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View Structure Prediction Details

Protein: ubp12
Organism: Schizosaccharomyces pombe
Length: 979 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ubp12.

Description E-value Query
Range
Subject
Range
gi|114586840 - gi|114586840|ref|XP_001163407.1| PREDICTED: ubiquitin specific protease, proto-oncogene isoform 7 [P...
564.0 [0..43] [978..3]
gi|34932905, gi|... - ref|XP_214377.2| similar to Usp4 protein [Rattus norvegicus], gi|157824037|ref|NP_001099563.1| ubiqu...
563.0 [0..43] [978..3]
gi|15030172 - gi|15030172|gb|AAH11341.1| Usp4 protein [Mus musculus]
563.0 [0..43] [978..3]
gi|2656143, gi|1... - gi|40795667|ref|NP_955475.1| ubiquitin specific protease 4 isoform b [Homo sapiens], gi|2656143|gb|A...
562.0 [0..43] [978..3]

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Predicted Domain #1
Region A:
Residues: [1-157]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDSLSESSTS SYHGKRPRSL SEESQSSSNM DDISQKSISL GDASEISKNL PSIAEQKQLI  60
   61 GELVNNQPEL ELGQVDNYIL SYSWYERLCS YLAEDGPFPG PVDQEDIADL ETGTLKPDLQ 120
  121 EEIDFTIISR DVWDLLVRWY GLKGPEFPRE TVNLGSE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 28.39794
Match: 1w6vA
Description: Solution structure of the DUSP domain of hUSP15
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
small conjugating protein-specific protease activity 6.17519305564032 bayes_pls_golite062009
ubiquitin-specific protease activity 6.1483519675549 bayes_pls_golite062009
cysteine-type peptidase activity 5.52349554716375 bayes_pls_golite062009
binding 2.43973746940455 bayes_pls_golite062009
peptidase activity 2.16260367986128 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 1.99772512443601 bayes_pls_golite062009
protein binding 1.98124019646987 bayes_pls_golite062009
endopeptidase activity 1.65083162170561 bayes_pls_golite062009
cysteine-type endopeptidase activity 1.33423779714503 bayes_pls_golite062009
hydrolase activity 1.28832055307406 bayes_pls_golite062009
catalytic activity 0.639120026974844 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [158-284]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SHPHLVVEVY PPIFSLTLLS TNAVDANESH KPKKISLSSK STLEDLLEGV KYTLSLPSDQ  60
   61 FRLWRVDTDQ PLHRTIDPSS FIKINSKEII DFLEKSKTLV ELGMDSSCSL VAECMINETW 120
  121 PVDRALR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [285-630]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LQFLIQQRNN QSSNEEQKQE KRVPGTCGLS NLGNTCYMNS ALQCLTHTRE LRDFFTSDEW  60
   61 KNQVNESNPL GMGGQVASIF ASLIKSLYSP EHSSFAPRQF KATIGKFNHS FLGYGQQDSQ 120
  121 EFLAFLLDGL HEDLNRIYQK PYTSKPDLYE VDEEKIKNTA EECWRLHKLR NDSLIVDLFQ 180
  181 GMYRSTLVCP VCNTVSITFD PFMDLTLPLP VKQVWSHTVT FIPADTNLTP LAIEVVLESK 240
  241 AATIEDLVKY VAEKSGCSDY RKILVTETYK GRFYRFLTQL SKSLLMEISE EDEIYLYELE 300
  301 RPYEDGSDDI LVPVYHISDD STNSANSYMS SRDFGHPFVL QLSDNE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 61.221849
Match: 2gfoA
Description: No description for 2gfoA was found.

Predicted Domain #4
Region A:
Residues: [631-979]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VTDASFISEK LKLKYQQFTT LKNLKNIDSL ESLELGHEDE QVQKGPLDVD MDHSQTPLFE  60
   61 MRVFHDRFEK IPTGWNMSVS NLPLLTERDK KDLESTVDPL DAHSIEEEDD SEFKDVAPGS 120
  121 YPEPSKSNEN TKLTAKENDR LLIQGDLLVC EWPEKSYQFV FSVAPSSPQM GRSLWLESKT 180
  181 ILSDKKDDSE DSRTITLNDC LDEFEKTEQL GEEDPWYCPT CKEFRQASKQ MEIWRCPEIL 240
  241 IFHLKRFSSE RRFRDKIDDL VEFPIDNLDM SMRTGSYKLS EKENPKLIYE LYAVDNHYGG 300
  301 LGGGHYTAFA KNPDNGQFYC FDDSRVTPVC PEETVTSAAY LLFYRRKTS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 36.09691
Match: 1nb8A
Description: Ubiquitin carboxyl-terminal hydrolase 7 (USP7, HAUSP)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cysteine-type peptidase activity 6.54685807643041 bayes_pls_golite062009
small conjugating protein-specific protease activity 6.39247995905454 bayes_pls_golite062009
ubiquitin-specific protease activity 5.91394445088241 bayes_pls_golite062009
ubiquitin thiolesterase activity 4.1832081096766 bayes_pls_golite062009
peptidase activity 3.28868056127375 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 3.01472402774099 bayes_pls_golite062009
thiolester hydrolase activity 2.96735553959103 bayes_pls_golite062009
SUMO-specific protease activity 2.65263825059319 bayes_pls_golite062009
hydrolase activity 2.29464693834116 bayes_pls_golite062009
endopeptidase activity 2.26699762664334 bayes_pls_golite062009
cysteine-type endopeptidase activity 1.95802900199539 bayes_pls_golite062009
binding 1.3276268995308 bayes_pls_golite062009
catalytic activity 1.05972260874031 bayes_pls_golite062009
protein binding 1.01104209091599 bayes_pls_golite062009
NEDD8-specific protease activity 0.687958315289315 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.467924587720185 bayes_pls_golite062009
nucleic acid binding 0.439226369799415 bayes_pls_golite062009
calcium-dependent cysteine-type endopeptidase activity 0.196538841514154 bayes_pls_golite062009
DNA binding 0.168761518285256 bayes_pls_golite062009
transferase activity 0.0852393573521809 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle