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View Structure Prediction Details

Protein: CSN4-PB, CSN4-PA
Organism: Drosophila melanogaster
Length: 407 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CSN4-PB, CSN4-PA.

Description E-value Query
Range
Subject
Range
CSN4_DANRE - COP9 signalosome complex subunit 4 OS=Danio rerio GN=cops4 PE=2 SV=1
260.0 [0..9] [406..2]

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Predicted Domain #1
Region A:
Residues: [1-137]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAANYGISTA ALRSQLMGLI NFTGTHKDQA DKYRQLLKTV LTNTGQELID GLRLFVEAIV  60
   61 NEHVSLVISR QILNDVGSEL SKLPDDLSKM LSHFTLEKVN PRVISFEEQV AGIRFHLANI 120
  121 YERNQQWRDA ATVLVGI

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [138-279]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLETGQKQYS VECKLGTYLK IARLYLEDND SVQAELFINR ASLLQAETNS EELQVLYKVC  60
   61 YARVLDYRRK FIEAAQRYNE LSYRKIVDQG ERMTALKKAL ICTVLASAGQ QRSRMLATLF 120
  121 KDERCQHLPA YGILEKMYLE RI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [280-407]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IRRSELQEFE ALLQDHQKAA TSDGSSILDR AVFEHNLLSA SKLYNNITFE ELGALLDIPA  60
   61 VKAEKIASQM ITEGRMNGHI DQISAIVHFE NRELLPQWDR QIQSLCYQVN SIIEKISVAE 120
  121 PDWMDNLN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.0
Match: 1ufmA
Description: Solution structure of the PCI domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.09178084244715 bayes_pls_golite062009
DNA binding 4.69269372393889 bayes_pls_golite062009
nucleic acid binding 4.59221092058767 bayes_pls_golite062009
transcription factor activity 4.01234546864709 bayes_pls_golite062009
binding 3.52874320222492 bayes_pls_golite062009
transcription repressor activity 3.28015281691988 bayes_pls_golite062009
sequence-specific DNA binding 2.23304004014963 bayes_pls_golite062009
transcription activator activity 2.21230033124772 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.40206639526766 bayes_pls_golite062009
small conjugating protein ligase activity 1.27763700765562 bayes_pls_golite062009
ubiquitin-protein ligase activity 1.12147035668008 bayes_pls_golite062009
transcription factor binding 0.78051974537344 bayes_pls_golite062009
acid-amino acid ligase activity 0.754042916649094 bayes_pls_golite062009
protein binding 0.753698599635855 bayes_pls_golite062009
specific transcriptional repressor activity 0.59003343009795 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 0.486434906547244 bayes_pls_golite062009
hydrolase activity 0.140191206949582 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle