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View Structure Prediction Details

Protein: skn-1
Organism: Caenorhabditis elegans
Length: 533 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for skn-1.

Description E-value Query
Range
Subject
Range
skn-1 - status:Confirmed UniProt:P34707 protein_id:AAA83594.2
314.0 [0..1] [533..91]

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Predicted Domain #1
Region A:
Residues: [1-93]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYTDSNNRNF DEVNHQHQQE QDFNGQSKYD YPQFNRPMGL RWRDDQRMME YFMSNGPVET  60
   61 VPVMPILTEH PPASPFGRGP STERPTTSSR YEY

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [94-248]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSPSLEDIDL IDVLWRSDIA GEKGTRQVAP ADQYECDLQT LTEKSTVAPL TAEENARYED  60
   61 LSKGFYNGFF ESFNNNQYQQ KHQQQQREQI KTPTLEHPTQ KAELEDDLFD EDLAQLFEDV 120
  121 SREEGQLNQL FDNKQQHPVI NNVSLSEGIV YNQAN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [249-449]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTEMQEMRDS CNQVSISTIP TTSTAQPETL FNVTDSQTVE QWLPTEVVPN DVFPTSNYAY  60
   61 IGMQNDSLQA VVSNGQIDYD HSYQSTGQTP LSPLIIGSSG RQQQTQTSPG SVTVTATATQ 120
  121 SLFDPYHSQR HSFSDCTTDS SSTCSRLSSE SPRYTSESST GTHESRFYGK LAPSSGSRYQ 180
  181 RSSSPRSSQS SIKIARVVPL A

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [450-533]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGQRKRGRQS KDEQLASDNE LPVSAFQISE MSLSELQQVL KNESLSEYQR QLIRKIRRRG  60
   61 KNKVAARTCR QRRTDRHDKM SHYI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.221849
Match: 1sknP
Description: Skn-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.56528092116191 bayes_pls_golite062009
DNA binding 4.39236205038451 bayes_pls_golite062009
nucleic acid binding 4.27517034548789 bayes_pls_golite062009
transcription factor activity 3.86034396858961 bayes_pls_golite062009
binding 3.28937567198027 bayes_pls_golite062009
protein binding 2.82801305666365 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.80824533696213 bayes_pls_golite062009
transcription activator activity 2.80670414213103 bayes_pls_golite062009
protein heterodimerization activity 1.87549895714075 bayes_pls_golite062009
protein dimerization activity 1.4553301455216 bayes_pls_golite062009
sequence-specific DNA binding 1.12585390480455 bayes_pls_golite062009
transcription factor binding 0.495155180229128 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle