YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: LGTN
Organism: Homo sapiens
Length: 584 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LGTN.

Description E-value Query
Range
Subject
Range
gi|114572164 - gi|114572164|ref|XP_514150.2| PREDICTED: ligatin [Pan troglodytes]
0.0 [1..584] [100..683]
EIF2D_PONAB - Eukaryotic translation initiation factor 2D OS=Pongo abelii GN=EIF2D PE=2 SV=1
LIGA_PONPY - Ligatin - Pongo pygmaeus (Orangutan)
0.0 [1..584] [1..584]
LGTN - ligatin
0.0 [1..584] [1..584]
gi|109018597 - gi|109018597|ref|XP_001086830.1| PREDICTED: similar to ligatin isoform 4 [Macaca mulatta]
0.0 [1..584] [1..584]
EIF2D_MOUSE - Eukaryotic translation initiation factor 2D OS=Mus musculus GN=Eif2d PE=1 SV=3
0.0 [1..583] [1..570]

Back

Predicted Domain #1
Region A:
Residues: [1-180]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFAKAFRVKS NTAIKGSDRR KLRADVTTAF PTLGTDQVSE LVPGKEELNI VKLYAHKGDA  60
   61 VTVYVSGGNP ILFELEKNLY PTVYTLWSYP DLLPTFTTWP LVLEKLVGGA DLMLPGLVMP 120
  121 PAGLPQVQKG DLCAISLVGN RAPVAIGVAA MSTAEMLTSG LKGRGFSVLH TYQDHLWRSG 180
  181 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 40.39794
Match: 2ausC
Description: No description for 2ausC was found.

Predicted Domain #2
Region A:
Residues: [181-248]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKSSPPSIAP LALDSADLSE EKGSVQMDST LQGDMRHMTL EGEEENGEVH QAREDKSLSE  60
   61 APEDTSTR

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [249-358]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GLNQDSTDSK TLQEQMDELL QQCFLHALKC RVKKADLPLL TSTFLGSHMF SCCPEGRQLD  60
   61 IKKSSYKKLS KFLQQMQQEQ IIQVKELSKG VESIVAVDWK HPRITSFVIP 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [359-468]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EPSPTSQTIQ EGSREQPYHP PDIKPLYCVP ASMTLLFQES GHKKGSFLEG SEVRTIVINY  60
   61 AKKNDLVDAD NKNLVRLDPI LCDCILEKNE QHTVMKLPWD SLLTRCLEKL 

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.32
Match: 1v32A
Description: Solution structure of the SWIB/MDM2 domain of the hypothetical protein At5g08430 from Arabidopsis thaliana
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
structural molecule activity 4.72233209840291 bayes_pls_golite062009
protein binding 2.52181725362933 bayes_pls_golite062009
binding 2.18328191469694 bayes_pls_golite062009
transcription regulator activity 1.77240364924631 bayes_pls_golite062009
transcription activator activity 0.995535823852062 bayes_pls_golite062009
transcription repressor activity 0.464336112087611 bayes_pls_golite062009
basal transcription repressor activity 0.307849920263354 bayes_pls_golite062009
transcription factor binding 0.203735997461782 bayes_pls_golite062009
catalytic activity 0.151165614150825 bayes_pls_golite062009
transcription cofactor activity 0.125030292437611 bayes_pls_golite062009
transcription coactivator activity 0.012901717642134 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [469-584]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QPAYQVTLPG QEPIVKKGRI CPIDITLAQR ASNKKVTVVR NLEAYGLDPY SVAAILQQRC  60
   61 QASTTVNPAP GAKDSLQVQI QGNQVHHLGW LLLEEYQLPR KHIQGLEKAL KPGKKK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 30.39794
Match: 2if1A
Description: HUMAN TRANSLATION INITIATION FACTOR EIF1, NMR, 29 STRUCTURES
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
translation initiation factor activity 6.56930940751046 bayes_pls_golite062009
translation regulator activity 2.27579767245564 bayes_pls_golite062009
translation factor activity, nucleic acid binding 2.25914933413253 bayes_pls_golite062009
binding 1.99916637558859 bayes_pls_golite062009
nucleic acid binding 1.69119554284364 bayes_pls_golite062009
protein binding 1.47118967208188 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle