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View Structure Prediction Details

Protein: TNF10_MOUSE
Organism: Mus musculus
Length: 291 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TNF10_MOUSE.

Description E-value Query
Range
Subject
Range
gi|74185998 - gi|74185998|dbj|BAE34141.1| unnamed protein product [Mus musculus]
340.0 [0..1] [291..1]
gi|21429683, gi|... - gi|21728412|ref|NP_663714.1| tumor necrosis factor (ligand) superfamily, member 10 [Rattus norvegicu...
307.0 [0..1] [287..1]
TNFSF10 - tumor necrosis factor (ligand) superfamily, member 10
gi|123979940, gi... - gi|123994707|gb|ABM84955.1| tumor necrosis factor (ligand) superfamily, member 10 [synthetic constru...
299.0 [0..9] [290..9]
gi|54695996, gi|... - gi|61368225|gb|AAX43133.1| tumor necrosis factor superfamily member 10 [synthetic construct], gi|546...
299.0 [0..9] [290..9]
gi|114590406, gi... - gi|55621492|ref|XP_516879.1| PREDICTED: tumor necrosis factor (ligand) superfamily, member 10 isofor...
297.0 [0..9] [290..9]
gi|109044265 - gi|109044265|ref|XP_001084768.1| PREDICTED: tumor necrosis factor (ligand) superfamily, member 10 [M...
gi|90083054 - gi|90083054|dbj|BAE90609.1| unnamed protein product [Macaca fascicularis]
295.0 [0..12] [290..8]

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Predicted Domain #1
Region A:
Residues: [1-103]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPSSGALKDL SFSQHFRMMV ICIVLLQVLL QAVSVAVTYM YFTNEMKQLQ DNYSKIGLAC  60
   61 FSKTDEDFWD STDGEILNRP CLQVKRQLYQ LIEEVTLRTF QDT

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [104-291]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ISTVPEKQLS TPPLPRGGRP QKVAAHITGI TRRSNSALIP ISKDGKTLGQ KIESWESSRK  60
   61 GHSFLNHVLF RNGELVIEQE GLYYIYSQTY FRFQEAEDAS KMVSKDKVRT KQLVQYIYKY 120
  121 TSYPDPIVLM KSARNSCWSR DAEYGLYSIY QGGLFELKKN DRIFVSVTNE HLMDLDQEAS 180
  181 FFGAFLIN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 52.522879
Match: 1dg6A
Description: Apoptosis-2 ligand, apo2l/TRAIL
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
receptor binding 3.37824597039547 bayes_pls_golite062009
tumor necrosis factor receptor superfamily binding 2.2657673851253 bayes_pls_golite062009
protein binding 2.25413201891408 bayes_pls_golite062009
binding 1.55055236820725 bayes_pls_golite062009
tumor necrosis factor receptor binding 1.07319043778379 bayes_pls_golite062009
cytokine activity 0.82341093302063 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle