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View Structure Prediction Details

Protein: NSFL1C
Organism: Homo sapiens
Length: 370 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NSFL1C.

Description E-value Query
Range
Subject
Range
NSF1C_RAT - NSFL1 cofactor p47 OS=Rattus norvegicus GN=Nsfl1c PE=1 SV=1
0.0 [1..370] [1..370]
NSF1C_MOUSE - NSFL1 cofactor p47 OS=Mus musculus GN=Nsfl1c PE=1 SV=1
0.0 [1..370] [1..370]
NSF1C_BOVIN - NSFL1 cofactor p47 OS=Bos taurus GN=NSFL1C PE=2 SV=1
0.0 [1..370] [1..370]
gi|193787565, gi... - gi|62898243|dbj|BAD97061.1| p47 protein isoform a variant [Homo sapiens], gi|5531827|gb|AAD44488.1| ...
0.0 [1..370] [1..370]
gi|109092584 - gi|109092584|ref|XP_001113343.1| PREDICTED: similar to p47 protein isoform a isoform 8 [Macaca mulat...
0.0 [1..370] [1..370]
gi|114680493 - gi|114680493|ref|XP_001154020.1| PREDICTED: p47 protein isoform 5 [Pan troglodytes]
0.0 [1..370] [1..372]

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Predicted Domain #1
Region A:
Residues: [1-68]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAERQEALR EFVAVTGAEE DRARFFLESA GWDLQIALAS FYEDGGDEDI VTISQATPSS  60
   61 VSRGTAPS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [69-160]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DNRVTSFRDL IHDQDEDEEE EEGQRFYAGG SERSGQQIVG PPRKKSPNEL VDDLFKGAKE  60
   61 HGAVAVERVT KSPGETSKPR PFAGGGYRLG AA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [161-271]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PEEESAYVAG EKRQHSSQDV HVVLKLWKSG FSLDNGELRS YQDPSNAQFL ESIRRGEVPA  60
   61 ELRRLAHGGQ VNLDMEDHRD EDFVKPKGAF KAFTGEGQKL GSTAPQVLST S

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 20.69897
Match: 1ss6A
Description: Solution structure of SEP domain from human p47
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [272-370]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPAQQAENEA KASSSILIDE SEPTTNIQIR LADGGRLVQK FNHSHRISDI RLFIVDARPA  60
   61 MAATSFILMT TFPNKELADE SQTLKEANLL NAVIVQRLT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.69897
Match: 1s3sG
Description: Crystal structure of AAA ATPase p97/VCP ND1 in complex with p47 C
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.73741203922834 bayes_pls_golite062009
protein binding 1.6357717410164 bayes_pls_golite062009
small conjugating protein ligase activity 1.16524840930815 bayes_pls_golite062009
ubiquitin-protein ligase activity 0.544811416739 bayes_pls_golite062009
acid-amino acid ligase activity 0.288560953468985 bayes_pls_golite062009
hydrolase activity 0.0740461973842489 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle