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View Structure Prediction Details

Protein: CD3D
Organism: Homo sapiens
Length: 171 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CD3D.

Description E-value Query
Range		 Subject
Range
gi|74150307 - gi|74150307|dbj|BAE32208.1| unnamed protein product [Mus musculus]
 2.0E-45 [1..171] [1..171]
gi|109108856 - gi|109108856|ref|XP_001097302.1| PREDICTED: CD3d molecule, delta (CD3-TCR complex) [Macaca mulatta]
 1.0E-44 [1..171] [1..171]
CD3D_MACFA - T-cell surface glycoprotein CD3 delta chain OS=Macaca fascicularis GN=CD3D PE=2 SV=1
 1.0E-44 [1..171] [1..171]
CD3D_RAT - T-cell surface glycoprotein CD3 delta chain OS=Rattus norvegicus GN=Cd3d PE=2 SV=1
 7.0E-44 [1..171] [1..171]
gi|224309 - gi|224309|prf||1101394A protein delta T3,glyco
 2.0E-43 [1..171] [1..171]
gi|114640611 - gi|114640611|ref|XP_508789.2| PREDICTED: hypothetical protein [Pan troglodytes]
 2.0E-43 [1..171] [1..171]
gi|57085933 - gi|57085933|ref|XP_536556.1| PREDICTED: similar to T-cell surface glycoprotein CD3 delta chain precu...
 1.0E-41 [1..171] [1..171]

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Predicted Domain #1
Region A:
Residues: [1-99] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEHSTFLSGL VLATLLSQVS PFKIPIEELE DRVFVNCNTS ITWVEGTVGT LLSDITRLDL  60
   61 GKRILDPRGI YRCNGTDIYK DKESTVQVHY RMCQSCVEL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.69897
Match: 1xiwB
Description: Crystal structure of human CD3-e/d dimer in complex with a UCHT1 single-chain antibody fragment
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
receptor activity 4.00123250685257 bayes_pls_golite062009
transmembrane receptor activity 3.81769911097805 bayes_pls_golite062009
antigen binding 3.16266926144655 bayes_pls_golite062009
molecular transducer activity 3.10913345555941 bayes_pls_golite062009
signal transducer activity 3.10913345555941 bayes_pls_golite062009
binding 2.53652619212064 bayes_pls_golite062009
T cell receptor binding 2.12089279430732 bayes_pls_golite062009
peptide antigen binding 1.66960790017756 bayes_pls_golite062009
protein binding 1.17809977833322 bayes_pls_golite062009
G-protein coupled receptor activity 1.02428106476324 bayes_pls_golite062009
receptor binding 0.909733688848793 bayes_pls_golite062009
immunoglobulin binding 0.84834833214265 bayes_pls_golite062009
protein complex binding 0.83543827718565 bayes_pls_golite062009
peptide binding 0.729048089532569 bayes_pls_golite062009
coreceptor activity 0.661209696849389 bayes_pls_golite062009
growth factor binding 0.53454839799174 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.447829399094714 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 0.28309679787333 bayes_pls_golite062009
olfactory receptor activity 0.20101044847022 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [100-171] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DPATVAGIIV TDVIATLLLA LGVFCFAGHE TGRLSGAADT QALLRNDQVY QPLRDRDDAQ  60
   61 YSHLGGNWAR NK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle