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View Structure Prediction Details

Protein: loco-PB
Organism: Drosophila melanogaster
Length: 1175 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for loco-PB.

Description E-value Query
Range
Subject
Range
gi|4581016 - gi|4581016|gb|AAD24580.1|AF130744_1 regulator of G-protein signalling LOCO C2 [Drosophila melanogast...
1080.0 [0..1] [1175..1]

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Predicted Domain #1
Region A:
Residues: [1-190]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNNTNTTRGT CSRIPIASKQ EPTIASMVER FVQSLSQLND SGTFDSSFEI KRIHPGSSAG  60
   61 STPKHVRHRC LTELDREQLT RFVQDFEERQ ASTPKVKSKI SSPYICRKAK EFYQSASGRR 120
  121 SASPQITIAP ETVQEEKVLV NPLPRKCAEA EDLMPPPMAM ARVQAERRSC RSASRVLQFF 180
  181 SSATKRRSGN 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [191-396]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RKLSEPEMED NRADSPVLIR VTRDRVEEQL GCSPLAASGG EVPTSSEDEE EHDDGISSAS  60
   61 SNLTSQSGSS NSRNLSPDSS FEMHAPLLPS FKVTPPRAVC RVGKNAACEF ARFLRGSFHS 120
  121 KRASVTTLRR SLSDPDAVQQ MDFSKPPPLR DTTNVMRNRA LPANASPFRR AWGQSSFRTP 180
  181 RSDKVAKEQQ QLGQSSPVRR TASMNA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [397-600]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SDNDMYIKTL MLDSDLKSSR SQHQLSLLQV PKVLTTPAPP SAITASVAAE GAAQDHGCPS  60
   61 SWAGSFERML QDAAGMQTFS EFLKKEFSAE NIYFWTACER YRLLESEADR VAQAREIFAK 120
  121 HLANNSSDPV NVDSQARSLT EEKLADAAPD IFAPAQKQIF SLMKFDSYQR FIRSDLYKSC 180
  181 VEAEQKNQPL PYSGLDLDEL LKTN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 56.69897
Match: 1agrE
Description: Regulator of G-protein signalling 4, RGS4
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
GTPase regulator activity 1.92987277493861 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 1.90800479999702 bayes_pls_golite062009
GTPase activator activity 1.87534424848905 bayes_pls_golite062009
binding 1.71250041369331 bayes_pls_golite062009
enzyme activator activity 1.62073651679221 bayes_pls_golite062009
enzyme regulator activity 1.49796137854909 bayes_pls_golite062009
protein binding 1.34804002381061 bayes_pls_golite062009
signal transducer activity 1.14361809679544 bayes_pls_golite062009
molecular transducer activity 1.14361809679544 bayes_pls_golite062009
beta-catenin binding 0.59248827140739 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [601-690]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FHLGAFSKLK KSASNAEDRR RKSLLPWHRK TRSKSRDRTE IMADMQHALM PAPPVPQNAP  60
   61 LTSASLKLVC GQNSLSDLHS SRSSLSSFDA 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [691-779]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GTATGGQGAS TESVYSLCRV ILTDGATTIV QTRPGETVGE LVERLLEKRN LVYPYYDIVF  60
   61 QGSTKSIDVQ QPSQILAGKE VVIERRVAF

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.7
Match: 1rrbA
Description: THE RAS-BINDING DOMAIN OF RAF-1 FROM RAT, NMR, 1 STRUCTURE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cytoskeletal protein binding 3.28306198153429 bayes_pls_golite062009
binding 2.0688320293797 bayes_pls_golite062009
protein binding 1.72968950672856 bayes_pls_golite062009
signal transducer activity 1.07208466109379 bayes_pls_golite062009
molecular transducer activity 1.07208466109379 bayes_pls_golite062009
receptor binding 0.286966350616338 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [780-881]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KLDLPDPKVI SVKSKPKKQL HEVIRPILSK YNYKMEQVQV IMRDTQVPID LNQPVTMADG  60
   61 QRLRIVMVNS DFQVGGGSSM PPKQSKPMKP LPQGHLDELT NK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.69897
Match: 1wfyA
Description: Solution structure of the Ras-binding domain of mouse RGS14
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cytoskeletal protein binding 3.3713276381973 bayes_pls_golite062009
binding 2.14676646738549 bayes_pls_golite062009
protein binding 1.86841453215444 bayes_pls_golite062009
signal transducer activity 1.05682194741929 bayes_pls_golite062009
molecular transducer activity 1.05682194741929 bayes_pls_golite062009
receptor binding 0.298046142314417 bayes_pls_golite062009

Predicted Domain #7
Region A:
Residues: [882-1082]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VFNELLASKA DAAASEKSRP VDLCSMKSNE APSETSSLFE RMRRQQRDGG NIPASKLPKL  60
   61 KKKSTSSSQQ SEEAATTQAV ADPKKPIIAK LKAGVKLQVT ERVAEHQDEL LEGLKRAQLA 120
  121 RLEDQRGTEI NFDLPDFLKN KENLSAAVSK LRKVRASLSP VSKVPATPTE IPQPAPRLSI 180
  181 TRSQQPVSPM KVDQEPETDL P

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.522879
Match: 1i3qA
Description: RBP1
Matching Structure (courtesy of the PDB):

Predicted Domain #8
Region A:
Residues: [1083-1175]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AATQDQTEFA KAPPPLPPKP KVLPIKPSNW GVAQPTGNYC NKYSPSKQVP TSPKEASKPG  60
   61 TFASKIPLDL GRKSLEEAGS RCAYLDEPSS SFV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.09691
Match: 1deqA
Description: Fibrinogen
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
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