRHEGLD 300
  301 VIENAVDNLD SRSDKHTVMD MCNQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	23.0
Match:	1i84S
Description:	Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [325-698]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VFCPPLKFEF QPHMGDEVCQ VSAQQPVQTE LLMRYHQLQS RLATLKIENE EVRKTLDATM  60
   61 QTLQDMLTVE DFDVSDAFQH SRSTESVKSA ASETYMSKIN IAKRRANQQE TEMFYFTKFK 120
  121 EYVNGSNLIT KLQAKHDLLK QTLGEGERAE CGTTRPPCLP PKPQKMRRPR PLSVYSHKLF 180
  181 NGSMEAFIKD SGQAIPLVVE SCIRYINLYG LQQQGIFRVP GSQVEVNDIK NSFERGEDPL 240
  241 VDDQNERDIN SVAGVLKLYF RGLENPLFPK ERFQDLISTI KLENPAERVH QIQQILVTLP 300
  301 RVVIVVMRYL FAFLNHLSQY SDENMMDPYN LAICFGPTLM HIPDGQDPVS CQAHINEVIK 360
  361 TIIIHHEAIF PSPR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	47.0
Match:	1xa6A
Description:	Crystal Structure of the Human Beta2-Chimaerin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
Rho GTPase activator activity	4.58620967349979	bayes_pls_golite062009
Rac GTPase activator activity	4.48279904625182	bayes_pls_golite062009
cytoskeletal protein binding	3.42802398019084	bayes_pls_golite062009
binding	2.79128751898373	bayes_pls_golite062009
GTPase regulator activity	2.70614727793157	bayes_pls_golite062009
nucleoside-triphosphatase regulator activity	2.68579854252375	bayes_pls_golite062009
actin binding	2.59114492135519	bayes_pls_golite062009
tubulin binding	2.31518443151057	bayes_pls_golite062009
guanyl-nucleotide exchange factor activity	2.06038764955701	bayes_pls_golite062009
enzyme regulator activity	1.9750017471254	bayes_pls_golite062009
small GTPase regulator activity	1.95738547986197	bayes_pls_golite062009
motor activity	1.59872328451279	bayes_pls_golite062009
microtubule binding	1.39416664093439	bayes_pls_golite062009
Rho GTPase binding	1.34980300847466	bayes_pls_golite062009
protein binding	1.29100556128076	bayes_pls_golite062009
molecular transducer activity	1.25507073225414	bayes_pls_golite062009
signal transducer activity	1.25507073225414	bayes_pls_golite062009
Ras GTPase activator activity	1.09070479183477	bayes_pls_golite062009
transcription regulator activity	1.08577758274384	bayes_pls_golite062009
Rho guanyl-nucleotide exchange factor activity	0.967362611034944	bayes_pls_golite062009
Ras guanyl-nucleotide exchange factor activity	0.958295643211986	bayes_pls_golite062009
actin filament binding	0.937704425867942	bayes_pls_golite062009
GTPase activator activity	0.717730683557543	bayes_pls_golite062009
nucleic acid binding	0.480348726111787	bayes_pls_golite062009
receptor activity	0.434186339265983	bayes_pls_golite062009
DNA binding	0.418154636457321	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	0.38335246506929	bayes_pls_golite062009
enzyme activator activity	0.298334474872045	bayes_pls_golite062009
microfilament motor activity	0.0746966011130201	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [699-876]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ELEGPVYEKC MAGGEEYCDS PHSEPGAIDE VDHDNGTEPH TSDEEVEQIE AIAKFDYMGR  60
   61 SPRELSFKKG ASLLLYHRAS EDWWEGRHNG VDGLIPHQYI VVQDMDDAFS DSLSQKADSE 120
  121 ASSGPLLDDK ASSKNDLQSP TEHISDYGFG GVMGRVRLRS DGAAIPRRRS GGDTHSPP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	7.045757
Match:	2dl8A
Description:	No description for 2dl8A was found.

Predicted Domain #4

Region A:
Residues: [877-928]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RGLGPSIDTP PRAAACPSSP HKIPLTRGRI ESPEKRRMAT FGSAGSINYP DK

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5

Region A:
Residues: [929-1099]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KALSEGHSMR STCGSTRHSS LGDHKSLEAE ALAEDIEKTM STALHELREL ERQNTVKQAP  60
   61 DVVLDTLEPL KNPPGPVSSE PASPLHTIVI RDPDAAMRRS SSSSTEMMTT FKPALSARLA 120
  121 GAQLRPPPMR PVRPVVQHRS SSSSSSGVGS PAVTPTEKMF PNSSADKSGT M

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: