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View Structure Prediction Details

Protein: plexA-PA
Organism: Drosophila melanogaster
Length: 1945 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for plexA-PA.

Description E-value Query
Range
Subject
Range
gi|7511988, gi|4... - pir||T13937 plexin A - fruit fly (Drosophila melanogaster), gi|4056674|gb|AAD09425.1| plexin A [Dros...
1869.0 [0..1] [1945..1]

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Predicted Domain #1
Region A:
Residues: [1-759]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNFVLSVLLI AILKDKYDYW LPSRTGCQTL AANIWSDKTT AQNEPINLTN ANAPIKNAKN  60
   61 LNSTITNVAA FDTKLNHLLV DTITGRVFVG GVNRLYQLSP DLELSETVKT GPQNDSVECS 120
  121 ILDCPLNAVR SPTDNYNKVL LIDRATSRLI ACGSLFQGTC TVRNLQNVSI IEHEVPDAVV 180
  181 ANDANSSTVA FIAPGPPQHP VTNVMYVGVT YTNNSPYRSE IPAVASRSLE KTKMFQIASS 240
  241 AVTTGTRTFI NSYARETYFV NYVYGFSSER FSYFLTTQLK HSHHSSPKEY ITKLVRICQE 300
  301 DSNYYSYTEI PVECISDAQG GTKFNLVQAG FLGKPSSDLA QSLGISIQDD VLFAVFSKGE 360
  361 GNTPTNNSAL CIYSLKSIRR KFMQNIKSCF NGSGMRGLDF ISPSMPCVLT KLQTIGEDFC 420
  421 GLDVNSPLGG ETPITSVPVA MFNTKLTSVA ATSTSGYTVV FVGTSDGFLK KVVIESSSIA 480
  481 NEYASFAVDL GSEINRDMQF DNQNLYIYVM SKTKVSKVKV FDCSDYKTCG DCLGARDPYC 540
  541 GWCSLENKCS PRSNCQDDAN DPLYWVSYKT GKCTTITSVV PHQLQRTTAR TLELIIDHLP 600
  601 QLKENLICAF TTEDKALFTN ATKKRNGVNC TTPRTDMLPQ IEQGKHHFTA KLSVRTRNGP 660
  661 DLVSTDFTFF DCSTHSSCTR CVSSEFPCDW CVEAHRCTHD TAENCRNDIL VTGVSRIGPS 720
  721 YRSGPGFCPT INATGDGSEV LVAGGTSKSI KVKVHIIGQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 79.045757
Match: 2uzxB
Description: No description for 2uzxB was found.

Predicted Domain #2
Region A:
Residues: [760-1014]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FIVQTRFVCQ FNIEGRVTSL NAQLLGDTIY CDSMEFQYTS RSPNLTATFA VIWGGSKPLD  60
   61 NPHNIHVVIY RCREMADSCG ICLALSEKYN CGWCSSTNTC EVEEQCNKNK EGKTDWLNRS 120
  121 EICPNPEIHT FQPKTGPWEG GTNITIRGIN LGKNYNDIYS GVRIAGINCM PFPQFYIDTK 180
  181 QIVCTVDSPG EQMYRNGKIV VQIGDYRGES KEDYEFVDPK ILDFNPKFGP TSGGTEIHIT 240
  241 GKHLNAGSRI QASIN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.221849
Match: 1yo8A
Description: Strucuture of the C-terminal domain of human thrombospondin-2
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [1015-1189]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DHLPCKILST DSSQAICRTS ASPGIIEGRL KMSFDNGPRE FNDYNFKYVL DPTVEHVSSG  60
   61 PSGQIKVPKG IPAGGIRISV TGTQFTSIQN PNIYVVYNGE MYASPCRVQS DTEMECASPV 120
  121 VDVDSHVIEA ERPILLEYGF LMDNVLRVQN LSKVHNNHFE LYPNPEYFIF EERVK

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 5.031517
Match: PF01833.15
Description: No description for PF01833.15 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [1190-1273]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YFKSEYLTIN GRNLDRACKE SDVEVKIGNG FCNITSLSRQ QLTCRPPSEA TATKSMNGPE  60
   61 VIVRIGTSLE YRIGILSYES SNII

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 0.987
Match: 2cxkA
Description: Crystal structure of the TIG domain of human calmodulin-binding transcription activator 1 (CAMTA1)
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [1274-1547]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LDWGENVIFA VIATIVILLL IFVALLVAYK KKSSESSRVL RNMQEQMDIL ELRVAAECKE  60
   61 AFAELQTEMT DLTGDLTSGG IPFLDYRSYA MKILFPNHED HIVLQWERPE LLRKEKGLRI 120
  121 FGQLIMNKTF LLLFIRTLES NRYFSMRERV NVASLIMVTL QSKLEYCTDI LKTLLGDLIE 180
  181 KCIEGKSHPK LLLRRTESVA EKMLSAWFTF LLYKFLKECA GEPLYMLFRA VKGQVDKGPV 240
  241 DACTHEARYS LSEEKLIRQS IDFRPMNVYA SIIQ

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 16.568636
Match: PF08337.3
Description: No description for PF08337.3 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [1548-1687]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QPIFCNNLDM LPSHTENVSV KVLDCDTIGQ VKEKCLETIY RNIPSSQRPR KDDLDLEWRT  60
   61 GATGRVILYD EDVTSKTESE WKKLNTLQHY NVPDGAGLSL VPKQSSIYNF SILSDKNEKS 120
  121 HKYETLNISK YTSSSPTFSR 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 39.0
Match: 2r2oA
Description: No description for 2r2oA was found.

Predicted Domain #7
Region A:
Residues: [1688-1945]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AGSPLNNDMH ENGLRYWHLV KHHDSDMQKE GERVNKLVSE IYLTRLLATK GTLQKFVDDL  60
   61 FETIFSTAHR GSALPLAIKY MFDFLDDQAQ LHGITDPEVV HTWKSNSLPL RFWVNLIKNP 120
  121 NFVFDIHKSN IVDSCLSVVA QTFMDSCSTS DHRLGKDSPS SKLLYAKDIP EYRKWVDRYY 180
  181 RDIRDMSPIS DQDMNAMLAE ESRLHTTEFN TNCALHELYT YAVKYNEQLT VTLEEDEFSQ 240
  241 KQRLAFKLEQ VHNIMSSE

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.49
Match: 1nf1A
Description: GAP related domain of neurofibromin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
GTPase regulator activity 4.62613920988983 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 4.60285041042816 bayes_pls_golite062009
small GTPase regulator activity 4.29435235604933 bayes_pls_golite062009
GTPase activator activity 4.13669967154451 bayes_pls_golite062009
Ras GTPase activator activity 4.05218513298437 bayes_pls_golite062009
enzyme regulator activity 3.98479257898428 bayes_pls_golite062009
Rho GTPase activator activity 3.8483177561348 bayes_pls_golite062009
Rac GTPase activator activity 3.81745527802437 bayes_pls_golite062009
enzyme activator activity 3.68130398795056 bayes_pls_golite062009
ErbB-3 class receptor binding 2.28649100165615 bayes_pls_golite062009
protein binding 2.19203994051073 bayes_pls_golite062009
signal transducer activity 1.85770920700616 bayes_pls_golite062009
molecular transducer activity 1.85770920700616 bayes_pls_golite062009
receptor activity 1.82582454265265 bayes_pls_golite062009
binding 1.60176934286866 bayes_pls_golite062009
Rho guanyl-nucleotide exchange factor activity 0.764662318607061 bayes_pls_golite062009
receptor binding 0.0304154938872172 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle