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View Structure Prediction Details

Protein: CSN4-PB, CSN4-PA
Organism: Drosophila melanogaster
Length: 407 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CSN4-PB, CSN4-PA.

Description E-value Query
Range
Subject
Range
CSN4_DANRE - COP9 signalosome complex subunit 4 OS=Danio rerio GN=cops4 PE=2 SV=1
260.0 [0..9] [406..2]

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Predicted Domain #1
Region A:
Residues: [1-137]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAANYGISTA ALRSQLMGLI NFTGTHKDQA DKYRQLLKTV LTNTGQELID GLRLFVEAIV  60
   61 NEHVSLVISR QILNDVGSEL SKLPDDLSKM LSHFTLEKVN PRVISFEEQV AGIRFHLANI 120
  121 YERNQQWRDA ATVLVGI

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [138-279]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLETGQKQYS VECKLGTYLK IARLYLEDND SVQAELFINR ASLLQAETNS EELQVLYKVC  60
   61 YARVLDYRRK FIEAAQRYNE LSYRKIVDQG ERMTALKKAL ICTVLASAGQ QRSRMLATLF 120
  121 KDERCQHLPA YGILEKMYLE RI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [280-407]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IRRSELQEFE ALLQDHQKAA TSDGSSILDR AVFEHNLLSA SKLYNNITFE ELGALLDIPA  60
   61 VKAEKIASQM ITEGRMNGHI DQISAIVHFE NRELLPQWDR QIQSLCYQVN SIIEKISVAE 120
  121 PDWMDNLN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.0
Match: 1ufmA
Description: Solution structure of the PCI domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.09178084244715 bayes_pls_golite062009
DNA binding 4.69269372393889 bayes_pls_golite062009
nucleic acid binding 4.59221092058767 bayes_pls_golite062009
transcription factor activity 4.01234546864709 bayes_pls_golite062009
binding 3.52874320222492 bayes_pls_golite062009
transcription repressor activity 3.28015281691988 bayes_pls_golite062009
sequence-specific DNA binding 2.23304004014963 bayes_pls_golite062009
transcription activator activity 2.21230033124772 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.40206639526766 bayes_pls_golite062009
small conjugating protein ligase activity 1.27763700765562 bayes_pls_golite062009
ubiquitin-protein ligase activity 1.12147035668008 bayes_pls_golite062009
transcription factor binding 0.78051974537344 bayes_pls_golite062009
acid-amino acid ligase activity 0.754042916649094 bayes_pls_golite062009
protein binding 0.753698599635855 bayes_pls_golite062009
specific transcriptional repressor activity 0.59003343009795 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 0.486434906547244 bayes_pls_golite062009
hydrolase activity 0.140191206949582 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle