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View Structure Prediction Details

Protein: U119A_MOUSE
Organism: Mus musculus
Length: 240 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for U119A_MOUSE.

Description E-value Query
Range
Subject
Range
U119A_RAT - Protein unc-119 homolog A OS=Rattus norvegicus GN=Unc119 PE=1 SV=1
393.0 [0..1] [240..1]
gi|56206000 - gi|56206000|emb|CAI24316.1| unc-119 homolog (C. elegans) [Mus musculus]
385.0 [0..1] [240..1]
gi|114668508 - gi|114668508|ref|XP_001145903.1| PREDICTED: similar to retinal protein isoform 2 [Pan troglodytes]
373.0 [0..1] [240..1]
UNC119 - unc-119 homolog (C. elegans)
371.0 [0..1] [240..1]
U119A_BOVIN - Protein unc-119 homolog A OS=Bos taurus GN=UNC119 PE=2 SV=1
360.0 [0..1] [240..1]
gi|47086467, gi|... - gi|47086467|ref|NP_997952.1| unc-119 homolog 1 [Danio rerio], gi|190339388|gb|AAI62287.1| Unc-119 ho...
356.0 [0..12] [239..10]
gi|57091859 - gi|57091859|ref|XP_548289.1| PREDICTED: similar to Unc-119 protein homolog (Retinal protein 4) (HRG4...
355.0 [0..1] [240..1]

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Predicted Domain #1
Region A:
Residues: [1-107]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKVKKGGGGT GSGAEPVPGA SNRSAEPTRE PGAEAESGSE SEPEPGPGPR LGPLQGKQPI  60
   61 GPEDVLGLQR ITGDYLCSPE ENIYKIDFVR FKIRDMDSGT VLFEIKK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.297 d.137.1 Monooxygenase (hydroxylase) regulatory protein

Predicted Domain #2
Region A:
Residues: [108-240]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPVSERLPIN RRDLDPNAGR FVRYQFTPAF LRLRQVGATV EFTVGDKPVN NFRMIERHYF  60
   61 RNQLLKSFDF HFGFCIPSSK NTCEHIYDFP PLSEELISEM IRHPYETQSD SFYFVDDRLV 120
  121 MHNKADYSYS GTP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 46.522879
Match: 1ksgB
Description: GMP-PDE delta
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.79148906288627 bayes_pls_golite062009
ligand-gated channel activity 1.5302582659987 bayes_pls_golite062009
ligand-gated ion channel activity 1.5302582659987 bayes_pls_golite062009
protein binding 1.48353517714382 bayes_pls_golite062009
gated channel activity 1.42896395862304 bayes_pls_golite062009
cation channel activity 1.4256218398774 bayes_pls_golite062009
ion channel activity 1.40005559320777 bayes_pls_golite062009
substrate-specific channel activity 1.36653752383074 bayes_pls_golite062009
channel activity 1.35767020846709 bayes_pls_golite062009
passive transmembrane transporter activity 1.35767020846709 bayes_pls_golite062009
metarhodopsin binding 0.869827712400021 bayes_pls_golite062009
voltage-gated cation channel activity 0.855931938850398 bayes_pls_golite062009
opsin binding 0.839214663991459 bayes_pls_golite062009
voltage-gated ion channel activity 0.789955030733139 bayes_pls_golite062009
voltage-gated channel activity 0.780717736949525 bayes_pls_golite062009
potassium channel activity 0.559325988586613 bayes_pls_golite062009
metal ion transmembrane transporter activity 0.521778252711535 bayes_pls_golite062009
voltage-gated potassium channel activity 0.512152861387956 bayes_pls_golite062009
inward rectifier potassium channel activity 0.0912506266585198 bayes_pls_golite062009

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