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View Structure Prediction Details

Protein: TNFSF10
Organism: Homo sapiens
Length: 281 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TNFSF10.

Description E-value Query
Range
Subject
Range
gi|114590406, gi... - gi|55621492|ref|XP_516879.1| PREDICTED: tumor necrosis factor (ligand) superfamily, member 10 isofor...
4.0E-98 [1..281] [1..281]
gi|54695996, gi|... - gi|61368225|gb|AAX43133.1| tumor necrosis factor superfamily member 10 [synthetic construct], gi|546...
1.0E-97 [1..281] [1..281]
gi|109044265 - gi|109044265|ref|XP_001084768.1| PREDICTED: tumor necrosis factor (ligand) superfamily, member 10 [M...
gi|90083054 - gi|90083054|dbj|BAE90609.1| unnamed protein product [Macaca fascicularis]
1.0E-94 [1..281] [1..281]
gi|54311147 - gi|54311147|gb|AAH20220.1| TNFSF10 protein [Homo sapiens]
1.0E-94 [1..278] [1..279]
gi|67010017, gi|... - gi|67010017|ref|NP_001019867.1| tumor necrosis factor (ligand) superfamily, member 10 [Sus scrofa], ...
5.0E-86 [1..281] [1..289]
TNF10_MOUSE - Tumor necrosis factor ligand superfamily member 10 OS=Mus musculus GN=Tnfsf10 PE=2 SV=1
2.0E-83 [12..280] [16..290]
gi|45383402, gi|... - gi|45383402|ref|NP_989710.1| tumor necrosis factor (ligand) superfamily, member 10 [Gallus gallus], ...
3.0E-78 [6..280] [3..290]

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Predicted Domain #1
Region A:
Residues: [1-92]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAMMEVQGGP SLGQTCVLIV IFTVLLQSLC VAVTYVYFTN ELKQMQDKYS KSGIACFLKE  60
   61 DDSYWDPNDE ESMNSPCWQV KWQLRQLVRK MI

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [93-281]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LRTSEETIST VQEKQQNISP LVRERGPQRV AAHITGTRGR SNTLSSPNSK NEKALGRKIN  60
   61 SWESSRSGHS FLSNLHLRNG ELVIHEKGFY YIYSQTYFRF QEEIKENTKN DKQMVQYIYK 120
  121 YTSYPDPILL MKSARNSCWS KDAEYGLYSI YQGGIFELKE NDRIFVSVTN EHLIDMDHEA 180
  181 SFFGAFLVG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 60.69897
Match: 1dg6A
Description: Apoptosis-2 ligand, apo2l/TRAIL
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
CD40 receptor binding 3.4607762965927 bayes_pls_golite062009
receptor binding 3.37824597039547 bayes_pls_golite062009
tumor necrosis factor receptor superfamily binding 3.27382150819697 bayes_pls_golite062009
protein binding 2.25413201891408 bayes_pls_golite062009
binding 1.55055236820725 bayes_pls_golite062009
cytokine activity 1.44696622202601 bayes_pls_golite062009
cell surface binding 1.12145675554147 bayes_pls_golite062009
tumor necrosis factor receptor binding 0.83659914028185 bayes_pls_golite062009
eukaryotic cell surface binding 0.3981620493951 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle