YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|3426027, gi\|7...
Organism:	Homo sapiens
Length:	671 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|3426027, gi|7....

Description	E-value	Query Range	Subject Range
RIPK1 - receptor (TNFRSF)-interacting serine-threonine kinase 1	475.0	[0..1]	[671..1]
gi\|114605229, gi... - gi\|114605231\|ref\|XP_001161146.1\| PREDICTED: receptor (TNFRSF)-interacting serine-threonine kinase 1 ...	474.0	[0..1]	[671..171]
gi\|109069441 - gi\|109069441\|ref\|XP_001091986.1\| PREDICTED: similar to receptor (TNFRSF)-interacting serine-threonin...	468.0	[0..1]	[671..1]
gi\|78042490, gi\|... - gi\|78042490\|ref\|NP_001030184.1\| receptor (TNFRSF)-interacting serine-threonine kinase 1 [Bos taurus]...	422.0	[0..5]	[671..1]
gi\|67970349 - gi\|67970349\|dbj\|BAE01517.1\| unnamed protein product [Macaca fascicularis]	421.0	[0..66]	[671..1]
gi\|149045237, gi... - gi\|157824041\|ref\|NP_001100820.1\| receptor (TNFRSF)-interacting serine-threonine kinase 1 [Rattus nor...	414.0	[0..1]	[671..1]
gi\|74003988 - gi\|74003988\|ref\|XP_545317.2\| PREDICTED: similar to receptor (TNFRSF)-interacting serine-threonine ki...	412.0	[0..2]	[671..161]
RIPK1_MOUSE - Receptor-interacting serine/threonine-protein kinase 1 OS=Mus musculus GN=Ripk1 PE=1 SV=1	406.0	[0..1]	[671..1]

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Predicted Domain #1

Region A:
Residues: [1-382]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQPDMSLNVI KMKSSDFLES AELDSGGFGK VSLCFHRTQG LMIMKTVYKG PNCIEHNEAL  60
   61 LEEAKMMNRL RHSRVVKLLG VIIEEGKYSL VMEYMEKGNL MHVLKAEMST PLSVKGRIIL 120
  121 EIIEGMCYLH GKGVIHKDLK PENILVDNDF HIKIADLGLA SFKMWSKLNN EEHNELREVD 180
  181 GTAKKNGGTL YYMAPEHLND VNAKPTEKSD VYSFAVVLWA IFANKEPYEN AICEQQLIMC 240
  241 IKSGNRPDVD DITEYCPREI ISLMKLCWEA NPEARPTFPG IEEKFRPFYL SQLEESVEED 300
  301 VKSLKKEYSN ENAVVKRMQS LQLDCVAVPS SRSNSATEQP GSLHSSQGLG MGPVEESWFA 360
  361 PSLEHPQEEN EPSLQSKLQD EA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	70.522879
Match:	2qnjA
Description:	No description for 2qnjA was found.

Predicted Domain #2

Region A:
Residues: [383-576]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NYHLYGSRMD RQTKQQPRQN VAYNREEERR RRVSHDPFAQ QRPYENFQNT EGKGTVYSSA  60
   61 ASHGNAVHQP SGLTSQPQVL YQNNGLYSSH GFGTRPLDPG TAGPRVWYRP IPSHMPSLHN 120
  121 IPVPETNYLG NTPTMPFSSL PPTDESIKYT IYNSTGIQIG AYNYMEIGGT SSSLLDSTNT 180
  181 NFKEEPAAKY QAIF

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [577-671]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DNTTSLTDKH LDPIRENLGK HWKNCARKLG FTQSQIDEID HDYERDGLKE KVYQMLQKWV  60
   61 MREGIKGATV GKLAQALHQC SRIDLLSSLI YVSQN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	10.221849
Match:	1fadA
Description:	FADD (Mort1)
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits