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View Structure Prediction Details

Protein: die-1
Organism: Caenorhabditis elegans
Length: 645 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for die-1.

Description E-value Query
Range
Subject
Range
gi|76648475 - gi|76648475|ref|XP_881780.1| PREDICTED: similar to Zinc finger protein 197 (ZnF20) isoform 3 [Bos ta...
663.0 [0..17] [641..383]

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Predicted Domain #1
Region A:
Residues: [1-200]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MANAVDMQQL LMSMDPSSAN QFNMMNKGGA CVMATSGGSA SPTSSSGAPS SSSIMAETDE  60
   61 KDMFMPSQLI QNGLANNQLM SMILQQQSNQ ADSNIADAGH NNSGAEKNII ELLMSGNADL 120
  121 MKFATQFAQQ AKSVDQEPEE QRESSPSPPP AVSLNSTLAS MVFPTTSTAT ECSAASTTSS 180
  181 VDSAPSTVIV NGHSNSQSNT 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [201-344]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DDDDVTQQPS AKKQRTGDET PLTPTSNNQL MQSLLAQMGL SNPLHQQNQK QMKDESMMFS  60
   61 GLFPQGLAGI PLMFQSPLHQ QFAGMQDFEP LSALSTPNKG SGVKRQYSSN NKNFCDICNK 120
  121 EVCNKYFLRT HMLKMHGIVI DENK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.045757
Match: 1tf6A
Description: Transcription factor IIIA, TFIIIA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.5693324142242 bayes_pls_golite062009
transcription regulator activity 1.20084827450202 bayes_pls_golite062009
DNA binding 1.11228868978256 bayes_pls_golite062009
nucleic acid binding 1.10067326005752 bayes_pls_golite062009
transcription factor activity 0.33874886911135 bayes_pls_golite062009
protein binding 0.186544761618633 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [345-520]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TVIANIDTSI KEREGELTFR CDTCRTMFKT RNQLRQHRQD VHGVLPLSTP RNNPNKSSVP  60
   61 TTPNGANNNS GPNSASMSEE KCALCDKRVS PSMMMLHMAQ DHFGAAAANG DLNQMMAILG 120
  121 QRNQSTEEKM SSNLLECTDC SYKTRDPKNL DLHMERHIKM SEAKGRGDED EDVALQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 52.0
Match: 2i13A
Description: No description for 2i13A was found.

Predicted Domain #4
Region A:
Residues: [521-645]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTTEAALQMV VQNQNQYDGD STAAALNLTF KNDGTKKEIE EEKATGNHER NSHTSGSISP  60
   61 SGSIPEGFGK NIGEKAFPTQ SFLIKCNDDS GEFLTEFLAQ LPVRSVIDGP RQLVFNLHPA 120
  121 PPTTS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.221849
Match: 2gliA
Description: Five-finger GLI1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.5693324142242 bayes_pls_golite062009
transcription regulator activity 1.20084827450202 bayes_pls_golite062009
DNA binding 1.11228868978256 bayes_pls_golite062009
nucleic acid binding 1.10067326005752 bayes_pls_golite062009
transcription factor activity 0.33874886911135 bayes_pls_golite062009
protein binding 0.186544761618633 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle