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Protein Overview: plexA-PA

General Information:
Name(s) found: plexA-PA / FBpp0088287 [FlyBase]
Description(s) found:
Found 29 descriptions.
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  • The gene plexin A is referred to in FlyBase by the symbol Dmel\plexA (CG11081, FBgn0025741). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 4:1034030..1047720. It has the cytological map location 102F5-102F6. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: axon guidance; axon midline choice point recognition. 10 alleles are reported. The phenotypes of these alleles are annotated with: ventral nerve cord; intersegmental nerve; longitudinal connective; embryonic central nervous system; abdominal segmental nerve; abdominal intersegmental nerve; transverse nerve. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1945 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEA]
    intracellular [IEA]
    Biological Process: motor axon guidance [NAS]
    signal transduction [IEA]
    axon guidance [IMP]
    axon midline choice point recognition [IMP]
    Molecular Function: protein binding [IPI]
    semaphorin receptor activity [ISS][TAS]
    axon guidance receptor activity [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNFVLSVLLI AILKDKYDYW LPSRTGCQTL AANIWSDKTT AQNEPINLTN ANAPIKNAKN  60
   61 LNSTITNVAA FDTKLNHLLV DTITGRVFVG GVNRLYQLSP DLELSETVKT GPQNDSVECS 120
  121 ILDCPLNAVR SPTDNYNKVL LIDRATSRLI ACGSLFQGTC TVRNLQNVSI IEHEVPDAVV 180
  181 ANDANSSTVA FIAPGPPQHP VTNVMYVGVT YTNNSPYRSE IPAVASRSLE KTKMFQIASS 240
  241 AVTTGTRTFI NSYARETYFV NYVYGFSSER FSYFLTTQLK HSHHSSPKEY ITKLVRICQE 300
  301 DSNYYSYTEI PVECISDAQG GTKFNLVQAG FLGKPSSDLA QSLGISIQDD VLFAVFSKGE 360
  361 GNTPTNNSAL CIYSLKSIRR KFMQNIKSCF NGSGMRGLDF ISPSMPCVLT KLQTIGEDFC 420
  421 GLDVNSPLGG ETPITSVPVA MFNTKLTSVA ATSTSGYTVV FVGTSDGFLK KVVIESSSIA 480
  481 NEYASFAVDL GSEINRDMQF DNQNLYIYVM SKTKVSKVKV FDCSDYKTCG DCLGARDPYC 540
  541 GWCSLENKCS PRSNCQDDAN DPLYWVSYKT GKCTTITSVV PHQLQRTTAR TLELIIDHLP 600
  601 QLKENLICAF TTEDKALFTN ATKKRNGVNC TTPRTDMLPQ IEQGKHHFTA KLSVRTRNGP 660
  661 DLVSTDFTFF DCSTHSSCTR CVSSEFPCDW CVEAHRCTHD TAENCRNDIL VTGVSRIGPS 720
  721 YRSGPGFCPT INATGDGSEV LVAGGTSKSI KVKVHIIGQF IVQTRFVCQF NIEGRVTSLN 780
  781 AQLLGDTIYC DSMEFQYTSR SPNLTATFAV IWGGSKPLDN PHNIHVVIYR CREMADSCGI 840
  841 CLALSEKYNC GWCSSTNTCE VEEQCNKNKE GKTDWLNRSE ICPNPEIHTF QPKTGPWEGG 900
  901 TNITIRGINL GKNYNDIYSG VRIAGINCMP FPQFYIDTKQ IVCTVDSPGE QMYRNGKIVV 960
  961 QIGDYRGESK EDYEFVDPKI LDFNPKFGPT SGGTEIHITG KHLNAGSRIQ ASINDHLPCK1020
 1021 ILSTDSSQAI CRTSASPGII EGRLKMSFDN GPREFNDYNF KYVLDPTVEH VSSGPSGQIK1080
 1081 VPKGIPAGGI RISVTGTQFT SIQNPNIYVV YNGEMYASPC RVQSDTEMEC ASPVVDVDSH1140
 1141 VIEAERPILL EYGFLMDNVL RVQNLSKVHN NHFELYPNPE YFIFEERVKY FKSEYLTING1200
 1201 RNLDRACKES DVEVKIGNGF CNITSLSRQQ LTCRPPSEAT ATKSMNGPEV IVRIGTSLEY1260
 1261 RIGILSYESS NIILDWGENV IFAVIATIVI LLLIFVALLV AYKKKSSESS RVLRNMQEQM1320
 1321 DILELRVAAE CKEAFAELQT EMTDLTGDLT SGGIPFLDYR SYAMKILFPN HEDHIVLQWE1380
 1381 RPELLRKEKG LRIFGQLIMN KTFLLLFIRT LESNRYFSMR ERVNVASLIM VTLQSKLEYC1440
 1441 TDILKTLLGD LIEKCIEGKS HPKLLLRRTE SVAEKMLSAW FTFLLYKFLK ECAGEPLYML1500
 1501 FRAVKGQVDK GPVDACTHEA RYSLSEEKLI RQSIDFRPMN VYASIIQQPI FCNNLDMLPS1560
 1561 HTENVSVKVL DCDTIGQVKE KCLETIYRNI PSSQRPRKDD LDLEWRTGAT GRVILYDEDV1620
 1621 TSKTESEWKK LNTLQHYNVP DGAGLSLVPK QSSIYNFSIL SDKNEKSHKY ETLNISKYTS1680
 1681 SSPTFSRAGS PLNNDMHENG LRYWHLVKHH DSDMQKEGER VNKLVSEIYL TRLLATKGTL1740
 1741 QKFVDDLFET IFSTAHRGSA LPLAIKYMFD FLDDQAQLHG ITDPEVVHTW KSNSLPLRFW1800
 1801 VNLIKNPNFV FDIHKSNIVD SCLSVVAQTF MDSCSTSDHR LGKDSPSSKL LYAKDIPEYR1860
 1861 KWVDRYYRDI RDMSPISDQD MNAMLAEESR LHTTEFNTNC ALHELYTYAV KYNEQLTVTL1920
 1921 EEDEFSQKQR LAFKLEQVHN IMSSE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..759] PSI-BLAST 79.045757 No description for 2uzxB was found.
    2 View Details [760..1014] PSI-BLAST 3.221849 Strucuture of the C-terminal domain of human thrombospondin-2
    3 View Details [1015..1189] Pfam 5.031517 No description for PF01833.15 was found. No confident structure predictions are available.
    4 View Details [1190..1273] FFAS03 0.987 Crystal structure of the TIG domain of human calmodulin-binding transcription activator 1 (CAMTA1)
    5 View Details [1274..1547] Pfam 16.568636 No description for PF08337.3 was found. No confident structure predictions are available.
    6 View Details [1548..1687] PSI-BLAST 39.0 No description for 2r2oA was found.
    7 View Details [1688..1945] FFAS03 1.49 GAP related domain of neurofibromin

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7
    Term Confidence Notes
  • GTPase regulator activity
    		•  4.62613920988983 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  4.60285041042816 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  4.29435235604933 bayes_pls_golite062009
  • GTPase activator activity
    		•  4.13669967154451 bayes_pls_golite062009
  • Ras GTPase activator activity
    		•  4.05218513298437 bayes_pls_golite062009
  • enzyme regulator activity
    		•  3.98479257898428 bayes_pls_golite062009
  • Rho GTPase activator activity
    		•  3.8483177561348 bayes_pls_golite062009
  • Rac GTPase activator activity
    		•  3.81745527802437 bayes_pls_golite062009
  • enzyme activator activity
    		•  3.68130398795056 bayes_pls_golite062009
  • ErbB-3 class receptor binding
    		•  2.28649100165615 bayes_pls_golite062009
  • protein binding
    		•  2.19203994051073 bayes_pls_golite062009
  • signal transducer activity
    		•  1.85770920700616 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.85770920700616 bayes_pls_golite062009
  • receptor activity
    		•  1.82582454265265 bayes_pls_golite062009
  • binding
    		•  1.60176934286866 bayes_pls_golite062009
  • Rho guanyl-nucleotide exchange factor activity
    		•  0.764662318607061 bayes_pls_golite062009
  • receptor binding
    		•  0.0304154938872172 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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